Implementing Precision Medicine: The Ethical Challenges

Korngiebel, Diane M.; Thummel, Kenneth E.; Burke, Wylie

doi:10.1016/j.tips.2016.11.007

Cited by 43 publications

(31 citation statements)

References 38 publications

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“…Moreover, to maintain the quality of healthcare remains problematic issues; and v. Additionally, no systems exist that ensure patients' right regarding financial savings for those diagnostic rest required for PM 101 . Similarly, multiple studies regarding precision medicine concluded that ethical issues regarding data protection and safety 91,102 . Additionally, it also apprehends to future debate about genetically engineered patients and creation for super-human 91 .…”

Section: Changeless Of Precision Medicine In Lowerand Middle-income Cmentioning

confidence: 99%

Prospects and Challenges of Precision Medicine in Lower- and Middle-Income Countries: A Brief Overview

Haque

Islam

Sartelli

et al. 2019

Bangladesh J Med Sci

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The trend of NCDs in most LMIC countries is slowly but gradually follows that of in the developed countries. There are four significant diseases reported by WHO, which are equally common, such as CVDs, diabetes, cancer, and chronic respiratory disease that causes widespread early death & morbidity. Indeed, it incurs an overwhelming financial burden to most countries in the world. The rise of drug-resistant microbes is another major problem. To overcome this issue, precision medicine (PM) comes into play whereby individual variability in genes, environment, lifestyle, and nutrition of each person is considered for disease treatment & prevention. PM provides a personalized approach, the right treatment to the right people at the right time. Many wealthy countries in the West have started adopting PM though the initial cost is high, ultimately, in the long run, will reduce the healthcare cost by getting rid of the ineffective treatment strategies. However, the PM in LMICs is still at an early stage due to issues such as lack of populationspecific data, competency, expertise, and poor financial support. Bangladesh Journal of Medical Science Vol.19(1) 2020 p.32-47

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Section: Changeless Of Precision Medicine In Lowerand Middle-income Cmentioning

confidence: 99%

Prospects and Challenges of Precision Medicine in Lower- and Middle-Income Countries: A Brief Overview

Haque

Islam

Sartelli

et al. 2019

Bangladesh J Med Sci

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show abstract

“…No single unifying theme unites this body of work, but a number of diverse themes run through it. In addition to quality improvement, researchers continue to address the challenges of big data in an era of precision medicine, including the provision of tools to help patients and clinicians make good decisions using large amounts of possibly unfamiliar data [6]. Continued expansion of this technology to different clinical contexts, such as emergency medicine, is another hallmark of activity in CDS [7].…”

Section: Introductionmentioning

confidence: 99%

Advances in Clinical Decision Support: Highlights of Practice and the Literature 2015-2016

Jenders¹

2017

Yearb Med Inform

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SummaryIntroduction: Advances in clinical decision support (CDS) continue to evolve to support the goals of clinicians, policymakers, patients and professional organizations to improve clinical practice, patient safety, and the quality of care. Objectives: Identify key thematic areas or foci in research and practice involving clinical decision support during the 2015-2016 time period. Methods: Thematic analysis consistent with a grounded theory approach was applied in a targeted review of journal publications, the proceedings of key scientific conferences as well as activities in standards development organizations in order to identify the key themes underlying work related to CDS. Results: Ten key thematic areas were identified, including: 1) an emphasis on knowledge representation, with a focus on clinical practice guidelines; 2) various aspects of precision medicine, including the use of sensor and genomic data as well as big data; 3) efforts in quality improvement; 4) innovative uses of computer-based provider order entry (CPOE) systems, including relevant data displays; 5) expansion of CDS in various clinical settings; 6) patient-directed CDS; 7) understanding the potential negative impact of CDS; 8) obtaining structured data to drive CDS interventions; 9) the use of diagnostic decision support; and 10) the development and use of standards for CDS. Conclusions: Active research and practice in 2015-2016 continue to underscore the importance and broad utility of CDS for effecting change and improving the quality and outcome of clinical care. KeywordsClinical decision support, quality improvement, medical order entry systems Yearb Med Inform 2017:125-32 http://dx

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“…Diane Korngiebel, DPhil, University of Washington, is one of several people who are exploring the ethical challenges of precision medicine. 5 COMMENTARY to know the future (genetic markers of cancer in your future) and its challenge to our humanness, is at the heart of many people's reluctance to embrace this new technology. When a patient can get his or her own genetic profile online, complete with diagnoses and carrier states, will primary care physicians be necessary?…”

mentioning

confidence: 99%

Is Precision Medicine Consistent With Primary Care?

King

2019

Fam Med

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Implementing Precision Medicine: The Ethical Challenges

Cited by 43 publications

References 38 publications

Prospects and Challenges of Precision Medicine in Lower- and Middle-Income Countries: A Brief Overview

Prospects and Challenges of Precision Medicine in Lower- and Middle-Income Countries: A Brief Overview

Advances in Clinical Decision Support: Highlights of Practice and the Literature 2015-2016

Is Precision Medicine Consistent With Primary Care?

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