Implications of Population Screening for Thalassemias and Hemoglobinopathies in Rural Areas of West Bengal, India: Report of a 10-Year Study of 287,258 Cases

Maji, Suman Kumar; Dolai, Tuphan Kanti; Pradhan, Sayantan; Maity, Abhijit; Mandal, Soma; Mondal, Tamanash; Manna, Simi; Mandal, Prakas Kumar

doi:10.1080/03630269.2020.1831530

Cited by 7 publications

(10 citation statements)

References 13 publications

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“…The earliest birth prevalence data reported was for the period 1989–1992 22 (Oman) and the latest for 2020 23 (Thailand). For overall prevalence, data availability ranged from 1995 22 (Oman) to 2020 (England, 24 India, 25 Saudi Arabia 26 ). From the 70 included publications, 23 (33%) papers reported population‐based estimates of the overall point or period prevalence of alpha‐ and/or beta‐thalassemia.…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studies reported data on the prevalence of beta‐thalassemia in Asia from non–population‐based, selected samples of subjects 25,52,53,55–63 . The prevalence of beta‐thalassemia intermedia was described in a number of studies by retrospectively determining phenotype (Table S7).…”

Section: Resultsmentioning

confidence: 99%

“…51 Twelve studies reported data on the prevalence of betathalassemia in Asia from non-population-based, selected samples of subjects. 25,52,53,[55][56][57][58][59][60][61][62][63] The prevalence of beta-thalassemia intermedia was described in a number of studies by retrospectively determining phenotype (Table S7). Prevalence ranged from 14 per 100 000 pregnant women and husbands from the Guangdong province in China in 2012 53 to 615 per 100 000 individuals from northern India and Nepal in 2008.…”

Section: Prevalence Of Alpha-and Beta-thalassemia Reported In Non-pop...mentioning

confidence: 99%

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Epidemiology of clinically significant forms of alpha‐ and beta‐thalassemia: A global map of evidence and gaps

Musallam¹,

Lombard

Kistler³

et al. 2023

American J Hematol

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This systematic literature review assessed the global prevalence and birth prevalence of clinically significant forms of alpha‐ and beta‐thalassemia. Embase, MEDLINE, and the Cochrane Library were searched for observational studies published January 1, 2000, to September 21, 2021. Of 2093 unique records identified, 69 studies reported across 70 publications met eligibility criteria, including 6 records identified from bibliography searches. Thalassemia prevalence estimates varied across countries and even within countries. Across 23 population‐based studies reporting clinically significant alpha‐thalassemia (e.g., hemoglobin H disease and hemoglobin Bart's hydrops fetalis) and/or beta‐thalassemia (beta‐thalassemia intermedia, major, and/or hemoglobin E/beta‐thalassemia), prevalence estimates per 100 000 people ranged from 0.2 in Spain (over 2014–2017) to 27.2 in Greece (2010–2015) for combined beta‐ plus alpha‐thalassemia; from 0.03 in Spain (2014–2017) to 4.5 in Malaysia (2007–2018) for alpha‐thalassemia; and from 0.2 in Spain (2014–2017) to 35.7 to 49.6 in Iraq (2003–2018) for beta‐thalassemia. Overall, the estimated prevalence of thalassemia followed the predicted pattern of being higher in the Middle East, Asia, and Mediterranean than in Europe or North America. However, population‐based prevalence estimates were not found for many countries, and there was heterogeneity in case definitions, diagnostic methodology, type of thalassemia reported, and details on transfusion requirements. Limited population‐based birth prevalence data were found. Twenty‐seven studies reported thalassemia prevalence from non–population‐based samples. Results from such studies likely do not have countrywide generalizability as they tended to be from highly specific groups. To fully understand the global prevalence of thalassemia, up‐to‐date, population‐based epidemiological data are needed for many countries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Prevalence Of Alpha-and Beta-thalassemia Reported In Non-pop...mentioning

confidence: 99%

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Epidemiology of clinically significant forms of alpha‐ and beta‐thalassemia: A global map of evidence and gaps

Musallam¹,

Lombard

Kistler³

et al. 2023

American J Hematol

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“…Various studies have reported the prevalence of various hemoglobinopathies in west Bengal ranging from 6 -11.46%. [22][23][24] 24 The high prevalence of microcytic indices in tribal children suggests the need for screening and counseling for hemoglobinopathies in this vulnerable group to curtail the prevalence of hemoglobinopathies and their consequences. There was no macrocytic anemia (MCV >100fL) found in this cohort.…”

Section: Resultsmentioning

confidence: 99%

The prevalence of anemia among the tribal children from the western districts of West Bengal, India

