2024
DOI: 10.1101/2024.08.12.24311198
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Implications of progressive lung damage and post-TB sequelae for the health benefits of prompt TB diagnosis in high HIV prevalence settings: a mathematical modeling analysis

Melike Hazal Can,
Sedona Sweeney,
Brian W. Allwood
et al.

Abstract: Background:Untreated pulmonary tuberculosis (TB) causes ongoing lung damage, which may persist after treatment. Conventional approaches for assessing TB health effects may not fully capture these mechanisms. We evaluated how TB–associated lung damage and post–TB sequalae affect the lifetime health consequences of TB in high HIV prevalence settings.Methods:We developed a microsimulation model representing dynamic changes in lung function for individuals evaluated for TB in routine clinical settings. We paramete… Show more

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