Impedance pH Guided Approach to Proton Pump Inhibitor-refractory Non-erosive Reflux Disease

Cho, Yu Kyung

doi:10.5056/jnm.20.419.

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…11 Though PPIs are highly effective in neutralizing gastric acid and preventing esophageal acidification, non-acidic liquid reflux remains to be a significant problem in a large proportion of patients. 10,26 The association between degree of gastric acid suppression and occurrence of non-acidic reflux has not been studied adequately. We found that patients without NAB, who had greater degree of gastric acid suppression, had more frequent abnormal 24-hour esophageal bolus exposure and positive symptom index for non-acid reflux than patients with NAB.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi

Ghoshal

Singh

et al. 2017

J Neurogastroenterol Motil

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Background/AimsThough nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting proton pump inhibitor, may cause NAB infrequently. Accordingly, we studied prospectively, (1) frequency and degree of esophageal acidification during NAB, and (2) frequency and severity of NAB while on ilaprazole versus omeprazole. MethodsFifty-eight consecutive patients with GERD on once daily ilaprazole, 10 mg (n = 28) or omeprazole, 20 mg (n = 30) for > one month underwent 24-hour impedance-pH monitoring prospectively. NAB was defined as intra-gastric pH < 4 for > one hour during night, and esophageal acidification as pH < 4 for any duration. Nocturnal symptoms (heartburn, regurgitation, and chest pain) were also recorded. Results Of ConclusionsThough NAB was common while patients were on a proton pump inhibitor, esophageal acidification was uncommon. Frequency and severity of NAB were comparable among patients on ilaprazole and omeprazole, except for the lesser number of NABs with ilaprazole.

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Section: Discussionmentioning

confidence: 99%