Impaired Inter-Hemispheric Functional Connectivity during Resting State in Female Patients with Migraine

Zhang, Yanan; Liu, Geoffrey; Wang, Zhenjia; Liu, Junlian; Ren, Mengmeng; Hong, Yueying; Luo, Xuanzhi; Liu, Huilin; Huo, Jian-Wei; Wang, Zhenchang

doi:10.3390/brainsci12111505

“…Brain imaging studies on pain induction suggested that the primary somatosensory (S1), secondary somatosensory (S2), insula, prefrontal cortices and other brain regions could be regarded "pain matrix", whose functions were abnormal in the process of pain induction [37], which was consistent with our results. Dysfunctions of DMN and most regions of the sensorimotor circuit were involved in the neural mechanism of non-menstrual MwoA in female [38]. In this study, we found that DMN and sensorimotor circuit had a cross effect on the regulation and processing of pain, which could affect sensory, emotional and cognitive processing at multiple levels.…”

Section: Characteristics Of Changes Of Brain Spontaneous Activity And...mentioning

confidence: 56%

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Yang,

Wei,

Zhang

et al. 2024

BMC Complement Med Ther

1

0

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Objective To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI). Methods Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed. Results Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008). Conclusion Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA.

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“…Brain imaging studies on pain induction suggested that the primary somatosensory (S1), secondary somatosensory (S2), insula, prefrontal cortices and other brain regions could be regarded "pain matrix", whose functions were abnormal in the process of pain induction [21], which was consistent with our results. Dysfunctions of DMN and most regions of the sensorimotor circuit were involved in the neural mechanism of non-menstrual MwoA in female [22]. In this study, we found that DMN and sensorimotor circuit had a cross effect on the regulation and processing of pain, which could affect sensory, emotional and cognitive processing at multiple levels.…”

Section: Correlation Analysis Between Alff or DC Values And Sf-mpq Or...mentioning

confidence: 56%

Modulation of temporal and occipital cortex by acupuncture in non- menstrual MWoA patients: A Rest Bold fMRI study

Yang

¹

,

Wei

²

,

Zhang

³

et al. 2023

Preprint

0

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Objective To investigate the changes in amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC) values before and after acupuncture in young women with non-menstrual migraine without aura (MWoA) through rest blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI). Methods Patients with non-menstrual MWoA (Group 1, n = 50) and healthy controls (Group 2, n = 50) were recruited. fMRI was performed in Group 1 at 2 time points: before acupuncture (time point 1, TP1); and after the end of all acupuncture sessions (time point 2, TP2), and performed in Group 2 as a one-time scan. Patients in Group 1 were assessed with the Migraine Disability Assessment Questionnaire (MIDAS) and the Short-Form McGill Pain Questionnaire (SF-MPQ) at TP1 and TP2 after fMRI was performed. The ALFF and DC values were compared within Group 1 at two time points and between Group 1 and Group2. The correlation between ALFF and DC values with the statistical differences and the clinical scales scores were analyzed. Results Brain activities increased in the left fusiform gyrus and right angular gyrus, left middle occipital gyrus, and bilateral prefrontal cortex and decreased in left inferior parietal lobule in Group 1, which had different ALFF values compared with Group 2 at TP1. The bilateral fusiform gyrus, bilateral inferior temporal gyrus and right middle temporal gyrus increased and right angular gyrus, right superior marginal gyrus, right inferior parietal lobule, right middle occipital gyrus, right superior frontal gyrus, right middle frontal gyrus, right anterior central gyrus, and right supplementary motor area decreased in activity in Group 1 had different DC values compared with Group 2 at TP1. ALFF and DC values of right inferior temporal gyrus, right fusiform gyrus and right middle temporal gyrus were decreased in Group1 at TP1 compared with TP2. ALFF values in the left middle occipital area were positively correlated with the pain degree at TP1 in Group1 (correlation coefficient r, r = 0.827, r = 0.343; P < 0.01, P = 0.015). The DC values of the right inferior temporal area were positively correlated with the pain degree at TP1 in Group 1 (r = 0.371; P = 0.008). Conclusion Spontaneous brain activity and network changes in young women with non-menstrual MwoA were altered by acupuncture. The right temporal area may be an important target for acupuncture modulated brain function in young women with non-menstrual MwoA.

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“…We filtered one DC study (Ke et al, 2020) and two VMHC studies (Cao et al, 2022; Zhang et al, 2022). Combined with the existing included studies on ALFF, fALFF, and ReHo, we carried out AES‐SDM, ALE, and MKDA analysis again.…”

Section: Resultsmentioning

confidence: 99%

Regional abnormalities of spontaneous brain activity in migraine: A coordinate‐based meta‐analysis

Wen

¹

,

Gao

²

,

Li

³

et al. 2023

J of Neuroscience Research

3

0

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Many resting-state functional magnetic resonance imaging (rs-fMRI) studies have explored abnormal regional spontaneous brain activity in migraine. However, these results are inconsistent. To identify the consistent regions with abnormal neural activity, we meta-analyzed these studies. We gathered whole-brain rs-fMRI studies measuring differences in the amplitude of low-frequency fluctuations (ALFF), fractional ALFF (fALFF), or regional homogeneity (ReHo) methods. Then, we performed a voxel-wise meta-analysis to identify consistent abnormal neural activity in migraine by anisotropic effect size seed-based d mapping (AES-SDM). To confirm the AES-SDM meta-analysis results, we conducted two meta-analyses: activation likelihood estimation (ALE) and multi-level kernel density analysis (MKDA). We found that migraine showed increased regional neural activities in the bilateral postcentral gyrus (PoCG), left hippocampus (HIP.L), right pons, left superior frontal gyrus (SFG.L), triangular part of right inferior frontal gyrus (IFGtriang.R), right middle frontal gyrus (MFG.R), and left precentral gyrus (PreCG.L) and decreased regional intrinsic brain activities were exhibited in the right angular gyrus (ANG.R), left superior occipital gyrus (SOG.L), right lingual gyrus (LING.R). Moreover, the meta-analysis of ALE further validated the abnormal neural activities in the PoCG, right pons, ANG.R, and HIP. Meta-regression demonstrated that headache intensity was positively associated with the abnormal activities in the HIP.L, ANG.R, and LING.R. These findings suggest that migraine is associated with abnormal spontaneous brain activities of some pain-related regions, which may contribute to a deeper understanding of the neural mechanism of migraine.

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Impaired Inter-Hemispheric Functional Connectivity during Resting State in Female Patients with Migraine

Cited by 4 publications

References 50 publications

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Modulation of temporal and occipital cortex by acupuncture in non-menstrual MWoA patients: a rest BOLD fMRI study

Modulation of temporal and occipital cortex by acupuncture in non- menstrual MWoA patients: A Rest Bold fMRI study

Regional abnormalities of spontaneous brain activity in migraine: A coordinate‐based meta‐analysis

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