2018
DOI: 10.4172/neuropsychiatry.1000344
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Implications of Polymorphisms in the CRHR1 Gene on the Hypothalamic-Pituitary-Adrenal Axis Functioning in Postpartum Depression

Abstract: Objective:This study was aimed at assessing the association of the TAT haplotype of the corticotropinreleasing hormone receptor type 1 (CRHR1) with the function of the hypothalamic-pituitaryadrenal (HPA) axis in depressive and euthymic women in the remote postpartum period. Methods:The sample (mean age = 27.9 ± 5.3 years) consisted of 37 depressed postpartum women, of which 26 had one or two copies of the TAT haplotype (D-TAT ) and 20 without the TAT haplotype (E-TAT 0 ). Salivary cortisol samples were collect… Show more

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