Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production

Ovdiichuk, Olga; Mallapura, Hemantha; Pineda, Florian; Hourtané, Virginie; Långström, Bengt; Halldin, Christer; Nag, Sangram; Maskali, Fatiha; Karcher, Gilles; Collet, Charlotte

doi:10.1039/d1lc00148e

Cited by 15 publications

(22 citation statements)

References 33 publications

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“…As the earliest devices developed in this field of research, flow-based microfluidic reactors are currently the most mature and widespread technology available for the microfluidic synthesis of PET probes. So far, studies have proven its ability to radiolabel with 18 F [29] , 11 C [25] , and 89 Zr [30] in a broad range of reactions, solvents, temperatures, and reagents. Nevertheless, future progress toward a widespread commercial application will require substantial research and development efforts to overcome several problems, including large dead volumes, common channel blockage, inability to maintain a steady hydrodynamic pressure, and joint leakage due to high pressures.…”

Section: Prof Mei Tian Is Currently Working As a Distinguished Profes...mentioning

confidence: 99%

“…Cassete design of the iMiDEV batch reactor; [29] Reproduced with the permission of the Royal Society of Chemistry. as shown in Figure 9b.…”

Section: Figurementioning

confidence: 99%

“…In addition, Ovdiichuk et al built a new fully automated microfluidic platform (iMiDEV) for small-scale radiopharmaceut-icals production in both liquid and gas phases. [29] The device shown in Figure 7 is laid out with three different sizes of pipes, and their maximum width and height are 600 × 400 μm (big channels), 800 × 400 μm (mixed channels), and 200 × 200 μm (small channels), respectively. This device can synthesize singledose [ 18 F]NaF in an average radiochemical yield of 87% (decay corrected) within 8 min.…”

Section: Batch-flow Microfluidicsmentioning

confidence: 99%

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Recent Advances in Microfluidic Devices for the Radiosynthesis of PET‐imaging Probes

Elkawad

Tian

et al. 2022

Chemistry An Asian Journal

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In order to accommodate the growing demand for positron emission tomography (PET), it will be necessary to create innovative radiochemical and engineering technologies to optimize the manufacture and development of PET probes. Microfluidic devices allow radiosynthesis to be performed in microscale amounts, significantly impacting PET tracer production. Compared to traditional methods, microfluidic devices can produce PET tracers in a shorter time, higher yields, with lower reagent consumption, higher molar activity, and faster purification. This review examines microfluidic devices from an engineering perspective. Recently developed microfluidic radiosynthesis devices are classified into three categories according to their reaction volume: continuous-flow, batch-flow, and droplet-based microreactors. The principles of device architecture, radiosynthesis process, and the relative strengths and limitations of each category are emphasized by citing typical examples. Finally, the possible future applications of this technology are outlined. A flexible, miniature, fully automated radiochemical microfluidic platform will offer more straightforward and cheaper molecular imaging procedures and the potential for precision medicine that could allow operators to create customized tracers for individual patient doses.

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Section: Prof Mei Tian Is Currently Working As a Distinguished Profes...mentioning

confidence: 99%

“…Cassete design of the iMiDEV batch reactor; [29] Reproduced with the permission of the Royal Society of Chemistry. as shown in Figure 9b.…”

Section: Figurementioning

confidence: 99%

Section: Batch-flow Microfluidicsmentioning

confidence: 99%

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Recent Advances in Microfluidic Devices for the Radiosynthesis of PET‐imaging Probes

Elkawad

Tian

et al. 2022

Chemistry An Asian Journal

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“…Indeed, most studies investigating radiopharmaceutical compounds on-chip developed microfluidic microreactors or quality-control devices, mainly for positron emission tomography (PET) radiotracers. [105][106][107][108][109][110][111][112][113][114] For example, Taggart et al engineered a microfluidic platform for radiation detection, and used it to quantify the activity of PET tracers 2-[18F] fluoro-2-deoxy-D-glucose and [68Ga] gallium-citrate as well as single photon emission computed tomography (SPECT) radiotracer [99mTc] pertechnetate (Fig. 2E).…”

Section: Sources For Radiation Therapy Modality/techniquementioning

confidence: 99%

Radiotherapy on-chip: microfluidics for translational radiation oncology

et al. 2022

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“…The first one is the macrofluidic miniAIO ® (Trasis), and it has been used for production of numerous 68 Ga-radiopharmaceuticals such as [ 68 Ga]Ga-PSMA-11 [22,23] and [ 68 Ga]Ga-NODAGA-RGD [24]. The second one is iMiDEV ™ (PMB Alcen), a new commercially available synthesizer using microfluidic technology for radiopharmaceutical production [25]. The same simplified radiosynthesis strategy was successfully implemented onto both radiosynthesis modules.…”

Section: Introductionmentioning

confidence: 99%

Fully Automated Macro- and Microfluidic Production of [68Ga]Ga-Citrate on mAIO® and iMiDEVTM Modules

et al. 2022

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68Ga-radionuclide has gained importance due to its availability via 68Ge/68Ga generator or cyclotron production, therefore increasing the number of 68Ga-based PET radiopharmaceuticals available in clinical practice. [68Ga]Ga-citrate PET has been shown to be prominent for detection of inflammation/infection of the musculoskeletal, gastrointestinal, respiratory, and cardiovascular systems. Automation and comparison between conventional and microfluidic production of [68Ga]Ga-citrate was performed using miniAllInOne® (Trasis) and iMiDEV™ (PMB-Alcen) synthetic modules. Fully automated procedures were elaborated for cGMP production of tracer. In order to facilitate the tracer approval as a radiopharmaceutical for clinical use, a new method for radiochemical identity determination by HPLC analysis to complement standard TLC radiochemical purity measurement was developed. The results showed higher radiochemical yields when using MCX cartridge on the conventional module mAIO®, while a PS-H+ cation exchanger was shown to be preferred for integration into the microfluidic cassette of iMiDEV™ module. In this study, the fully automated radiosynthesis of [68Ga]Ga-citrate using different synthesizers demonstrated reliable and reproducible radiochemical yields. In order to demonstrate the applicability of [68Ga]Ga-citrate, in vitro and in vivo studies were performed showing similar characteristics of the tracer obtained using macro- and microfluidic ways of production.

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Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production

Abstract: We present an efficient fully automated sodium [18F]fluoride radiosynthesis on a new iMiDEV™ cassette-based microfluidic platform.

Cited by 15 publications

References 33 publications

Recent Advances in Microfluidic Devices for the Radiosynthesis of PET‐imaging Probes

Recent Advances in Microfluidic Devices for the Radiosynthesis of PET‐imaging Probes

Radiotherapy on-chip: microfluidics for translational radiation oncology

Fully Automated Macro- and Microfluidic Production of [68Ga]Ga-Citrate on mAIO® and iMiDEVTM Modules

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