Implementation of a standardized protocol for prevention and management of oral mucositis in patients undergoing hematopoietic cell transplantation

Bhatt, Valkal; Vendrell, Nancy; Nau, Karen M.; Crumb, Deborah J.; Roy, Vivek

doi:10.1177/1078155209348721

Cited by 52 publications

(46 citation statements)

References 15 publications

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“…This suggestion is based on two case series [16,20], four non-randomized clinical trials [14,15,19,21], and three RCTs [17, 18; 22 supplemented by 23] (Table 2). The collective evidence was scored as level III.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Peterson

Öhrn

Bowen

et al. 2012

Support Care Cancer

115

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Purpose This systematic review analyzed the strength of the literature and defined clinical practice guidelines for the use of oral cryotherapy for the prevention and/or treatment of oral mucositis caused by cancer therapy. Methods A systematic review on relevant oral cryotherapy studies indexed prior to 31 December 2010 was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) using OVID/MEDLINE, with publications selected for review based on defined inclusion and exclusion criteria. Findings from the reviewed studies were integrated into guidelines based on the overall level of evidence for each intervention. Guidelines were classified into three types: recommendation, suggestion, or no guideline possible. of oral cryotherapy to prevent oral mucositis in patients receiving high-dose melphalan as conditioning regimen with or without total body irradiation for HCST was revised from the 2007 guidelines. No guideline was possible for any other intervention, due to insufficient evidence. Conclusions The evidence continues to support the use of oral cryotherapy for prevention of oral mucositis in patients receiving bolus 5-FU chemotherapy or high-dose melphalan. This intervention is consistent with the MASCC/ISOO guidelines published in 2007. The literature is limited by the fact that utilization of a double-blind study design is not feasible. Future studies that compare efficacy of oral cryotherapy with other mucositis agents in patients receiving chemotherapy with relatively short plasma half-lives would be useful.

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Section: Resultsmentioning

confidence: 99%

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Peterson

Öhrn

Bowen

et al. 2012

Support Care Cancer

115

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show abstract

“…We need to become better at preventing and treating mucositis through improved cooperation with the hospital dentistry department and by developing care plans. 21,29 The study population changed over time; 3 years after the transplantation 30 patients had died and a further 13 patients had dropped out of the study, leaving a study population of 53 patients. We found no significant differences between the patients who dropped out and those alive.…”

Section: Discussionmentioning

confidence: 99%

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

Frödin

Börjeson

Lyth

et al. 2010

Bone Marrow Transplant

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Few studies have evaluated long-term health-related quality of life (HRQL) in patients during auto-SCT. This prospective study examined HRQL in 96 eligible patients before, during and up to 3 years after auto-SCT. The aim of the study was to make a comprehensive assessment of the frequency and severity of different symptoms in patients undergoing auto-SCT. The European Organization for Treatment and Research of Cancer Quality of Life Questionnaire (EORTC QLQ C-30) was administered 13 times. The second week during treatment was the period when patients had the lowest HRQL regarding both total quality of life and function and symptom scales. The patients recovered quickly and just two months after transplantation the baseline values were restored. Three years after transplantation most of the items in the questionnaire had stabilized, except role function and dyspnea, which had improved. There were significant differences between multiple myeloma (MM) and lymphoma patients' physical function, quality of life, fatigue and pain during week 2. At the 3-year follow-up, lymphoma patients indicated a better HRQL than MM patients. The quick recovery of patients after transplantation suggests that treatment is well tolerated; however, the supportive care could be improved at week 2, especially for the lymphoma patients.

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“…Four intervention components showed a tendency to be efficacious: self-care instructions, pre-aHSCT dental treatment [15][16][17][18][19][20] instructions regarding tongue and toothbrushing technique, and the use of foam brushes to reduce pain or bleeding [17,18,21].…”

Section: Introductionmentioning

confidence: 99%

An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study

Leppla

Geest

Fierz

et al. 2015

Support Care Cancer

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Implementation of a standardized protocol for prevention and management of oral mucositis in patients undergoing hematopoietic cell transplantation

Cited by 52 publications

References 15 publications

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

A prospective evaluation of patients' health-related quality of life during auto-SCT: a 3-year follow-up

An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study

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