Last year was another tumultuous year, with the evolution of SARS-CoV-2, ongoing war and destruction in Ukraine, economic hardship throughout the world, mind-numbing recurrences of racial and ethnic violence, accumulating evidence of the devastating effects of climate change, and wide political and social divisions. At the same time, there have been positive developments regarding management of COVID-19, including new treatments for COVID-19 to replace ones no longer effective, increasing immunity among many populations from immunization and infection, and increasing recognition of the need to understand and treat post-COVID-19 condition symptoms.These circumstances and events have served to further energize the editors and staff of JAMA Network Open to pursue our mission "to improve health, health care, and health equity worldwide through open access dissemination of high quality, innovative, general medical research and commentary by and for a broad range of clinicians, researchers, policy makers, and public health and health care leaders."We remain deeply committed to addressing racism in medicine, health care, and society both in the US and abroad. 1,2 Monica Vela, MD, joined us this year as JAMA Network Open Diversity, Equity, and Inclusion associate editor. In this role, she collaborates with the rest of the editors and with Preeti