Impaired expression of brain natriuretic peptide gene in diabetic rats with myocardial infarction

Abstract

Accordingly, we induced streptozotocin diabetes in rats and evaluated the effects of ligating the coronary artery to produce myocardial infarct by analyzing hemodynamics and the expression of brain natriuretic peptide (BNP) messenger (m) RNA. Eightweek diabetic rats and age-matched nondiabetic rats underwent ligation of the coronary artery for 1 week. Left ventricular enddiastolic pressure (LVEDP) was not statistically different between diabetic rats (15 ± 6 mmHg) and nondiabetic rats (13 ± 9 mmHg)