Implications of Gene Inheritance Patterns on the Heterosis of Abdominal Fat Deposition in Chickens

Mai, Chunning; Wen, Chaoliang; Sun, Chang; Chen, Sirui; Yang, Ning

doi:10.3390/genes10100824

Cited by 18 publications

(20 citation statements)

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“…A previous study showed that high-parent dominance DEG are important in heterosis in Drosophila melanogaster and contribute specifically to BW heterosis (Wu et al, 2016). In chickens, heterosis of abdominal fat percentage was 69.28 to 154.71% in reciprocal crosses and highparent dominance accounted for approximately 50% of nonadditive genes in reciprocal crosses (Mai et al, 2019). A threshold of gene expression 1.25-fold change was used to classify inheritance categories in our study and previous studies (McManus et al, 2010;Gu et al, 2019).…”

Section: Discussionmentioning

confidence: 68%

Inheritance patterns of leukocyte gene expression under heat stress in F1 hybrid cattle and their parents

Zhang

Huang

Chen

et al. 2020

Journal of Dairy Science

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Crossbreeding capitalizes on heterosis effects and results in increased performance of crossbred animals. Dominance hypothesis and overdominance hypothesis are 2 common models proposed to explain heterosis. Differential gene expression between parents and hybrids is hypothesized to be responsible for heterosis. This study aimed to investigate the heat tolerance and inheritance patterns of leukocyte transcriptomics in F 1 hybrid cattle (Angus males × Droughtmaster females) and their parents Red Angus (AN) and Droughtmaster (DR) under heat stress. According to the respiratory rate and heat tolerance coefficient index, DR was better adapted to heat stress than AN. The physiological responses to heat stress of F 1 hybrids were similar to AN. We identified 802 differentially expressed genes in leukocytes between AN and DR under heat stress using mRNA sequencing. Compared with AN, upregulated genes in DR were enriched in biological processes of response to stress, external and chemical stimulus, and cytokine, cell surface receptor signaling pathway, and cardiovascular system development. In contrast, upregulated genes in AN were enriched in B cell activation and regulation of B cell activation. Gene expression levels can be inherited additively or nonadditively and are classified into additive (35%), dominance (44%), and overdominance and underdominance (18%) modes in F 1 hybrids and their parents. Inheritance patterns of gene expression showed that 97% (249/255) of the dominant genes were classified as paternal AN dominant in hybrids. The paternal imprinted PEG10 gene and its regulatory transcription factor MYC showed an AN dominant expression pattern. The MYC interacted with most AN dominant genes. These transcriptomic analyses revealed that DR and AN had specific cellu-lar and humoral immunity and cardiovascular systems development function under heat stress. Inheritance pattern analyses from gene expression partly explained phenotypic differences between parents and F 1 hybrids. The paternal imprinted PEG10 gene interaction with transcription factor MYC may contribute to explaining paternal dominant gene expression in hybrids.

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Section: Discussionmentioning

confidence: 68%

Inheritance patterns of leukocyte gene expression under heat stress in F1 hybrid cattle and their parents

Zhang

Huang

Chen

et al. 2020

Journal of Dairy Science

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“…Pattern of differential expression of genes are potential mechanisms underlying heterosis ( Mai et al., 2019 ; Zhou et al., 2019 ). Antimullerian hormone primarily regresses the right oviduct of hens during development in addition to completely inhibiting its development in roosters ( Johnson et al., 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Hybrids generated by crossing elite laying chickens exhibited heterosis for clutch and egg quality traits

