Implication of dietary phthalates in breast cancer. A systematic review

Zuccarello, Pietro; Conti, Gea Oliveri; Cavallaro, Federico; Copat, Chiara; Cristaldi, Antonio; Fiore, Maria

doi:10.1016/j.fct.2018.06.011

Cited by 51 publications

(24 citation statements)

References 75 publications

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“…As one of the PAEs’ target is thyroid, these compounds seem to play a major role in the onset of thyroid cancer, being able to activate estrogen receptor, induce VEGF-mediated angiogenesis [ 106 ].…”

Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Giuliani

Zuccarini

Cichelli

et al. 2020

IJERPH

246

119

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Phthalates are a huge class of chemicals with a wide spectrum of industrial uses, from the manufacture of plastics to food contact applications, children’s toys, and medical devices. People and animals can be exposed through different routes (i.e., ingestion, inhalation, dermal, or iatrogenic exposure), as these compounds can be easily released from plastics to water, food, soil, air, making them ubiquitous environmental contaminants. In the last decades, phthalates and their metabolites have proven to be of concern, particularly in products for pregnant women or children. Moreover, many authors reported high concentrations of phthalates in soft drinks, mineral waters, wine, oil, ready-to-eat meals, and other products, as a possible consequence of their accumulation along the food production chain and their accidental release from packaging materials. However, due to their different physical and chemical properties, phthalates do not have the same human and environmental impacts and their association to several human diseases is still under debate. In this review we provide an overview of phthalate toxicity, pointing out the health and legal issues related to their occurrence in several types of food and beverage.

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Section: Toxicological Aspects and Human Health Effectsmentioning

confidence: 99%

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Giuliani

Zuccarini

Cichelli

et al. 2020

IJERPH

246

119

View full text Add to dashboard Cite

show abstract

“…Despite the current ban for the use of some phthalates such as Di-(2-Ethylhexyl) phthalate (DEHP) in children’s toys in US and EU, many types of phthalates are still employed in various other industries, i.e., in cosmetics, paints, food packaging, cleaning agents, and medical devices (tablet coatings, blood bags and tubes, drugs packaging, etc.). Phthalates aren’t accumulating in the body, but they are metabolized and mainly excreted in the urine (within hours or few days) [7,21]. Phthalates have endocrine-disrupting ability, and thyroid is one of the major target organs.…”

Section: Chemical Pollutantsmentioning

confidence: 99%

“…Literature shows that many phthalates (including butyl benzyl phthalate (BBP) and DEHP) are able to bind and activate the estrogen receptor and angiogenesis, and tumor progression processes through the regulation of vascular endothelium growth factor (VEGF). In fact, these compounds induced a dose-dependent increase of VEGF secretion in MELN’s cells (Melbourne cells model) with constant expression of ERα receptor (estrogen receptor alpha) [7].…”

Section: Chemical Pollutantsmentioning

confidence: 99%

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Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review

Fiore

Conti

Caltabiano³

et al. 2019

IJERPH

Self Cite

144

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Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such as organochlorines and pesticides, are able to disrupt thyroid function. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid, transport proteins, replace thyroxin, and disrupt thyroid function as phthalates and bisphenolates do, highly mimicking thyroid hormones. A better knowledge of environmental risks represents a very important tool for cancer prevention through true risks prevention and management. This approach is very important because of the epigenetic origin’s theory of cancer. Therefore, the aim of this review was study the association between environmental agents and thyroid cancer promotion.

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“…Widespread human and environmental exposure to phthalates has been described, with ingestion being the main route of administration (Stojanoska, Milosevic, Milic, & Abenavoli, 2017;Toni et al, 2017). Furthermore, phthalates are also associated with erectile dysfunction in human males, along with breast and other cancers, while also being responsible for various deleterious effects in murine models and cell lines (Absalan et al, 2017;Lopez et al, 2017;Rocha et al, 2017;Zuccarello et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A novel natural coating for food preservation: Effectiveness on microbial growth and physicochemical parameters

Carocho

Heleno

Rodrigues

et al. 2019

LWT

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This work describes the development of a sustainable and natural coating solution based on iota-carrageenan and rosemary extract intended to preserve cooked ham through dipping. Upon comparing the physical and microbial load changes between this solution and the traditional plastic wrap along 15 consecutive days, the results showed that in terms of microbial load the samples treated with the developed solution had a lower microbial count. Furthermore, only slight changes in moisture loss and hardness were observed between samples using the two tested preservation strategies. Colour analysis revealed that dipped samples presented reduced lightness, with a tendency to avoid shifting to a blue tone over the 15-days of storage. This work indicates that natural polymers combined with natural antimicrobials and antioxidants can be employed to reduce the dependence on synthetic polymers and offer feasible solutions to be applied at an industrial level.

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Implication of dietary phthalates in breast cancer. A systematic review

Cited by 51 publications

References 75 publications

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review

A novel natural coating for food preservation: Effectiveness on microbial growth and physicochemical parameters

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