Impaired systemic vascular reactivity &amp; raised high-sensitivity C reactive protein levels in chronic obstructive pulmonary disease

Khare, Parul; Talwar, Anjana; Chandran, Dinu S; Guleria, Randeep; Jaryal, Ashok Kumar; Kumar, Guresh; Trivedi, Anjali; Deepak, Kishore Kumar

doi:10.4103/0971-5916.180209

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Baroreceptor sensitivity must be controlled in Insulinresistant patients to reduce the chances of morbidity of cardiovascular conditions. 32 IR is the major driver of cardiovascular diseases in obese and non-obese groups which refers to the fact that diabetic patients have higher chances of being affected by cardiovascular disease. Preobese period and post-obese period both include the risks of cardiovascular conditions among diabetes patients if the Insulin level is not within the desired level.…”

Section: Discussionmentioning

confidence: 99%

Effect of highly sensitive C-reactive protein on cardiovascular risk of Type 2 diabetes mellitus adults: A systematic review

Upreti,

Mingma Lhamu Sherpa,

Karma Lakhi Bhutia

2024

Asian J Med Sci

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Diabetes mellitus (DM) is a significant global health issue that affects nearly 537 million of people, with Type 2 DM (T2DM) accounting for the majority of cases. Death is frequently the result of diabetes-related complications, particularly cardiovascular illnesses, neuropathy, retinopathy, and nephropathy. Type 2 diabetes and cardiovascular events, such as coronary heart disease (CHD), are linked to a greater likelihood of creating when C-reactive protein (CRP), a representative acute phase inflammation response protein, is elevated. The purpose of this systematic review is to examine how T2DM adults’ cardiovascular risk is affected by highly sensitive CRP (hsCRP). The information found through searches of digital sources such as EBSCO, EMBASE, PubMed, Scopus, and Web of Science. The investigator separately reviewed each abstract and title in comparison to predetermined inclusion and exclusion standards. Google Scholar was used for further research. Using terms, a thorough search plan was created. The terms “hs-CRP,” “Type 2 diabetes mellitus,” and “cardiovascular disease” have been utilized. To translate the results for other databases, the original search was done in PubMed. To find additional pertinent papers, reference lists of the research included and previously released reviews were also examined. The findings state that people with DM have a higher risk of developing heart disease. Due to their elevated carbohydrate intake, unhealthy diet, and genetic disposition, Asian Indians are at a high risk of developing cardiovascular disease and DM. Diabetes patients’ cardiovascular risk is primarily determined by insulin sensitivity, which can be assessed using the markers hsCRP and tumor necrosis factor-. Lipid profile is important in cardiovascular diseases because high blood glucose levels encourage the body’s production of cholesterol, which increases the risk of heart malfunction in obese diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Effect of highly sensitive C-reactive protein on cardiovascular risk of Type 2 diabetes mellitus adults: A systematic review

Upreti,

Mingma Lhamu Sherpa,

Karma Lakhi Bhutia

2024

Asian J Med Sci

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Exploring the repeatability of pulse arrival time in healthy subjects: A test-retest approach

Jose,

Srivastav,

Mehta

2024

IJPP

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Objectives: Vascular ageing is increasingly being recognised as a vital marker of cardiovascular morbidity and mortality. Assessment of vascular stiffness is an important parameter in this context. Pulse arrival time (PAT) assessed using photoplethysmography (PPG) and digital electrocardiogram (ECG) signals is a feasible and cost-effective parameter for this assessment. However, there are few, if any, studies that have assessed the test-retest repeatability of this parameter over time. Materials and Methods: We computed PAT using finger PPG and Lead II ECG and measured it sequentially at five instances over a period of 1 month in 21 healthy adults (10 males and 11 females). Mean and diastolic blood pressure (MBP and DBP) and heart rate (HR) were also measured at each visit. A novel parameter, PAT normalised for HR of 75 (PAT-75), was also computed. PAT and PAT-75 were compared for these visits using repeated measures analysis of variance. The intraclass correlation coefficient (ICC) was used to assess the test-retest reliability of this parameter. Results: MBP, DBP, and PAT values did not show any difference between the visits. HR was significantly different between the visits. PAT-75 was significantly lower for the afternoon of day 1 as compared to the forenoon. ICC demonstrated only moderate reliability of PAT (ICC = 0.57), with further reduction observed for PAT-75 (ICC = 0.38). Conclusion: PAT was only moderately repeatable on repeated evaluation over a 1-month period. This finding may have implications for the large-scale applicability of this technology, and therefore, we propose further investigation into the repeatability of this parameter in large cohorts.

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Impaired systemic vascular reactivity & raised high-sensitivity C reactive protein levels in chronic obstructive pulmonary disease

Cited by 2 publications

References 31 publications

Effect of highly sensitive C-reactive protein on cardiovascular risk of Type 2 diabetes mellitus adults: A systematic review

Effect of highly sensitive C-reactive protein on cardiovascular risk of Type 2 diabetes mellitus adults: A systematic review

Exploring the repeatability of pulse arrival time in healthy subjects: A test-retest approach

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