Implantable MEMS acceleration sensor for heart monitoring recent development and outlook

In this review article, we focus on the various types of materials used in biomedical implantable devices, including the polymeric materials used as substrates and for the packaging of such devices. Polymeric materials are used because of the ease of fabrication, flexibility, and their biocompatible nature as well as their wide range of mechanical, electrical, chemical, and thermal behaviors when combined with different materials as composites. Biocompatible and biostable polymers are extensively used to package implanted devices, with the main criteria that include gas permeability and water permeability of the packaging polymer to protect the electronic circuit of the device from moisture and ions inside the human body. Polymeric materials must also have considerable tensile strength and should be able to contain the device over the envisioned lifetime of the implant. For substrates, structural properties and, at times, electrical properties would be of greater concern. Section 1 gives an introduction of some medical devices and implants along with the material requirements and properties needed. Different synthetic polymeric materials such as polyvinylidene fluoride, polyethylene, polypropylene, polydimethylsiloxane, parylene, polyamide, polytetrafluoroethylene, poly(methyl methacrylate), polyimide, and polyurethane have been examined, and liquid crystalline polymers and nanocomposites have been evaluated as biomaterials that are suitable for biomedical packaging (section 2). A summary and glimpse of the future trend in this area has also been given (section 3). Materials and information used in this manuscript are adapted from papers published between 2010 and 2015 representing the most updated information available on each material.

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Section: Methodsmentioning

confidence: 99%

Polymeric Biomaterials for Medical Implants and Devices

Teo

Mishra

Park

et al. 2016

ACS Biomater. Sci. Eng.

617

344

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“…The ongoing evolution in this field is based on the higher technological capabilities of microelectronic technologies, with higher density of integration, and involving a blend of MEMS, packaging and interconnects. The possibility of integrating new dedicated miniature transducers, such as pressure sensors [ 46 ], for arterial blood oxygen saturation, and accelerometers [ 47 ] for heart monitoring or cochlear implementations [ 48 ] are present examples. The progress in miniaturization of lab-on-chip solutions and integrated optics [ 49 ] opens the possibility of advances in new implantable medical devices and new challenges, culminating in the theranostic approach where the implantable will be able to deliver drugs.…”

Section: Description and Challenges Of A Customized Biomedical Implanmentioning

confidence: 99%

Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics

Juanola-Feliu

Miribel-Català

Avilés

et al. 2014

Sensors

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The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device.

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