Implications of the changes in serum neutrophil gelatinase‐associated lipocalin and cystatin <scp>C</scp> in patients with chronic kidney disease

Shen, Shuijuan; Hu, Zuo-Xiang; Li, Qinghua; Wang, Shimin; Song, Chuyi; Wu, Dongdong; He, Jing; Guan, Jichao; Shan, Juanping

doi:10.1111/nep.12203

Cited by 20 publications

(16 citation statements)

References 15 publications

(35 reference statements)

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“…Many tissue-and/or serum-derived biomarkers are known to have important clinical applications for monitoring the severity of disease and prognostication [17][18][19] . Although numerous serum biomarkers are independently predictive of the prognostic outcomes in patients with cardiovascular disease or CKD [20][21][22][23] , few such markers are applicable in cases of CRS 24) . Microparticles (MPs), small membrane-enclosed vesicles ranging in size from 0.1 m to 1.0 m, are derived from the plasma membrane and released by activated and/or apoptotic cells.…”

Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31 CD42b AN V ) and platelet-derived apoptotic microparticles (PDA-MPs; CD31 CD42b AN V ) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CAD CKD ) and 10 patients without CAD and CKD were enrolled into group 3 (CAD CKD ). Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p 0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p 0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p 0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p 0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p 0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p 0.033). Conclusions:The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD. J Atheroscler Thromb, 2015; 22: 247-256.

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Section: Blood Sampling For Biochemistry Blood Cell Count Study and mentioning

confidence: 99%

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Chen

Wallace

et al. 2015

JAT

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“…Нарастание экскреции с мочой BGAL-HUMAN -β-галактозидазы имеет место при введении повреждении почечной ткани нефротоксическими агентами [39]. K1C27-HUMAN-кератин I типа 27 нарастает при ремоделировании тканевых структур [28]; RS27A-HUMAN -рибосомальный белок убиквитин-40S S27a характеризует степень тубулоинтерстициального и клубочкового повреждения, приводящего к почечной недостаточности и гибели животных [40].…”

Section: результатыunclassified

Identification of Biomarkers of Renal Parenchyma Damage in the Urine of Patients With Chronic Pyelonephritis by Elisa and Mass Spectrometry Methods

et al. 2019

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We performed clinical observations and laboratory examination of 22 patients with chronic pyelonephritis (chronic renal failure, CRF) and 30 healthy individuals. The patients with CRF were examined twice. The first group (Group I) included patients with exacerbation of the disease. The comparison series (Group II) was represented by the same patients who were examined 1.5-3 months after completion of treatment, without clinical exacerbation of chronic pyelonephritis (CPN). Laboratory signs of acute renal damage were not detectable in all the patients examined. Concentrations of VEGF, MCP-1, IL-8 and IL-18 were determined in urine samples of all examined persons by ELISA technique. Protein spectrum of urine was assessed in six patients from Group I, and in six cases of Group II by means of mass spectrometry, using Agilent 1100 chromatographic device, and LTQ-FT Ultra hybrid mass spectrometer. The results of parallel determination of urine proteins by the two methods have shown that the evolving CPN exacerbation is associated with local secondary immune deficiency at the level of renal tubular urothelium. Determination of urine proteome by means of mass spectrometry in exacerbating disease allows identify the proteins associated with damage to epithelial lining of renal tubules and development of local immune response.

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“…Another evidence suggests that NGAL may even be involved as a mediator of CKD progression, serum NGAL was significantly correlated with the severity of renal damage and the progression of renal function deterioration. 18 Cys-C is a small molecule (13 kDa) that is filtered and metabolized after tubular absorption. 19,20 It is a sensitive biomarker of kidney function in mild-tomoderate kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study of Huai Qi Huang granules delay the development of primary glomerular diseases in human

Duan

Pan

et al. 2014

Renal Failure

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Objective: To evaluate the effects of Huai Qi Huang (HQH) granules on primary glomerulonephritis patients, and to discuss its possible mechanisms. Method: Sixteen patients diagnosed with primary glomerular disease between December 2011 and December 2012 were enrolled. Their blood and urine samples were collected at day 0 (the baseline levels), 30, and 90 of receiving HQH granules orally. Levels of creatinine and cystatin C (Cys-C) in serum and urine, and total protein and albumin in urine were measured by automatic biochemical analyzer. Neutrophil gelatinase-associated lipocalin (NGAL) in serum and urine was tested by ELISA; serum malondialdehyde (MDA) was measured by thiobarbituric acid method, the erythrocyte count in urine was calculated under light microscope. Results: Serum levels of creatinine, MDA, Cys-C and NGAL at day 30 and 90 were significantly lower than the baseline levels. Urinary levels of Cys-C, NGAL, total protein, albumin and erythrocyte counts were also decreased; level of estimated glomerular filtration (eGFR) was increased. Conclusion: HQH granules have certain effect on delaying the development of primary glomerular disease with mild proteinuria and hematuresis in patients. This study may supply a new treatment for primary glomerular diseases.

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Implications of the changes in serum neutrophil gelatinase‐associated lipocalin and cystatin C in patients with chronic kidney disease

Abstract: Serum NGAL is an effective biomarker for detecting early-stage renal damage in CKD patients. Serum NGAL was significantly correlated with the severity of renal damage and the progression of renal function deterioration.

Cited by 20 publications

References 15 publications

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Identification of Biomarkers of Renal Parenchyma Damage in the Urine of Patients With Chronic Pyelonephritis by Elisa and Mass Spectrometry Methods

Preliminary study of Huai Qi Huang granules delay the development of primary glomerular diseases in human

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