Dolai

Mondal

Jain

et al. 2021

Int J Community Med Public Health

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Background: Tribal population in West Bengal constitutes a significant proportion (5.1%) and the vulnerable group because of lower socio-economic status, poor literacy rate and malnutrition. The present study was conducted to evaluate hemoglobin level and prevalence of anemia among the tribal children from the western districts of West Bengal, India.Methods: A cross-sectional study was conducted on school going (class I to class VIII) tribal children (≥5 to <13years) during March 2019 to February 2020. A complete blood count was done by automated blood cell counter and anemia was classified as per WHO criteria. They were also tested for markers of common nutritional anemias (serum ferritin, serum vitamin B12 and serum folate). Data entry and analysis was done on SPSS version 15. A p-value of <0.05 was considered statistically significant.Results: Total 1, 010 tribal children were included with male:female=1:1.35. Among these, 46.34% (n=468) children had anemia. Among all anemic children 47.65% (n=223), 51.93% (n=243/468) and 0.42% (n=2) respectively had mild, moderate and severe anemia. There was a high prevalence (81.68%) of microcytic red blood cells in the total cohort; among anemic children, 53.94% have microcytosis while no macrocytosis was revealed. Among all grade anemias, iron, folate and vitamin B12 deficiency were found in 44.65% (n=209/468), 13.24% (n=62/468) and 25% (n=117/468) respectively.Conclusions: The prevalence of anemia among tribal children of West Bengal is a matter of concern. The high prevalence of microcytic indices in non-anemic population highlights the dire need for screening for the causes of anemia in this population.

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“…It constitutes a major health problem in areas with high carrier frequency, most of which occur in developing countries. [4][5][6][7] Guangdong province, which is located in the southern part of China, has a high prevalence of thalassemia. Shaoguan, a northern city in Guangdong province, is the border area between Guangdong, Hunan, and Jiangxi provinces of China.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of hemoglobinopathies and thalassemias in Northern Guangdong Province, China

Fan

et al. 2021

Medicine

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To detect the molecular characterization of hemoglobinopathies and thalassemias in Northern Guangdong Province of China.We recruited 10,285 subjects who were screened for hemoglobin (Hb) variants and thalassaemia genotypes in the outpatient department of Yuebei People's Hospital from January 2018 to December 2020. The subjects collected venous blood samples for blood cell parameter analysis and Hb electrophoresis analysis. When the average red blood cell volume is <82 fL, or the average red blood cell Hb is <27 pg, or HbA2 > 3.5%, or HbA2 < 2.5%, or HbF > 2.0%, the screening is positive if one of them is satisfied. All subjects who were screened positive were tested for the thalassaemia gene by gap-polymerase chain reaction, PCR-based reverse dot blot, and DNA sequencing.Among all subjects screened, the overall prevalence of hemoglobinopathies and thalassemias were 0.46% (47/10,285) and 21.02% (2162/10,285) in Northern Guangdong Province. We found that Hb Q-Thailand is the most common, and other types of hemoglobinopathies are followed by Hb E, Hb New York, Hb G-Chinese, Hb G-Coushatta, Hb J-Bangkok, Hb J-Broussais, Hb Ottawa, and Hb G-Taipei. We identified 1340 cases (13.03%) of α-thalassemia, mainly includes --SEA deletion (71.64%), –α3.7 deletion (12.01%), –α4.2 deletion (4.78%). And identified 652 cases (6.34%) of β-thalassemia, the most prevalent being CD 41/42(-TTCT) (35.89%), IVS-II-654 (C > T) (33.44%), CD 17 (A > T) (10.28%) and –28(A > G) (9.66%). Furthermore, there are 170 cases (1.65%) of α combined β thalassaemia. In addition, we found a rare case with –80 (T > A) of β-thalassemia. The results of this study found a high prevalence of hemoglobinopathies and thalassemias in Northern Guangdong Province, China. There were some differences molecular characterizations of thalassemia in different areas of China.Our results enriched the related information of hemoglobinopathies and thalassemias in the region, which provided valuable references for the prevention and control of thalassemia.

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Implications of Population Screening for Thalassemias and Hemoglobinopathies in Rural Areas of West Bengal, India: Report of a 10-Year Study of 287,258 Cases

Cited by 7 publications

References 13 publications

Epidemiology of clinically significant forms of alpha‐ and beta‐thalassemia: A global map of evidence and gaps

Epidemiology of clinically significant forms of alpha‐ and beta‐thalassemia: A global map of evidence and gaps

The prevalence of anemia among the tribal children from the western districts of West Bengal, India

Molecular characterization of hemoglobinopathies and thalassemias in Northern Guangdong Province, China

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