Impfung bei Immunsuppression

Laws, Hans‐Jürgen

doi:10.1007/s00112-013-2884-9

Monatsschr Kinderheilkd

2013

DOI: 10.1007/s00112-013-2884-9

|View full text |Cite

Impfung bei Immunsuppression

Hans‐Jürgen Laws

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,4 Complications including pain crises, aplastic crises, asplenia, and ischemic stroke have been described in case reports. 5,6 Because of the rarity of the disease and lack of a longitudinal sickle cell disease (SCD) database, most of our knowledge of HbSD-Los Angeles disease is limited to case reports and management guidelines are extrapolated from that of homozygous SCD.…”

mentioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 Infection Presenting as Acute Chest Syndrome in a Child With Hemoglobin SD-Los Angeles Disease: A Case Report and Review of Literature

Calderwood

Sabir

Rao

et al. 2022

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

Hemoglobin D-Los Angeles is a variant of hemoglobin that can polymerize in the deoxygenated state. When co-inherited with Hemoglobin S (HbSD-Los Angeles disease) a severe sickling syndrome similar to HbSS can result. Corona virus infectious disease 2019 (COVID-19) is caused by the severe acute respiratory syndromecorona virus-2. It has been associated with acute chest syndrome (ACS) in individuals with sickle cell disease (SCD), but this complication has not previously been reported in patients with HbSD-Los Angeles. Dexamethasone has been shown to improve outcomes in non-SCD patients with severe acute respiratory syndrome-corona virus-2 pneumonia or acute respiratory distress syndrome; however, its use in SCD patients with ACS is controversial due to a reported increased risk of complications including vaso-occlusive painful episodes. Herein, we reported a patient with HbSD-Los Angeles and COVID-19-associated ACS whom we treated with dexamethasone without transfusion. The patient experienced a rapid recovery without sequelae from steroid use.To further evaluate the use of steroids, we conducted a literature review focusing on the management of pediatric SCD patients with COVID-19-associated ACS. We identified a total of 39 pediatric patients with SCD and COVID-19, of whom 21 (54%) had ACS. Packed red blood cell transfusion (n = 11), exchange transfusion (n = 4), or a combination of exchange transfusion and packed red blood cell transfusion (n = 4) were the most frequently reported treatment, with hydroxychloroquine (n = 5), remdesivir (n = 1), and tocilizumab (n = 1) also being reported. Three patients were treated with dexamethasone. All patients recovered and no adverse outcomes from steroid use were reported. Even though transfusion is considered the standard of care for children with ACS and steroids are not routinely recommended, our experience suggested that COVID-19-associated ACS may be an important exception, especially for patients who refuse transfusion or are in resourcepoor nations where blood transfusions may not be readily available. Further studies are warranted to confirm these observations.

show abstract

mentioning

confidence: 99%

“…Clinical manifestations are described to be similar to homozygous SS disease; although, persistent splenomegaly is observed more commonly in HbSD than HbSS 3,4. Complications including pain crises, aplastic crises, asplenia, and ischemic stroke have been described in case reports 5,6…”

mentioning

confidence: 99%

SARS-CoV-2 Infection Presenting as Acute Chest Syndrome in a Child With Hemoglobin SD-Los Angeles Disease: A Case Report and Review of Literature

Calderwood

Sabir

Rao

et al. 2022

Journal of Pediatric Hematology/Oncology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Impfung bei Immunsuppression

Cited by 1 publication

References 40 publications

SARS-CoV-2 Infection Presenting as Acute Chest Syndrome in a Child With Hemoglobin SD-Los Angeles Disease: A Case Report and Review of Literature

SARS-CoV-2 Infection Presenting as Acute Chest Syndrome in a Child With Hemoglobin SD-Los Angeles Disease: A Case Report and Review of Literature

Contact Info

Product

Resources

About