Implication of Pituitary Vasoactive Intestinal Peptide in Dopaminergic Inhibition of Estrogen-Induced Pituitary Hyperplasia and Vascular Endothelial Growth Factor Expression

Gómez, Oscar; Balsa, José Antonio

doi:10.1159/000083658

Cited by 6 publications

(3 citation statements)

References 67 publications

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“…These data suggest that pituitary VIP mediates the effect of E on lactotrope hyperplasia, pituitary TGF-b1, and angiogenesis [32]. It has been also shown that E in vitro enhances and bromocriptine reduces not only expression and release of VIP in anterior pituitary cell culture, but the endothelial growth factor as well [33]. Diagrams showing the effect of sexual steroid treatments on the basal PRL levels in various experimental groups.…”

Section: Discussionmentioning

confidence: 87%

Effect of concomitant progesterone administration or the effect of removal of estrogen capsule on changes caused by long-term estrogen treatment in pituitary VIP immunoreactivities

Heinzlmann

Köves

Nagy

2010

Endocr

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In the anterior pituitary besides the classical tropic hormones, peptides of a small molecular weight are also synthesized. One of them is the vasoactive intestinal polypeptide (VIP). VIP immunoreactivity is readily detected in human and monkey pituitaries; however, in the rat VIP immunoreactive cells were observed in about 50% of intact rats. In estrogen treated rats VIP immunoreactive cells were observed in the anterior pituitary of all animals. In this work, we have examined the effect of long-term sexual steroid treatments on the VIP immunoreactivity of the anterior pituitary using diethylstilbestrol (DES) or progesterone (P) filled capsules. The effectiveness of steroid treatments was tested by the measurement of plasma prolactin (PRL) level and by the appearance of prolactinoma. DES enhanced the plasma PRL level and 5 months later it induced prolactinomas, the concomitant P treatment prevented both the elevation of plasma PRL level and the formation of prolactinomas. These results indicated that there was enough steroid in the capsules. There was a positive correlation between the duration of DES influence and the number of VIP immunoreactive cells. Two months after the implantation of DES there was a considerable number of VIP cells in the anterior pituitary, and 5 months after implantation the number of VIP cells was greatly increased so as to form a VIP-oma. Concomitant implantation of P prevented the formation of VIP-oma. Two months after the implantation, the DES capsule was removed. Already 2 months after removal the number of VIP cells approximated to the control level. It has been concluded that P can prevent the undesired effect of DES not only on the PRL, but on the VIP immunoreactivity as well.

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Section: Discussionmentioning

confidence: 87%

Effect of concomitant progesterone administration or the effect of removal of estrogen capsule on changes caused by long-term estrogen treatment in pituitary VIP immunoreactivities

Heinzlmann

Köves

Nagy

2010

Endocr

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“…This is the first report that the TH polymorphism is associated with risk of GC. Previous studies have shown that DA strongly and selectively inhibits the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) [20][21][22], which promote the growth and progression of GC. Therefore, it is possible that TH contributes to the susceptibility to GC by regulating the expression of DA.…”

Section: Discussionmentioning

confidence: 99%

Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population

Xie

et al. 2007

Clin. Exper.Med.

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Gastric cancer (GC) is a common and complex disease caused by multifactors. The aim of our study was to investigate the association of the common polymorphisms detected in insulin-like growth factor (IGF)-II, IGF-1 receptor, insulin-like growth factor binding protein 1 (IGFBP1), insulin (INS) and tyrosine hydroxylase (TH) with susceptibility to GC in a northwestern Chinese population. One hundred and fifty-four GC patients and 166 healthy controls were investigated in our study. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The frequencies of CC and CT genotypes of TH were significantly higher in GC patients than in controls, as the odds ratios were 3.03 (95%CI 1.438-6.362, P=0.003) and 1.97 (95%CI 1.218-3.167, P=0.005), respectively. No association was found between the polymorphisms of IGF-II ApaI, insulin-like growth factor-1 receptor MnlI, IGFBP1 Bgl II and INS-23HphI and the development of GC. The presence of CC and CT genotypes of TH was associated with a significantly increased risk of GC. But the polymorphisms of other genes detected did not indicate an increased risk of GC in the investigated population.

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“…205). VIP is also produced by the lactotrophs, where it maintains elevated basal PRL release (206). VIP acts by increasing intracellular cAMP, followed by PKA activation.…”

Section: Prl Releasing/regulating Factorsmentioning

confidence: 99%

Antagonism of Taxol Cytotoxicity by Prolactin: Implication for Patient Resistance to Chemotherapy

Ben‐Jonathan¹

2008

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution is Unlimited SUPPLEMENTARY NOTES ABSTRACTThe refining industry in Iran is facing a crisis caused by a growing shortfall in production capacity for gasoline and other light fuels to meet rapidly growing domestic demand. The industry is locked into a repetitive cycle of decline due to under investment in new facilities and total capacity, massive government energy and automotive subsidies that encourage continued growth in demand, and a poor investment climate that discourages badly needed foreign investment in the refining industry. The shortfall in refining capacity causes the government to import fuel, the costs of which are growing beyond the government's ability to control. This refining crisis creates an opportunity for the United States and its allies to exercise strategic patience in trying to influence the Iranian government's behavior in a direction more favorable to our interests. The Iranian government has demonstrated an ability to act pragmatically in order to stave off economic dislocation in the past. It is reasonable to assume they will do so again in response to the economic threat posed by the refining crisis. While a policy of strategic patience carries risk, the available evidence demonstrates that the current program of sanctions and economic pressure are likely to force a favorable change in Iranian behavior. The refining industry in Iran is facing a crisis caused by a growing shortfall in production capacity for gasoline and other light fuels to meet rapidly growing domestic demand. The industry is locked into a repetitive cycle of decline due to under investment in new facilities and total capacity, massive government energy and automotive subsidies that encourage continued growth in demand, and a poor investment climate that discourages badly needed foreign investment in the refining industry. The shortfall in refining capacity causes the government to import fuel, the cost of which are growing beyond the government's ability to control. This refining crisis creates an opportunity for the United States and its allies to exercise strategic patience in trying to influence the Iranian government's behavior in a direction more favorable to our interests. The Iranian government has demonstrated an ability to act pragmatically in order to stave off economic dislocation in the past....

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Implication of Pituitary Vasoactive Intestinal Peptide in Dopaminergic Inhibition of Estrogen-Induced Pituitary Hyperplasia and Vascular Endothelial Growth Factor Expression

Cited by 6 publications

References 67 publications

Effect of concomitant progesterone administration or the effect of removal of estrogen capsule on changes caused by long-term estrogen treatment in pituitary VIP immunoreactivities

Effect of concomitant progesterone administration or the effect of removal of estrogen capsule on changes caused by long-term estrogen treatment in pituitary VIP immunoreactivities

Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population

Antagonism of Taxol Cytotoxicity by Prolactin: Implication for Patient Resistance to Chemotherapy

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