Implanon® : difficultés d'insertion et de retrait, échecs contraceptifs

Bensouda-Grimaldi, L.; Jonville-Béra, A.-P.; Beau-Salinas, F.; Llabrés, Soledad Cañellas; Autret-Leca, É.; pharmacovigilance, le réseau des centres régionaux de

doi:10.1016/j.gyobfe.2005.10.016

Cited by 36 publications

(10 citation statements)

References 15 publications

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“…3 A variety of potent enzyme inducers known to have deleterious effects on hormonal contraceptives include some antiepileptics (carbamazepine, oxcarbazepine, phenytoin, phenobarbital, primidone, topiramate), [16][17][18][19] antibiotics (rifampicin, rifabutin), [20][21][22][23][24] antifungals (griseofulvin), 25 protease inhibitors (amprenavir, atazanavir, nelfinavir, lopinavir, saquinavir, ritonavir), 26 and non-nucleoside reverse transcriptase inhibitors (efavirenz, nevirapine). 27 There have been sporadic reports of Implanon failure due to suspected interaction with concomitantly administered drugs, resulting in intrauterine 10,11,28 or ectopic [29][30][31] pregnancies. Two of these pregnancies were directly associated with concomitant use of rifampicin.…”

Section: Discussionmentioning

confidence: 99%

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Failure of Implanon® on antituberculous therapy

Gbolade¹

2010

OAJC

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Implanon ® , a contraceptive implant, is increasingly being used because of its efficacy and nonuser-dependent nature. However, as for other steroid contraceptives, its efficacy can be reduced by enzyme-inducing drugs, such as antituberculous medication, resulting in unplanned pregnancy. We present the case of a 27-year-old para 1 + 0 referred to us for termination of a pregnancy that resulted from failure of Implanon during concomitant treatment with Rifinah ® (a rifampicin-isoniazid combination). All health care providers should be aware of the adverse effects of hepatic enzyme inducers on hormonal contraceptives, obtain details of current contraceptive methods from women of reproductive age, and refer them to contraceptive and reproductive health care professionals as appropriate for optimal management. This will ensure that such women do not experience the psychologic trauma of a termination of pregnancy.

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Section: Discussionmentioning

confidence: 99%

“…9 Although there were no failures resulting in pregnancies in the original studies of Implanon, several pregnancies with Implanon in situ were reported in post-marketing surveillance studies in Australia 10 and France. 11 However, most of these Implanon "fail- …”

Section: Introductionmentioning

confidence: 99%

Failure of Implanon® on antituberculous therapy

Gbolade¹

2010

OAJC

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“…Two women with epilepsy (22%) became pregnant during the study period [2,6]. There are only three case series/reports documenting current ETG implant failure in women using AEDs [7-9]. Two case series evaluate multiple causes of failure: 1) Bensouda-Grimaldi et al .…”

Section: Introductionmentioning

confidence: 99%

“…Two case series evaluate multiple causes of failure: 1) Bensouda-Grimaldi et al . [7] document two out of 39 failures in France occurring in women using AEDs [7]; and 2) Harrison-Woolrych and Hill [8] report eight out of greater than 200 unintended pregnancies occurring with ETG implant and AED use [8]. Only one previous case report has exclusively documented a pregnancy in an ETG implant user on AEDs; this occurred 18 months after insertion [9].…”

Section: Introductionmentioning

confidence: 99%

Decreased efficacy of an etonogestrel implant in a woman on antiepileptic medications: a case report

2014

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IntroductionMany antiepileptic drugs decrease the efficacy of combined hormonal contraceptives due to their inducing effect on cytochrome P450 liver metabolism. Less is known about the pharmacokinetics and outcomes of concomitant use of the etonogestrel implant and hepatic enzyme-inducing medications.Case presentationA 22-year-old Hispanic woman with a long-standing seizure disorder treated with carbamazepine for 9 years became pregnant after 25 months of etonogestrel implant use.ConclusionsHepatic enzyme-inducing drugs may reduce the efficacy of contraceptive implants. Contraceptive counseling for patients with medical co-morbidities requiring hepatic enzyme-inducing medications should include this information.

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“…The subdermal contraceptive implant may not be placed in arm at all due to failed insertion. When it occurs, women who received subdermal contraceptive implantation can become pregnant and this may lead to contraception failure and pregnancy [5]. Also, removal of the subdermal contraceptive implant may be very difficult or impossible if the subdermal contraceptive implant is located at unexpected positions.…”

Section: Introductionmentioning

confidence: 99%

Migration of a contraceptive subdermal device into the lung

et al. 2017

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A single-rod subdermal contraceptive implant is usually located around the insertion site, has been usually known to migrate within less than 2 cm of the insertion site and the true migration over 2 cm has been rarely reported. We report a case of migrated radiopaque subdermal contraceptive implant into lung in a 37-year-old woman. On conducted chest computed tomography, subdermal contraceptive implant was in subsegmental branch in left posterior basal segment of lung. Removal of subdermal contraceptive implant in left posterior basal segment of lung by mini-thoracotomy was performed by a chest surgeon. Complications with insertion and removal of subdermal contraceptive implant are rare in the hands of medical professionals familiar with the techniques and these procedures should only be undertaken by those with relevant training. The migration over 2 cm should not occur if the correct subdermal insertion procedure is followed and carried out by a properly trained individual.

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Implanon® : difficultés d'insertion et de retrait, échecs contraceptifs

Cited by 36 publications

References 15 publications

Failure of Implanon® on antituberculous therapy

Failure of Implanon® on antituberculous therapy

Decreased efficacy of an etonogestrel implant in a woman on antiepileptic medications: a case report

Migration of a contraceptive subdermal device into the lung

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Implanon® : difficultés d'insertion et de retrait, échecs contraceptifs

Cited by 36 publications

References 15 publications

Failure of Implanon&reg; on antituberculous therapy

Failure of Implanon&reg; on antituberculous therapy

Decreased efficacy of an etonogestrel implant in a woman on antiepileptic medications: a case report

Migration of a contraceptive subdermal device into the lung

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Product

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About

Failure of Implanon® on antituberculous therapy

Failure of Implanon® on antituberculous therapy