Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age

Massimo, C. Di; Scarpelli, Pietro; Lorenzo, Nicola Di; Caimi, Gregorio; Orio, Ferdinando di; Ciancarelli, Maria Giuliana Tozzi

doi:10.1016/j.lfs.2005.06.037

Cited by 60 publications

(37 citation statements)

References 31 publications

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“…Thus, it is suggested that antioxidant activity related to the bioavailability of NO is not impaired in the study participants. This result is in agreement with the study of Di Massimo et al 38 that showed NOx values regardless of the values of ecSOD.…”

Section: Figure 2 -Blood Flow (Panel a And B) And Vascular Resistancesupporting

confidence: 94%

“…Aerobic exercise can increase the activity of ecSOD and potentially increase the bioavailability of NO 11,20 . However, the biological activity of NO is dependent on superoxide anions, which compromise the functionality of NO 38 . In this study, the activity of ecSOD was lower for the TC + CC group compared to the TT group in the pre-training evaluation, but this difference did not reach statistical significance.…”

Section: Figure 2 -Blood Flow (Panel a And B) And Vascular Resistancementioning

confidence: 99%

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Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

Zago¹,

Kokubun²,

Fenty-Stewart³

et al. 2010

Arq. Bras. Cardiol.

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Section: Figure 2 -Blood Flow (Panel a And B) And Vascular Resistancesupporting

confidence: 94%

Section: Figure 2 -Blood Flow (Panel a And B) And Vascular Resistancementioning

confidence: 99%

Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

Zago¹,

Kokubun²,

Fenty-Stewart³

et al. 2010

Arq. Bras. Cardiol.

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“…133 EC-SOD activities were also diminished in healthy individuals with advancing age in whom decreased EC-SOD activity correlates with decreased plasma levels of nitrite/nitrate, suggesting that an impairment in antioxidant activity may reduce NO bioavailability. 134,135 Extracellular Catalase (Cat) Cat catalyzes the reduction of H2O2 generated by SOD to water and molecular oxygen: 2 H2O2 O2 + 2 H2O.…”

Section: Extracellular Antioxidant Enzymes Extracellular Superoxide Dmentioning

confidence: 99%

Redox Regulation in the Extracellular Environment

Ottaviano

Handy

Loscalzo

2008

Circ J

128

100

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Molecular oxygen is involved in the oxidation of substrates used to produce energy; however, normal metabolism can also generate harmful (bio)chemical byproducts. These deleterious products are partially reduced forms of oxygen, and include free radicals such as superoxide anion radical, hydroxyl radical, or highly oxidizing non-radical species such as hydrogen peroxide (H2O2) and lipid peroxides, which are collectively known as ROS. 1 ROS typically derive from normal metabolism, activated leukocytes, and ambient oxygen in the environment. The production and accumulation of ROS and their downstream effects can be controlled or attenuated by antioxidants. When the ability of antioxidants to eliminate harmful cellular and extracellular ROS is compromised, the balance between ROS generation and antioxidant function to eliminate ROS is shifted in favor of an accumulation of oxidants, which defines the state of oxidative stress in a cell or organism. Oxidative damage can affect DNA, lipids, and proteins, and eventually compromise cell integrity. Many studies have implicated ROS in the pathological processes leading to heart disease, cancer, aging, AIDS, and inflammatory and autoimmune diseases.Oxidants, especially free radicals, are highly reactive. Superoxide can react within milliseconds with nitric oxide (NO) to produce peroxynitrite (ONOO -), a reactive nitrogen species (RNS). The nitrosium cation and nitroxyl anion are other RNS derived from NO. 2 Peroxynitrite is a strong oxidant involved in the nitrosative modification of proteins and lipids. Owing to its rapid reaction with NO, superoxide may modulate NO bioavailability and, subsequently, regulate vascular function. 3 Circulation Journal Vol.72, January 2008The cytosol, mitochondria, peroxisomes, and plasma are all potential sites of ROS formation. 4 The major sources of ROS are enzymatic via nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox), xanthine oxidase, myeloperoxidase, endothelial NO synthase (eNOS), or as a consequence of normal mitochondrial respiration. In vascular cells, other enzymatic sources of ROS include cytochrome P450 isoenzymes, lipoxygenase, cyclooxygenase, heme oxygenase, and glucose oxidase. 1,3,[5][6][7] Most reviews to date have focused on the role of intracellular antioxidants that eliminate ROS from the intracellular environment. There are, however, several extracellular antioxidants that also play an equally important role in limiting ROS accumulation in the extracellular environment. Along with limiting ROS accumulation, extracellular redox status is essential for maintaining protein stability and function.The major enzymes important for the elimination of extracellular H2O2 are glutathione peroxidase-3 (GPx-3) and peroxiredoxin IV (Prx IV). Other extracellular antioxidants involved in ROS elimination include paraoxonase (PON), thioredoxin (Trx), Trx reductase (TrxR), glutaredoxin (Grx), extracellular superoxide dismutase (EC-SOD), and extracellular glutathione (GSH).Some of these antioxidants, notably glutathione...

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“…However, age was found to correlate positively with maximum serum creatinine values (rs=0.49, P=0.003). As NO levels are known to correlate inversely with age (Anstey et al, 1999, Di Massimo et al, 2006, Kleinbongard et al, 2006, Rath and Krantz, 1942, Toprakci et al, 2000, a partial correlation analysis was performed. After controlling for age, a significant correlation between NO levels and maximum serum creatinine value was observed (partial correlation coefficient=0.34, P=0.047, Fig.…”

mentioning

confidence: 99%

High serum nitric oxide levels in patients with severe leptospirosis

et al. 2006

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Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gramnegative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82 ± 10.90 μM versus 3.86 ± 1.34 μM, P<0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response.

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Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age

Cited by 60 publications

References 31 publications

Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

Efeito do exercício físico e do polimorfismo T-786C na pressão arterial e no fluxo sanguíneo de idosas

Redox Regulation in the Extracellular Environment

High serum nitric oxide levels in patients with severe leptospirosis

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