Impairment of Neutrophil Bactericidal Capacity in Patients with AIDS

Pm, Murphy; Hc, Lane; As, Fauci; Ji, Gallin

doi:10.1093/infdis/158.3.627

Cited by 152 publications

(56 citation statements)

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“…Murphy el a/. (14) found SO production by PMA-stimulated PMN from adults with HIV to be higher compared with PMN from normal adults, but the assay ran for only 10 min. Our assays were read over a 2-h period and the differences between normal and HIV PMN were greatest at 2 h. Roilides et al (5) reported a similar study that found SO generation by PMN from HIV-infected children the same as that of age-matched controls, but the incubation period was only 5 min.…”

Section: Discussionmentioning

confidence: 99%

Decreased Superoxide Anion and Hydrogen Peroxide Production by Neutrophils and Monocytes in Human Immunodeficiency Virus-Infected Children and Adults

Chen

Roberts

et al. 1993

Pediatr Res

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Section: Discussionmentioning

confidence: 99%

Decreased Superoxide Anion and Hydrogen Peroxide Production by Neutrophils and Monocytes in Human Immunodeficiency Virus-Infected Children and Adults

Chen

Roberts

et al. 1993

Pediatr Res

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“…It is not clear, however, that infection depends exclusively on Fc receptormediated uptake of virus-antibody complexes by these cells (47,48). Exposure to circulating immune complexes may also suppress neutrophil bactericidal activity in AIDS patients (49) and, by saturating the available Fc receptors of fixed tissue phagocytes, may significantly reduce intravascular clearance of opsonized particulates (13,50).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, transendothelial migration, and cell surface phenotype.

Trial

Birdsall²,

Hallum³

et al. 1995

J. Clin. Invest.

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We postulated that changes in the cell surface display of molecules that facilitate cell-cell and cell-matrix adhesions may reflect the changing immunosurveillance capacity of blood monocytes during progression of human immunodeficiency virus (HIV) infections. In Centers for Disease Control (CDC) stage A patients, whose monocytes' ability to phagocytose bacteria and generate reactive oxygen intermediates is often increased, the frequency of monocytes expressing CD49d, HLA-DP, HLA-DQ, and an activation epitope of CD11a/CD18 was increased and monocyte transendothelial migration was unimpaired. In CDC stage B/C patients, whose monocytes' ability to phagocytose bacteria and migrate across confluent endothelial monolayers was diminished, surface expression of CD49e and CD62L and the percentage of monocytes expressing CD18, CD11a, CD29, CD49e, CD54, CD58, CD31, and HLA-I were significantly decreased. Incubating normal donor monocytes with immune complexes in vitro reproduced the phenotypic and functional abnormalities seen in stage B/C patients. By contrast, in vitro stimulation with subcellular particulates released by apoptotic lymphocytes reproduced changes seen in stage A patients' monocytes. Although circulating monocytes appear to be activated at all stages, these data suggest that the high levels of circulating immune complexes, found predominantly in the later stages of HIV infection, may be particularly instrumental in reducing the monocyte's capacity to maintain surveillance against infection. (J. Clin. Invest. 1995. 95:1690-1701

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“…sin embargo, un número significativo de pacientes con sIDa desarrollan neutropenia como consecuencia de la infección retroviral directa, el uso de medicamentos antirretrovirales, infecciones sistémicas y los mecanismos autoinmunes alterados 26 . además, los neutrófilos de pacientes con SIDA tienen su función bactericida y quimiotáctica deficiente 27,28 . en consecuencia, se ha propuesto que el deterioro de la función de los neutrófilos, junto con defecto en la síntesis de inmunoglobulinas son causas importantes en el aumento del riesgo de infecciones bacterianas en pacientes con enfermedad avanzada por VIH…”

Section: Compromiso De La Vía Aéreaunclassified

Principios para el tratamiento de infecciones odontogénicas con distintos niveles de complejidad

2012

Rev Chil Cir

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Principles for the treatment of odontogenic infections with different levels of complexity odontogenic infections are one of the main causes of consultation in dental practice. these, affect individuals of all ages and are responsible for the majority of antibiotic prescriptions in the field of dentistry. odontogenic infections are generally underestimated in terms of morbidity and mortality, although the incidence and severity have decreased dramatically over the past 70 years. However, odontogenic infections can have varying degrees of severity and even some can be quite complex and need emergency care in a hospital setting under a specialist in oral and Maxillofacial surgery. odontogenic infections are commonly the result of pericoronitis, caries with pulp exposure, periodontitis or complication of a dental procedure. the literature contains various principles and approaches for odontogenic infections therefore the objective of our review is to establish a simplified manner based on the current literature, the principles that the clinician should follow to face odontogenic infections with different levels of complexity.Key words: odontogenic infection, odontogenic abscess, antibiotics.Resumen las infecciones odontogénicas son una de las principales causas de consulta en la práctica odontológi-ca. estas afectan a individuos de todas las edades y son responsables de la mayoría de las prescripciones de antibióticos en el campo de la odontología. las infecciones odontogénicas son generalmente subestimadas en términos de morbilidad y mortalidad, aunque su incidencia y severidad han bajado drásticamente en los últi-mos 70 años. sin embargo, estas infecciones pueden presentar distintos grados de severidad e incluso algunas pueden ser bastante complejas y necesitar una atención de emergencia en un ambiente hospitalario bajo un especialista en cirugía Bucal y Maxilofacial. las infecciones odontogénicas son comúnmente el resultado de una pericoronaritis, caries con exposición pulpar, periodontitis o la complicación de un procedimiento dental. . estas Ios pueden presentar distintos grados de severidad e incluso algunas pueden ser bastante complejas y necesitar atención de emergencia en un ambiente hospitalario bajo un especialista en cirugía Bucal y Maxilofacial.las Ios son generalmente subestimadas en térmi-nos de morbilidad y mortalidad, si bien la incidencia y severidad han bajado drásticamente en los últimos 70 años. Históricamente, la posibilidad de que un absceso de origen dental se propagara generando sepsis y la muerte ha sido conocido desde la antigüe-dad, aunque el rol de las bacterias en este proceso no fue descubierto hasta el siglo XX. cuando los certificados de defunción (Londres, Inglaterra) comenzaron a mostrar las causas de muerte a comienzos del 1600´s, las infecciones de origen dental ocupaban el sexto lugar 2 . en 1940, ahsbel Williams publicó una serie de 31 casos de angina de ludwig, la gran mayoría de origen dental, donde el 54% de los pacientes fallecieron 3 . tres años más tarde guralnic...

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Impairment of Neutrophil Bactericidal Capacity in Patients with AIDS

Cited by 152 publications

References 0 publications

Decreased Superoxide Anion and Hydrogen Peroxide Production by Neutrophils and Monocytes in Human Immunodeficiency Virus-Infected Children and Adults

Decreased Superoxide Anion and Hydrogen Peroxide Production by Neutrophils and Monocytes in Human Immunodeficiency Virus-Infected Children and Adults

Principios para el tratamiento de infecciones odontogénicas con distintos niveles de complejidad

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