Impairment of rapid repetitive finger movements and visual reaction time in patients with essential tremor

Jiménez‐Jiménez, Félix Javier; Rubio, Lluisa; Alonso‐Navarro, Hortensia; Calleja, Marisol; Pilo‐de‐la‐Fuente, Belén; Plaza-Nieto, José Francisco; Benito‐León, Julián; García‐Ruiz, Pedro J.; Agúndez, José A. G.

doi:10.1111/j.1468-1331.2009.02784.x

Cited by 62 publications

(58 citation statements)

References 28 publications

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“…PS speed in our healthy subjects was correlated with that for FT in the right (dominant), but not in the left hand. Despite this correlation, patients with Parkinson's disease [54] or essential tremor [55] have shown a worse performance for the FT tasks than for PS.…”

Section: Discussionmentioning

confidence: 94%

Influence of age and gender in motor performance in healthy subjects

Jiménez‐Jiménez

Calleja

Alonso‐Navarro

et al. 2011

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 94%

Influence of age and gender in motor performance in healthy subjects

Jiménez‐Jiménez

Calleja

Alonso‐Navarro

et al. 2011

Journal of the Neurological Sciences

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“…2–4 The weight of emerging evidence is indicating that, aside from motor manifestations, ET is also associated with a number of nonmotor manifestations, including cognitive deficits, 5 dementia, 6 depressive symptoms, 7 changes in sleep patterns, 8 changes in visual reaction time, 9 and hearing impairment. 10,11 Clinical and imaging studies point to cerebellar involvement, and the tremor is thought to be mediated by a neuronal loop involving cerebello-thalamo-cortical pathways.…”

Section: Introductionmentioning

confidence: 99%

Altered Functional Connectivity in Essential Tremor

et al. 2015

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Essential tremor (ET) has been associated with a spectrum of clinical features, with both motor and nonmotor elements, including cognitive deficits. We employed resting-state functional magnetic resonance imaging (fMRI) to assess whether brain networks that might be involved in the pathogenesis of nonmotor manifestations associated with ET are altered, and the relationship between abnormal connectivity and ET severity and neuropsychological function.Resting-state fMRI data in 23 ET patients (12 women and 11 men) and 22 healthy controls (HC) (12 women and 10 men) were analyzed using independent component analysis, in combination with a “dual-regression” technique, to identify the group differences of resting-state networks (RSNs) (default mode network [DMN] and executive, frontoparietal, sensorimotor, cerebellar, auditory/language, and visual networks). All participants underwent a neuropsychological and neuroimaging session, where resting-state data were collected.Relative to HC, ET patients showed increased connectivity in RSNs involved in cognitive processes (DMN and frontoparietal networks) and decreased connectivity in the cerebellum and visual networks. Changes in network integrity were associated not only with ET severity (DMN) and ET duration (DMN and left frontoparietal network), but also with cognitive ability. Moreover, in at least 3 networks (DMN and frontoparietal networks), increased connectivity was associated with worse performance on different cognitive domains (attention, executive function, visuospatial ability, verbal memory, visual memory, and language) and depressive symptoms. Further, in the visual network, decreased connectivity was associated with worse performance on visuospatial ability.ET was associated with abnormal brain connectivity in major RSNs that might be involved in both motor and nonmotor symptoms. Our findings underscore the importance of examining RSNs in this population as a biomarker of disease.

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“…Support for this suggestion that the execution of rhythmic behavior is unaffected by ET has been provided by Ozekmekci et al (2005), who found that individuals with ET and controls did not perform differently a sequential-tapping task. Whereas the previous research suggested that initiation is largely unaffected in ET, other studies did show that both movement initiation and execution were affected (Montgomery, Baker, Lyons, & Koller, 2000;Jimenez-Jimenez et al, 2010). For example, Montgomery and colleagues showed that the reaction time and movement velocity of a wrist flexion and extension task were slower for individuals with ET and PD.…”

mentioning

confidence: 86%

“…For example, Montgomery and colleagues showed that the reaction time and movement velocity of a wrist flexion and extension task were slower for individuals with ET and PD. Also, JimenezJimenez and colleagues showed that individuals with ET exhibited impairments in rapid repetitive finger movements and visual reaction time tasks (Jimenez-Jimenez et al, 2010), whereas Farkas, Szirmai, and Kamondi (2006) showed higher variability in individuals with ET than in controls when they rhythmically tapped their fingers and made alternating hand movements (Farkas et al, 2006). In general, it can be concluded that individuals with ET have a measurable disability with time-based upper-extremity function (Heroux, Parisi, Larocerie-Salgado, & Norman, 2006).…”

mentioning

confidence: 99%

Characterization of graphomotor functions in individuals with Parkinson’s disease and essential tremor

Gemmert

Chang

2016

Behav Res

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In this study, we explored the relationship between the clinical features and motor impairments related to the graphomotor function of individuals with Parkinson's disease (PD) and essential tremor (ET). We recruited 46 participants: 12 with PD, 13 with ET, and 21 controls. All participants were asked to perform six graphomotor tasks on a digitizer tablet: drawing straight lines, cursive-connected loops, discrete circles, and continuous circles, and making goal-aimed movements with a stylus in two different directions with three different accuracy constraints. The results showed that although participants with PD were able to draw straight lines slightly faster than controls, they produced cursive-connected loops much slower than controls. In addition, in contrast to controls and individuals with ET, PDs also drew the cursive loops progressively smaller. In the aiming task, we found that equivalent movements with high accuracy constraints were drawn slower by individuals with ET or PD than by controls. However, when performing the equivalent movements with moderate or low accuracy constraints, PDs performed similarly to controls. In contrast to the equivalent movements, PD and ET participants both performed nonequivalent movements slower than controls, no matter the demands arising from the accuracy constraints. The present study shows that simple graphic tasks can differentiate impairments in fine motor function resulting from ET and PD.

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Impairment of rapid repetitive finger movements and visual reaction time in patients with essential tremor

Cited by 62 publications

References 28 publications

Influence of age and gender in motor performance in healthy subjects

Influence of age and gender in motor performance in healthy subjects

Altered Functional Connectivity in Essential Tremor

Characterization of graphomotor functions in individuals with Parkinson’s disease and essential tremor

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