Impaired fibrinolytic capacity and early recurrent spontaneous abortion.

Abstract

The psychological consequences of diets that restrict energy intake are disputed. Our observations suggest that irritability and waking early in the morning were common in the third week of the diet. Whether these behavioural changes were related to decreased plasma concentrations of tryptophan could be investigated by supplementing the diet with tryptophan. There would be considerable interest if supplementation improved the compliance with, and effectiveness of, dieting. Unfortunately, pharmaceutical preparations of trvptophan have been withdrawn because of their suspected association with the eosinophilia-myalgia syndrome." It may be feasible, however, to investigate the effect of supplementation with tryptophan byrmanipulating the dietary intake of tryptophan and other amin acids. Trptophan remains important to the understanding of the relation between food intake and brain function. We thank Norma Brearley for preparing the manuscript.

Thrombin activatable fibrinolysis inhibitor and clot lysis time in women with recurrent miscarriage associated with the antiphospholipid syndrome

“…As noted by the investigators themselves, those studies were retrospective, the clinical characteristics of the patients were ill-defined, and systematic research for other causes of RM was not performed; thus, selection bias may have been introduced. Only two previous studies have investigated the overall fibrinolytic capacity of RM patients without aPL, and both reports concluded that impaired fibrinolysis could be a risk factor for thrombosis in future untreated pregnancies (21,22). This is in keeping with our study, in which longer CLT in the uRM group was found.…”

“…Genetic factors may explain between 20% and 62% of the variation in TAFI antigen levels, but the relationships among TAFI polymorphisms, TAFI antigen levels, and the risk of thrombotic complications are not well understood (21,22). We found no differences between groups in the distribution of alleles of the two investigated.…”

“…pathogenic mechanisms proposed (27,29). Previous work in recent literature has focused on fibrinolytic defects and RM (18)(19)(20)(21)(22)30). Remarkably, there are no eligible studies for TAFI, and data on other factors have either failed to show an association or were quite limited (30).…”

“…A few studies have investigated TAFI levels (18,19), TAFI polymorphisms (20), and overall fibrinolytic capacity (21,22) in patients with unexplained RM, but to the best of our knowledge there has been no previous report on TAFI or CLT in patients with aPL as the cause of their RM. This case-control study is a retrospective analysis of prospectively collected material to analyze the association between TAFI plasma antigen levels, TAFI polymorphisms, and CLT in APS patients with R3 RM (APS group).…”

Fibrinolytic Defects and Recurrent Miscarriage

“…1 It has been reported that many patients with recurrent miscarriage are in a prothrombotic stage even outside pregnancy, 2 and certain types of thrombophilias have been associated with increased risk for miscarriage. 3 The potential implication of fibrinolytic defects in recurrent miscarrige was first suggested in the early 1990s, 4 but research in this field has only recently become systematic.…”