Implication of stringent response in the increase of mutability of the whiG and whiH genes during Streptomyces coelicolor development

Genay, Magali; Decaris, Bernard; Dary, Annie

doi:10.1016/j.mrfmmm.2007.03.016

Mutation Research/Fundamental and Molecular Mechanisms of Mutag

2007

DOI: 10.1016/j.mrfmmm.2007.03.016

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Implication of stringent response in the increase of mutability of the whiG and whiH genes during Streptomyces coelicolor development

Magali Genay¹,

Bernard Decaris²,

Annie Dary³

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Cited by 3 publications

References 37 publications

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Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10

Liu

Yuan

et al. 2015

Appl Microbiol Biotechnol

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The roles of many sigma factors are unclear in regulatory mechanism of secondary metabolism in Streptomyces. Here, we report the regulation network of a group 3 sigma factor, WhiGch, from a natamycin industrial strain Streptomyces chattanoogensis L10. WhiGch regulates the growth and morphological differentiation of S. chattanoogensis L10. The whiG ch deletion mutant decreased natamycin production by about 30 % and delayed natamycin production more than 24 h by delaying the growth. Overexpression of the whiG ch gene increased natamycin production in large scale production medium by about 26 %. WhiGch upregulated the transcription of natamycin biosynthetic gene cluster and inhibited the expression of migrastatin and jadomycin analog biosynthetic polyketide synthase genes. WhiGch positively regulated natamycin biosynthetic gene cluster by directly binding to the promoters of scnC and scnD, which were involved in natamycin biosynthesis, and these binding sites adjacent to translation start codon were determined. Thus, this paper further elucidates the high natamycin yield mechanisms of industrial strains and demonstrates that a valuable improvement in the yield of the target metabolites can be achieved through manipulating the transcription regulators.

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Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10

Liu

Yuan

et al. 2015

Appl Microbiol Biotechnol

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Degeneration of industrial bacteria caused by genetic instability

Peng

Liang

2020

World J Microbiol Biotechnol

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The evolution of morphological development is congruent with the species phylogeny in the genus Streptomyces

Wang

Zhang

et al. 2023

Front. Microbiol.

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As the canonical model organism to dissect bacterial morphological development, Streptomyces species has attracted much attention from the microbiological society. However, the evolution of development-related genes in Streptomyces remains elusive. Here, we evaluated the distribution of development-related genes, thus indicating that the majority of these genes were ubiquitous in Streptomyces genomes. Furthermore, the phylogenetic topologies of related strict orthologous genes were compared to the species tree of Streptomyces from both concatenation and single-gene tree analyses. Meanwhile, the reconciled gene tree and normalization based on the number of parsimony-informative sites were also employed to reduce the impact of phylogenetic conflicts, which was induced by uncertainty in single-gene tree inference based merely on the sequence and the bias in the amount of phylogenetic information caused by variable numbers of parsimony-informative sites. We found that the development-related genes had higher congruence to the species tree than other strict orthologous genes. Considering that the development-related genes could also be tracked back to the common ancestor of Streptomyces, these results suggest that morphological development follows the same pattern as species divergence.

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Implication of stringent response in the increase of mutability of the whiG and whiH genes during Streptomyces coelicolor development

Cited by 3 publications

References 37 publications

Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10

Sigma factor WhiGch positively regulates natamycin production in Streptomyces chattanoogensis L10

Degeneration of industrial bacteria caused by genetic instability

The evolution of morphological development is congruent with the species phylogeny in the genus Streptomyces

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