Implantable Polyurethane Scaffolds Loading with PEG-Paclitaxel Conjugates for the Treatment of Glioblastoma Multiforme

Wu, Hecheng; Feng, Yuan Ping; Song, Xing-Ying; Song, Chun-Yang; Chen, Jinlin; Wang, Yanchao; He, Xueling; Liang, Ruichao; Li, Jiehua; Tan, Hong

doi:10.1007/s10118-022-2695-3

Cited by 11 publications

(6 citation statements)

References 25 publications

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“…A series of WBPU was synthesized using polyethylene glycol (PEG, Mw 1450, Dow Chemical, USA), poly-3-caprolactone (PCL, Mn 2000, Dow Chemical, USA), L-lysine (Emei Biochemical, China), 1,3-propanediol (PDO, Kelong, China) and L-lysine diisocyanate (LDI, Dahong Chemical, China). The WBPU emulsions and scaffolds were prepared in accordance with our recent study [ 26 , 31 ]. Briefly, PEG and PCL were prepolymerized with LDI under a dry nitrogen atmosphere and 1‰ of organic bismuth catalyst at 80°C for 1 h. Then the chain extender PDO was added to react at 65°C for 2 h. Finally, the pre-polyurethane was emulsified by mixing with L-lysine solution for 3 h to obtain polyurethane emulsions.…”

Section: Methodsmentioning

confidence: 99%

Polyurethane scaffold-based 3D lung cancer model recapitulates in vivo tumor biological behavior for nanoparticulate drug screening

Sun,

Wang,

et al. 2023

Regenerative Biomaterials

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Lung cancer is the leading cause of cancer mortality worldwide. Preclinical studies in lung cancer hold the promise of screening for effective anti-tumor agents, but mechanistic studies and drug discovery based on 2D cell models have a high failure rate in getting to the clinic. Thus, there is an urgent need to explore more reliable and effective in vitro lung cancer models. Here, we prepared a series of three-dimensional (3D) waterborne biodegradable polyurethane (WBPU) scaffolds as substrates to establish biomimetic tumor models in vitro. These 3D WBPU scaffolds were porous and could absorb large amounts of free water, facilitating the exchange of substances (nutrients and metabolic waste) and cell growth. The scaffolds at wet state could simulate the mechanics (elastic modulus ∼1.9 kPa) and morphology (porous structures) of lung tissue and exhibit good biocompatibility. A549 lung cancer cells showed adherent growth pattern and rapidly formed 3D spheroids on WBPU scaffolds. Our results showed that the scaffold-based 3D lung cancer model promoted the expression of anti-apoptotic and epithelial–mesenchymal transition (EMT)-related genes, giving it a more moderate growth and adhesion pattern compared to 2D cells. In addition, WBPU scaffold-established 3D lung cancer model revealed a closer expression of proteins to in vivo tumor, including tumor stem cell markers, cell proliferation, apoptosis, invasion, and tumor resistance proteins. Based on these features, we further demonstrated that the 3D lung cancer model established by the WBPU scaffold was very similar to the in vivo tumor in terms of both resistance and tolerance to nanoparticulate drugs. Taken together, WBPU scaffold-based lung cancer model could better mimic the growth, microenvironment, and drug response of tumor in vivo. This emerging 3D culture system holds promise to shorten the formulation cycle of individualized treatments and reduce the use of animals while providing valid research data for clinical trials.

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Section: Methodsmentioning

confidence: 99%

Polyurethane scaffold-based 3D lung cancer model recapitulates in vivo tumor biological behavior for nanoparticulate drug screening

Sun,

Wang,

et al. 2023

Regenerative Biomaterials

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“…25–28 Polyurethane (PU) is a well-recognized biocompatible material that can be used in vivo . 29–32 In addition, it has good degradability and molecular chain tailoring. Therefore, nanoparticles formed by covalently combining TPE with PU can be a promising group of fluorescent imaging dyes.…”

Section: Introductionmentioning

confidence: 99%

A biocompatible polyurethane fluorescent emulsion with aggregation-induced emission for targeted tumor imaging

Wang

et al. 2023

J. Mater. Chem. B

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“…Polyurethane (PU) is known as a promising biodegradable biomaterial with good biocompatibility. 39–41 Therefore, polyurethane-based hydrogels have been widely used in the biomedical field. 42–47 In this work, in order to achieve non-invasive monitoring of biodegradable hydrogels, we prepared an injectable fluorescent PU-OD hydrogel by dynamic cross-linking fluorescent PU emulsion with oxidized dextran (ODex), where the fluorescent PU emulsion was synthesized by using TPE-NH 2 as a chain extender and adipic dihydrazide (ADH) as an end-capping agent.…”

Section: Introductionmentioning

confidence: 99%

A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring

Wang,

Ou,

Wang

et al. 2023

J. Mater. Chem. B

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Implantable Polyurethane Scaffolds Loading with PEG-Paclitaxel Conjugates for the Treatment of Glioblastoma Multiforme

Cited by 11 publications

References 25 publications

Polyurethane scaffold-based 3D lung cancer model recapitulates in vivo tumor biological behavior for nanoparticulate drug screening

Polyurethane scaffold-based 3D lung cancer model recapitulates in vivo tumor biological behavior for nanoparticulate drug screening

A biocompatible polyurethane fluorescent emulsion with aggregation-induced emission for targeted tumor imaging

A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring

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