Impairment of Endothelial Function in Unipolar and Bipolar Depression

Rybakowski, Janusz; Wykretowicz, Andrzej; Heymann-Szlachcinska, Agnieszka Maria; Wysocki, Henryk

doi:10.1016/j.biopsych.2006.03.025

Cited by 93 publications

(61 citation statements)

References 11 publications

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“…3). There are several studies on vascular changes in depression, for example, ischemic lesions located in the dorsolateral prefrontal cortex were observed in depressed subjects [24], and endothelial changes in MDD patients [25]. eNOS regulates blood vessel constriction and blood pressure [26].…”

Section: Discussionmentioning

confidence: 98%

Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.

Yoshino

Ochi

Yamazaki

et al. 2015

Neuroscience Letters

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Section: Discussionmentioning

confidence: 98%

Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.

Yoshino

Ochi

Yamazaki

et al. 2015

Neuroscience Letters

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“…Studies investigating the association between depression and arteriosclerosis have used a variety of indexes for vascular function (Lavoie et al 2010;Oulis et al 2010;Paranthaman et al 2010;Rajagopalan et al 2001;Rybakowski et al 2006;Sherwood et al 2005;Tiemeier et al 2003). Irrespective of these different outcome measures, all studies unanimously have shown depressed individuals to have impaired endothelial function or increased arterial stiffness.…”

Section: Existing Evidence On Association Between Depression and Subcmentioning

confidence: 99%

Depression, Vascular Conditions and Chronicity

Seldenrijk¹,

Vogelzangs²,

Oppen³

et al. 2013

Psychiatric Disorders - New Frontiers in Affective Disorders

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“…Correspondingly, a number of epidemiological studies have shown a higher prevalence of cardiovascular risk and cardiovascular mortality in patients with mood disorders [8]. In our previous study we have demonstrated that patients with both unipolar and bipolar depression presented with endothelial dysfunction [9]. However, a relationship between HCY and cardiovascular status in patients with mood disorders has not been studied so far.…”

Section: Introductionmentioning

confidence: 98%

Hyperhomocysteinemia in Bipolar Depression: Clinical and Biochemical Correlates

Permoda-Osip

Dorszewska²,

Skibińska

et al. 2013

Neuropsychobiology

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Background: Depression may be associated with elevated homocysteine (HCY) levels. Procedures aiming at its decrease, i.e. supplementation with folic acid or vitamin B₁₂, have antidepressant effect. Both depression and elevated HCY can increase cardiovascular risk. In this study, clinical and biochemical factors, including markers of endothelial function, in relation to hyperhomocysteinemia, in patients with bipolar depression during acute episode were studied. Method: One hundred and twelve patients (24 male, 88 female), aged 20-78 (mean 51 ± 14 years), with depressive episode in the course of bipolar mood disorder have been included. The assays were made of serum concentrations of HCY, vitamin B₁₂, folic acid as well as markers of endothelial function such as E-selectin and intracellular adhesion molecule-1 (ICAM-1). Results: Hyperhomocysteinemia (>15 mM)was found in 50 patients (45%), significantly more frequently in male (67%) than in female subjects (39%). Female patients with hyperhomocysteinemia were significantly older than the remaining ones. A significant inverse correlation between HCY level and concentration of folic acid and vitamin B₁₂ as well as with E-selectin and ICAM-1 was observed. Conclusion: The results point to a significant prevalence of hyperhomocysteinemia in bipolar depressed patients during an acute episode. They also corroborate the correlation between increased concentration of HCY and lower level of vitamin B₁₂ and folic acid. An unexpected finding of negative correlation of HCY level with markers of endothelial functions in such patients is discussed in view of current concepts of the role of HCY in various conditions.

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Impairment of Endothelial Function in Unipolar and Bipolar Depression

Cited by 93 publications

References 11 publications

Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.

Antidepressant action via the nitric oxide system: A pilot study in an acute depressive model induced by arginin.

Depression, Vascular Conditions and Chronicity

Hyperhomocysteinemia in Bipolar Depression: Clinical and Biochemical Correlates

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