2008
DOI: 10.1258/jms.2008.007063
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Implementation of the newborn screening programme for sickle cell disease in England: results for 2003-2005

Abstract: Objectives This paper reports early screening results from the newborn sickle cell disease screening programme recently implemented in England. Setting England. Screening is offered at 5-8 days of age as part of the existing bloodspot test and offered to all babies irrespective of ethnicity. Methods The laboratory methods recommended are high performance liquid chromatography (HPLC) and iso-electric focusing (IEF). 15 Two methods of analysis must be applied to all screen positive results. The conditions scree… Show more

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Cited by 35 publications
(30 citation statements)
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“…A detailed implementation plan was developed which included training of staff responsible for taking samples (predominantly midwives) and providing laboratory set-up costs, development of materials for parents, recruitment of counsellors and funding of laboratories as described elsewhere 4 5. Standards for the linked newborn and antenatal programme6 and for the overall bloodspot programme3 are available in various publications.…”
Section: Methodsmentioning
confidence: 99%
“…A detailed implementation plan was developed which included training of staff responsible for taking samples (predominantly midwives) and providing laboratory set-up costs, development of materials for parents, recruitment of counsellors and funding of laboratories as described elsewhere 4 5. Standards for the linked newborn and antenatal programme6 and for the overall bloodspot programme3 are available in various publications.…”
Section: Methodsmentioning
confidence: 99%
“…7 A clinical rationale for disclosure is rarely advanced, or discussed cf. 8 Furthermore, despite the prevalence of NBS-generated carrier results (UK figures indicate approximately 6500 SCD carriers identified for 250 SCD cases 9 ), the bulk of available evidence regarding the effects of identifying carriers through NBS focuses on the case of cystic fibrosis (CF). 10 This evidence suggests that a minority of parents and providers might misunderstand the meaning of carrier status, increasing parental stress and anxiety and the risk of the 'vulnerable child' syndrome.…”
Section: Introductionmentioning
confidence: 99%
“…If needed, however, significant additional contrast can be achieved by the simple expedient of applying an illumination source at an oblique angle to the sample (data not shown). This mobile phone microscopy system could prove to be particularly useful for point-of-care screening of newborns for sickle cell disorders, to identify and treat patients before the onset of symptoms in resource-poor nations, a process already mandatory in the United States and other developed countries [17], [18], [19].…”
Section: Resultsmentioning
confidence: 99%