Implementação da nova regulamentação para prescrição e dispensação de antimicrobianos: possibilidades e desafios

Sampaio, Pamella da Silva; Sancho, Leyla Gomes; Lago, Regina Ferro do

doi:10.1590/1414-462x201800010185

Cited by 25 publications

(20 citation statements)

References 4 publications

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“…It provides clinical success with minimal toxicity and reduces the impact on microbial resistance [21]. The indiscriminate use of antibiotics is considered by the World Health Organization (WHO) to be a global problem and, as a consequence, has led to the growth of bacterial resistance [22] and the emergence of superbugs [23]. One of the issues related to the endodontic treatment of deciduous teeth is a color change.…”

Section: Albicansmentioning

confidence: 99%

Do Different Proportions of Antibiotics in the CTZ Paste Interfere with the Antimicrobial Action? In Vitro Study

Oliveira

Omena

Lira

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the antimicrobial action of the CTZ paste in three different proportions by diffusion in agar with the microorganisms: Enterococcus faecalis, Escherichia coli, and Candida albicans. Material and Methods: Three different proportions of antibiotics were tested: GROUP A-CTZ paste in the ratio of 33.33% chloramphenicol + 33.33% tetracycline + 33.33% zinc oxide, mixed with 2 drops of eugenol (1:1:1 ratio); GROUP B-CTZ paste in the proportion of 25% chloramphenicol + 25% tetracycline + 50% zinc oxide, mixed with 2 drops of eugenol (1: 1: 2 ratio); GROUP C-CTZ paste with 13% chloramphenicol + 13% tetracycline + 74% Zinc Oxide, mixed with 2 drops of eugenol (1:1:6 ratio); PC GROUP-Positive Control (0.12% Chlorhexidine); and NC GROUP-Negative Control (0.9% Saline solution). Data were analyzed through descriptive statistics (means and standard deviation). The one-way ANOVA and Tukey's test were used, with a significance level of 5%. Results: No statistical differences for Enterococcus faecalis between groups A, B, and C (p = 0.1986) were found. There were statistical differences for Escherichia coli between groups B and C (p = 0.029), and for Candida albicans between groups A and C (p = 0.006). Groups A, B, and C had significant differences with both Positive and Negative Controls for all the microorganisms. Conclusion: The three different ratios of CTZ paste showed antimicrobial efficacy against Enterococcus faecalis, Escherichia coli, and Candida albicans microorganisms.

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Section: Albicansmentioning

confidence: 99%

Do Different Proportions of Antibiotics in the CTZ Paste Interfere with the Antimicrobial Action? In Vitro Study

Oliveira

Omena

Lira

et al. 2019

Pesqui. bras. odontopediatria clín. integr.

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“…Bacterial resistance is a phenomenon caused by the evolution or adaptation of microorganisms to antibiotics, through several molecular mechanisms [1]. Infections caused by multi-drug resistant microorganisms represent one of the major public health problems worldwide, both because of increased morbidity and mortality and due to high hospitalization costs [2,3].…”

Section: Introductionmentioning

confidence: 99%

Photoinduced Antibacterial Activity of the Essential Oils from Eugenia brasiliensis Lam and Piper mosenii C. DC. by Blue Led Light

Silva¹,

Castro²,

Dantas³

et al. 2019

Antibiotics

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The objective of this work was to evaluate the phytochemical composition and the antibacterial and antibiotic-modulating activities of the essential oils of Eugenia brasiliensis Lam (OEEb) and Piper mosenii C. DC (OEPm) singly or in association with blue LED (Light-emitting diode) light. The antibacterial and antibiotic-modulatory activities of the essential oils on the activity of aminoglycosides were evaluated to determine the minimum inhibitory concentration (MIC, μg/mL) in the presence or absence of exposure to blue LED light. The chemical analysis showed α-pinene and bicyclogermacrene as major constituents of OEPm, whereas α-muurolol was the main compound of OEEb. Both OEEb and OEPm showed MIC ≥ 512 μg/mL against the strains under study. However, the association of these oils with the blue LED light enhanced the action of the aminoglycosides amikacin and gentamicin. In conclusion, the association of aminoglycosides with the blue LED light and essential oils was effective against resistant bacteria.

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“…A alta dispensação de antibióticos, bem como o uso prolongado e prescrição inadequados, somados à pressão da indústria farmacêutica para disseminar a sua utilização, tornaram a resistência bacteriana uma preocupação mundial e um severo problema de saúde pública. (14) O crescimento da resistência bacteriana tem gerado um impacto negativo significativo sobre os recursos destinados à saúde e, mesmo em países desenvolvidos, tem promovido aumento da taxa de mortalidade causada por infecções bacterianas resistentes. (15,16) Convém salientar que a prescrição medicamentosa por um profissional habilitado é essencial para atenuar a resistência microbiana e reduzir possíveis efeitos adversos causados pelas interações medicamentosas.…”

Section: Discussionunclassified

The dispensation of drugs in the primary health care of the Single Health System/ Dispensação de medicamentos na atenção primária do Sistema Único de Saúde

et al. 2021

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Objetivo: analisar a dispensação de medicamentos na atenção primária do Sistema Único de Saúde em um município do Estado de São Paulo. Metodologia: realizou-se análise documental dos boletins de movimentação de medicamentos das farmácias das 19 Unidades Básicas de Saúde do município de Araçatuba-SP, sede do Departamento Regional de Saúde II-SP, durante 12 meses. Os medicamentos foram agregados segundo o sistema de classificação Anatomical Therapeutic Chemical e ação farmacológica. Analisou-se o total de medicamentos dispensados e o saldo final dos principais tipos de fármacos. Resultados: foram dispensados 60.479.959 medicamentos, sendo 53,10% antibióticos, 15,42% anti-hipertensivos, 5,09% antidepressivos, 4,81% hipoglicemiantes, 3,16% ansiolíticos, 2,82% complexos vitamínicos e minerais, 2,17% antipsicóticos, 1,99% analgésicos, dentre outros tipos (11,45%). Permaneceram disponíveis 8.778.863 medicamentos, sendo os anti-hipertensivos, antidepressivos e ansiolíticos os que representam a maior proporção entre estes. Os antibióticos apresentaram a menor proporção de unidades disponíveis, com aproximadamente 2%. Os hipoglicemiantes apresentaram maior diversidade de fármacos sem unidades disponíveis para dispensação. Conclusão: os principais tipos de medicamentos dispensados foram antibióticos, anti-hipertensivos, antidepressivos e hipoglicemiantes. A dispensação de medicamentos foi satisfatória, considerando que mesmo os medicamentos que não apresentaram saldo residual positivo foram substituídos por outros de propriedades farmacológicas similares.

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Implementação da nova regulamentação para prescrição e dispensação de antimicrobianos: possibilidades e desafios

Cited by 25 publications

References 4 publications

Do Different Proportions of Antibiotics in the CTZ Paste Interfere with the Antimicrobial Action? In Vitro Study

Do Different Proportions of Antibiotics in the CTZ Paste Interfere with the Antimicrobial Action? In Vitro Study

Photoinduced Antibacterial Activity of the Essential Oils from Eugenia brasiliensis Lam and Piper mosenii C. DC. by Blue Led Light

The dispensation of drugs in the primary health care of the Single Health System/ Dispensação de medicamentos na atenção primária do Sistema Único de Saúde

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