Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women

Abstract

Genome-wide association studies have identified loci that are firmly associated with obesity. The Src-homology-2 B adaptor protein 1 (SH2B1) loci is abundantly expressed in the brain, liver, heart, muscle, and fat tissues. Gestational diabetes mellitus (GDM) is a growing health concern that usually appears during the latter half of pregnancy, and it is characterized by carbohydrate intolerance of variable severity. The SH2B1 gene polymorphism has been linked with an increased risk of weight gain in several but not all population studies. This study aimed to investigate the genetic association of rs4788102 variants in the SH2B1 gene with GDM in Saudi pregnant women. Genomic DNA samples from 200 women with GDM and 300 women without GDM were genotyped using the TaqMan method. The distribution of the GG, GA, and AA genotypes was significantly different between GDM and non-GDM women (p < 0.05). Thus, we identified rs4788102 variants as additional risk factors for GDM in Saudi women, and we suggest that these variants may have a prognostic value.

Medical nutrition treatment of women with gestational diabetes mellitus by a telemedicine system based on smartphones

“…In our study, multiple linear regression analysis suggested that OGTT2h, PROM and self‐monitoring of blood glucose (SLMG) times were risk factors for gestational age at delivery. This result was consistent with the findings of Alhakeem . Yao‐Jun et al .…”

“…This result was consistent with the findings of Alhakeem. 11 Yao-Jun et al 12 also showed that premature rupture was the main risk factor for premature delivery. In addition, obstetricians should pay attention to the OGTT2h blood sugar level to increase the gestational age at delivery.…”

Association of the SH2B1 rs7359397 Gene Polymorphism with Steatosis Severity in Subjects with Obesity and Non-Alcoholic Fatty Liver Disease

“…This gene family contains three members of adaptor proteins (SH2B1, 2 and 3), being highly expressed in the liver [22]. Its potential mechanism may be as an adaptor protein, wherein SH2B1 is implicated in several transduction processes such as enhancing JACK2 or the PI3-kinase pathway [23,24]. A genetic disruption of this gene has been associated with severe leptin resistance, energy imbalance, obesity and type 2 diabetes in humans, which are common comorbidities related to NAFLD [24].…”

“…Its potential mechanism may be as an adaptor protein, wherein SH2B1 is implicated in several transduction processes such as enhancing JACK2 or the PI3-kinase pathway [23,24]. A genetic disruption of this gene has been associated with severe leptin resistance, energy imbalance, obesity and type 2 diabetes in humans, which are common comorbidities related to NAFLD [24]. In addition, it has been recently published that SH2B1 can regulate the migration, proliferation and differentiation of cells, which could influence the development of some cancers [23].…”

“…In humans, studies of this genetic variant linked to NAFLD have not been reported to date. However, among the SH2B1 genetic variants identified as related to obesity traits, the polymorphism rs7359397 has been associated with glycosylated hemoglobin [25] and insulin sensitivity [24,25].…”