Implementing the EU Chemicals Strategy for Sustainability: The case of food contact chemicals of concern

Zimmermann, Lisa; Scheringer, Martin; Geueke, Birgit; Boucher, Justin M.; Parkinson, Lindsey Viann; Groh, Ksenia J.; Muncke, Jane

doi:10.1016/j.jhazmat.2022.129167

Cited by 36 publications

(22 citation statements)

References 31 publications

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“…As has been shown for many types of polymers used as FCMs, unreacted monomers, reaction intermediates, and degradation products migrate from polymers, especially after extended use and/or under certain conditions (e.g., high temperature). 12,42,43,176 In addition to lowering PFAS exposure to consumers, government regulations and voluntary initiatives limiting or banning the use of PFASs in FCMs/FCAs may contribute to positive knock-on effects both up and down the supply chain. One could expect these actions to reduce exposure for people working in fluorochemical manufacturing facilities and/or at facilities where PFAS-containing FCMs are used, made, and disposed of.…”

Section: Caveats Of Comparing Concentrations Of Pfass In Fcmsmentioning

confidence: 99%

“…41 In brief, we recorded whether they are classified as carcinogenic, mutagenic, or toxic to reproduction (CMR) and have specific organ toxicity (STOT), endocrine disrupting properties, persistence and bioaccumulation-related hazards (PBT, vPvB), and/or persistent and mobile properties (PMT/ vPvT). The consulted hazard data sources are listed in the Supporting Information, and the applied methodology was further detailed by Zimmermann et al 42 and Geueke et al 43 ■ RESULTS AND DISCUSSION PFASs Detected in FCMs. Based on 47 studies, we have identified 552 entries for PFASs detected in migrates and/or extracts of FCMs from the FCCmigex database, consisting of 68 different PFASs found in paper/board, coated metal, and/ or plastic FCMs.…”

Section: ■ Introductionmentioning

confidence: 99%

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Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

Phelps,

Parkinson,

Boucher

et al. 2024

Environ. Sci. Technol.

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PFASs are linked to serious health and environmental concerns. Among their widespread applications, PFASs are known to be used in food packaging and directly contribute to human exposure. However, information about PFASs in food packaging is scattered. Therefore, we systematically map the evidence on PFASs detected in migrates and extracts of food contact materials and provide an overview of available hazard and biomonitoring data. Based on the FCCmigex database, 68 PFASs have been identified in various food contact materials, including paper, plastic, and coated metal, by targeted and untargeted analyses. 87% of these PFASs belong to the perfluorocarboxylic acids and fluorotelomer-based compounds. Trends in chain length demonstrate that long-chain perfluoroalkyl acids continue to be found, despite years of global efforts to reduce the use of these substances. We utilized ToxPi to illustrate that hazard data are available for only 57% of the PFASs that have been detected in food packaging. For those PFASs for which toxicity testing has been performed, many adverse outcomes have been reported. The data and knowledge gaps presented here support international proposals to restrict PFASs as a group, including their use in food contact materials, to protect human and environmental health.

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Section: Caveats Of Comparing Concentrations Of Pfass In Fcmsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

Phelps,

Parkinson,

Boucher

et al. 2024

Environ. Sci. Technol.

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“…To find such discrepancies, we compared the chemical classification of aniline determined by ECHA (European Chemical Agency) from the European Union (EU) 45 and the National Institute of Technology and Evaluation (NITE) from Japan. 46 Table 5 compares physical, health, and environmental hazards for aniline in the EU and Japan. Both authorities' classifications are not entirely uniform but share some similarities.…”

Section: Current Hazard Communication Standardsmentioning

confidence: 99%

Toxicity, Hazards, and Safe Handling of Primary Aromatic Amines

Gheni,

Ali,

et al. 2023

ACS Chem. Health Saf.

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Aromatic amines (AAs) are an important class of organic compounds that find their application in various industries, such as dye production, rubber manufacturing, and pharmaceutical synthesis. Despite the various applications, they significantly harm human health and the environment. This article provides an overview of the toxicity, hazards, and safe handling of some primary aromatic amines (PAAs), focusing on representative examples, such as aniline, toluidine, nitroaniline, chloroaniline, and naphthylamine. The carcinogenicity and mutagenicity of PAAs are a matter of concern that impacts the health of workers who are occupationally exposed to such chemicals. Nonoccupational exposure to tobacco smoke and household products also causes health issues in elderly patients who remain indoors. Water and soil contamination by these pollutants adversely affects aquatic organisms and groundwater quality. Thus, proper handling and disposal protocols must be followed to minimize their impact on human health and the environment. Additionally, this review discusses the discrepancies between the European Union (EU) and Japan’s hazard categorization for aniline as a specific example. The information presented in this review emphasizes the importance of understanding toxicity, hazards, and safe handling practices associated with PAAs to ensure their responsible use and mitigate potential risks.

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“…[1] There has been a growing concern over the potential impact of endocrine-disrupting chemicals (EDCs) on human health, especially reproduction, as well as the consequences of contaminating the surrounding environment. [2,3] Bisphenol A (BPA) is well recognized as one of the most ubiquitous EDCs owing to its wide applications in plastics. [4] Humans are extensively exposed to BPA via access to plastic bottles, food containers, hygiene products, and many other plastic-related goods.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction

Fang,

You,

Luo

et al. 2023

Adv Healthcare Materials

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Bisphenol A (BPA) is a prevalent endocrine disruptor found in natural environments. Exposure to BPA has been associated with male infertility. The natural phytochemical icariin (ICA) has demonstrated significant promise for the treatment of male infertility. However, its effectiveness is limited due to its low bioavailability, poor water solubility, and insufficient targeting abilities. Herein, novel nanoparticles are generated from the natural silk fibroin, which are used to load ICA. The efficient drug delivery system (ICA‐SNPs) result in significantly focused drug distribution to spermatogonium, enhancing the anti‐infertility properties of ICA, and can effectively mitigate spermatogenesis dysfunction induced by BPA, control serum sex hormone levels, and enhance testicular ultrastructure. Additionally, the ICA‐SNPs restore spermatogenesis dysfunction primarily via the hormone biosynthesis, spermatogonium meiosis process, and glycerophospholipid metabolism.

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Implementing the EU Chemicals Strategy for Sustainability: The case of food contact chemicals of concern

Cited by 36 publications

References 31 publications

Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

Per- and Polyfluoroalkyl Substances in Food Packaging: Migration, Toxicity, and Management Strategies

Toxicity, Hazards, and Safe Handling of Primary Aromatic Amines

Silk Fibroin Encapsulated Icariin Nanoparticles Mitigate Bisphenol A‐Induced Spermatogenesis Dysfunction

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