Impaired sleep and rhythms in persons with cancer

Lee, Kathryn; Cho, Maria; Miaskowski, Christine; Dodd, Marylin

doi:10.1016/j.smrv.2003.10.001

Cited by 165 publications

(134 citation statements)

References 69 publications

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“…Several recent reviews [3,6,[52][53][54][55][56] indicate that CRF and cancer-related sleep disorders are associated, and their prevalence and association depends on the timing of assessment (before diagnosis, before treatment, during treatment, and at various times after treatment). Following a review of the epidemiology of insomnia in patients with cancer, Savard and Morin [2] concluded that insomnia disorder added "an additional risk for experiencing intense and persistent fatigue after cancer treatment."…”

Section: Cancer-related Fatigue and Sleep Disordersmentioning

confidence: 99%

Cancer-Related Fatigue and Sleep Disorders

et al. 2007

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Sleep disorders, such as difficulty falling asleep, problems maintaining sleep, poor sleep efficiency, early awakening, and excessive daytime sleepiness, are prevalent in patients with cancer. Such problems can become chronic in some patients, persisting for many months or years after completion of cancer therapy. For patients with cancer, sleep is potentially affected by a variety of factors, including the biochemical changes associated with the process of neoplastic growth and anticancer treatments, and symptoms that frequently accompany cancer, such as pain, fatigue, and depression.Fatigue is highly prevalent and persistent in patients with cancer and cancer survivors. Although cancerrelated fatigue and cancer-related sleep disorders are distinct, a strong interrelationship exists between these symptoms, and a strong possibility exists that they may be reciprocally related. The majority of studies that have assessed both sleep and fatigue in patients with cancer provide evidence supporting a strong correlation between cancer-related fatigue and various sleep parameters, including poor sleep quality, disrupted initiation and maintenance of sleep, nighttime awakening, restless sleep, and excessive daytime sleepiness. This paper reviews the data from these studies with a view toward suggesting further research that could advance our scientific understanding both of potential interrelationships between sleep disturbance and cancer-related fatigue and of clinical interventions to help with both fatigue and sleep disturbance. The Oncologist 2007;12(suppl 1): [35][36][37][38][39][40][41][42]

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Section: Cancer-related Fatigue and Sleep Disordersmentioning

confidence: 99%

Cancer-Related Fatigue and Sleep Disorders

et al. 2007

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“…Fatigue is linked to disrupted sleep rhythms and the prevalence of fatigue rises to over 80% in patients undergoing chemotherapy (Lee et al, 2004). Indeed, approximately 50 -75% of cancer patients have fatigue levels that impair health-related quality of life (QoL) at diagnosis.…”

mentioning

confidence: 99%

“…It is uncertain whether cancer treatment affects circadian function (Lee et al, 2004). There is emerging evidence that suggests cancer patients are at high risk for problems associated with disrupted circadian function; poor sleep quality, fatigue, and decreased QoL.…”

mentioning

confidence: 99%

Circadian function in patients with advanced non-small-cell lung cancer

et al. 2005

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This study aimed to evaluate whether patients with advanced non-small-cell lung cancer experience disrupted rest -activity daily rhythms, poor sleep quality, weakness, and maintain attributes that are linked to circadian function such as fatigue. This report describes the rest -activity patterns of 33 non-small-cell lung cancer patients who participated in a randomised clinical trial evaluating the benefits of melatonin. Data are reported on circadian function, health-related quality of life (QoL), subjective sleep quality, and anxiety/depression levels prior to randomisation and treatment. Actigraphy data, an objective measure of circadian function, demonstrated that patients' rest -activity circadian function differs significantly from control subjects. Our patients reported poor sleep quality and high levels of fatigue. Ferrans and Powers QoL Index instrument found a high level of dissatisfaction with healthrelated QoL. Data from the European Organization for Research and Treatment for Cancer reported poor capacity to fulfil the activities of daily living. Patients studied in the hospital during or near chemotherapy had significantly more abnormal circadian function than those studied in the ambulatory setting. Our data indicate that measurement of circadian sleep/activity dynamics should be accomplished in the outpatient/home setting for a minimum of 4 -7 circadian cycles to assure that they are most representative of the patients' true condition. We conclude that the daily sleep/activity patterns of patients with advanced lung cancer are disturbed. These are accompanied by marked disruption of QoL and function. These data argue for investigating how much of this poor functioning and QoL are actually caused by this circadian disruption, and, whether behavioural, light-based, and or pharmacologic strategies to correct the circadian/sleep activity patterns can improve function and QoL.

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“…15 Other studies say the rate may actually be much higher 75 percent of all cancer patients reporting long and short term insomnia. Similarly, in the study done by Portenoy et al (1994), found the prevalence rates of insomnia varying from 48.6% to 60%.…”

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confidence: 97%

Prevalence of sleep – wake cycle disturbance among cancer patients of Bhaktapur cancer hospital, Nepal

Marita

Pandey

2017

J Chitwan Med Coll

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Cancer patients are at great risk for developing insomnia and disorders of the sleep-wake cycle. Insomnia is the most common sleep disturbance in this population and is most often secondary to physical and/or psychological factors related to cancer and/or cancer treatment. It is estimated that nearly 45% of cancer patients experience sleep disturbances; this is nearly three times the estimate of its occurrence in the general population. The purpose of the study is to determine the prevalence of sleep-wake cycle disturbance in patient receiving chemotherapy. A descriptive cross-sectional study was carried out in 2013. A total of 205 respondents, visiting Bhaktapur Cancer Hospital and who met criteria were purposively sampled and interviewed face to face. Insomnia Severity Index Scale was used to grade insomnia. Descriptive statistics such as frequency and percentage was used to describe demographic data. Chi-square test was done to find out the association between prevalence of sleep-wake cycle disturbance and selected variables. Among the total respondents (205), 70.7% had sleep-wake cycle disturbances. Majority (71.21%) of respondents had some form of clinically significant insomnia. The ages of the respondents ranged from 20 to 81 years with the mean age of 56.25 (SD ± 13.87). More than half i.e. 69.3% of the respondents were female. Patients being treated with Methotrexate were found to be more associated with the development of sleep-wake cycle disturbance. The significant association was found on drinking tea/coffee with the prevalence sleep-wake cycle disturbance. Sleep disorders are a common and often chronic problem for patients with cancer. Recently, such symptoms have attracted little attention. This might be the reasons for increased prevalence of sleep-wake cycle disturbance. It is recommended to take early and adequate intervention for the reduction of increased prevalence rate of sleep-wake cycle disturbance.

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Impaired sleep and rhythms in persons with cancer

Cited by 165 publications

References 69 publications

Cancer-Related Fatigue and Sleep Disorders

Cancer-Related Fatigue and Sleep Disorders

Circadian function in patients with advanced non-small-cell lung cancer

Prevalence of sleep – wake cycle disturbance among cancer patients of Bhaktapur cancer hospital, Nepal

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