et al. 2020

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Crossbreeding advantage in hybrids compared with their parents, termed heterosis, has been exhaustively exploited in chicken breeding over the last century. Reports for crossbreeding of elite laying chickens covering rearing and laying period remain infrequent. In this study, resource populations of Rhode Island Red ( RIR ) and White Leghorn ( WL ) pure-bred chickens were reciprocally crossed to generate 4 distinct groups that were evaluated for prelaying growth, egg production, and egg quality. Birds monitored for prelaying growth consists of 105 (RIR), 131 (WL), 207 (RIR × WL) and 229 (WL × RIR), and 30 pullets from each group were evaluated. Egg laying records were collected from 102, 89, 147, and 191 hens in the 4 populations, respectively. In addition, expression of 5 candidate genes for egg production in the ovarian follicles was measured by RT-qPCR. Results showed that BW of hatched chicks in the WL line was higher than the other populations. However, the 2 crossbreds grew faster than WL purebred throughout the prelaying period. Low to medium heterosis was observed for BW and body length before the onset of lay. White Leghorn and the hybrids commenced laying earlier than RIR pullets and egg production traits were favorable in the crossbreds compared with purebreds. Heterosis for egg number and clutch size was moderate in WL × RIR but low in RIR × WL hens. Expression of antimullerian hormone gene was high in WL and RIR × WL hybrids, suggesting WL parent-specific enhancing dominant expression. Shell weight was higher in the crossbreds than purebreds at 52 wk of age, but RIR hens laid eggs with higher shell ratio than the other populations ( P < 0.05). Conversely, WL and the hybrids had higher eggshell strength than RIR birds ( P < 0.05). Eggshell strength was the only egg quality trait that showed heterosis above 10% in WL × RIR hybrids at 32 and 52 wk of age. White Leghorn × RIR hens demonstrated higher percent heterosis for economic traits than birds of the reciprocal hybrid. This means that RIR breed is a better dam than a sire line for growth, egg laying, and egg quality traits.

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“…In addition, the pattern of enhancing dominance was more prevalent than suppressing dominance in most groups, indicating that up-regulated dominant events potentially play important roles in heterosis. Previous studies on body weight in Drosophila and gene expression modes in the liver of chickens have shown similar results (Mai et al, 2019). However, due to different cluster methods used, other studies have reported that additivity is the main gene expression pattern in embryonic chickens (Wu et al, 2016;Zhuo et al, 2019).…”

Section: Discussionmentioning

confidence: 73%

“…Studies on Camellia and coffee have indicated that the non-additive expression prevailed over other patterns ( Marie-Christine et al, 2015 ; Zhang et al, 2019 ). On the other hand, several studies have suggested that additivity is the predominant genetic pattern in maize, rice, and cotton ( Swanson-Wagner et al, 2006 ; Li et al, 2008 ; Rapp et al, 2009 ), while divergent outcomes suggest that additive or high parent-dominance is the major pattern in chickens ( Mai et al, 2019 ; Zhuo et al, 2019 ). Most previous studies have identified different inheritance patterns based on gene expression, and there is rarely a transcriptomic study that investigates AS event patterns, considering the association between AS and gene regulation at the post-transcriptional level.…”

Section: Introductionmentioning

confidence: 99%

Transcriptome-Wide Analyses Identify Dominant as the Predominantly Non-Conservative Alternative Splicing Inheritance Patterns in F1 Chickens

2021

Front. Genet.

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Transcriptome analysis has been used to investigate many economically traits in chickens; however, alternative splicing still lacks a systematic method of study that is able to promote proteome diversity, and fine-tune expression dynamics. Hybridization has been widely utilized in chicken breeding due to the resulting heterosis, but the dynamic changes in alternative splicing during this process are significant yet unclear. In this study, we performed a reciprocal crossing experiment involving the White Leghorn and Cornish Game chicken breeds which exhibit major differences in body size and reproductive traits, and conducted RNA sequencing of the brain, muscle, and liver tissues to identify the inheritance patterns. A total of 40 515 and 42 612 events were respectively detected in the brain and muscle tissues, with 39 843 observed in the liver; 2807, 4242, and 4538 events significantly different between two breeds were identified in the brain, muscle, and liver tissues, respectively. The hierarchical cluster of tissues from different tissues from all crosses, based on the alternative splicing profiles, suggests high tissue and strain specificity. Furthermore, a comparison between parental strains and hybrid crosses indicated that over one third of alternative splicing genes showed conserved patterns in all three tissues, while the second prevalent pattern was non-additive, which included both dominant and transgressive patterns; this meant that the dominant pattern plays a more important role than suppression. Our study provides an overview of the inheritance patterns of alternative splicing in layer and broiler chickens, to better understand post-transcriptional regulation during hybridization.

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Implications of Gene Inheritance Patterns on the Heterosis of Abdominal Fat Deposition in Chickens

Cited by 18 publications

References 50 publications

Inheritance patterns of leukocyte gene expression under heat stress in F1 hybrid cattle and their parents

Inheritance patterns of leukocyte gene expression under heat stress in F1 hybrid cattle and their parents

Hybrids generated by crossing elite laying chickens exhibited heterosis for clutch and egg quality traits

Transcriptome-Wide Analyses Identify Dominant as the Predominantly Non-Conservative Alternative Splicing Inheritance Patterns in F1 Chickens

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