Importance for experiments in human medicine of imaging modalities for macroanatomical and histological study of rabbit suprarenal glands

Abstract

The morphological characteristics of the rabbit adrenal glands are currently investigated using routine imaging modalities. The aim of the study was to collect and interpret major findings and information in the literature on the rabbit as an animal model for investigations in humans. The suprarenal glands of thirty-four mature, clinically healthy New Zealand rabbits were studied using anatomical, routine histology, radiology, computed tomography, ultrasonography, and magnetic resonance imaging methods. The results demonstrated that the rabbit suprarenal glands are paired ellipsoid organs. The right gland was close to the right kidney, whereas the left gland was located at a distance from the left kidney. The capsule was composed of dense connective tissue. The parenchyma consisted of three zones: zona glomerulosa, zona fasciculate, and zona reticularis. The medulla was in the center of the glandular parenchyma. The glands’ radiological and CT features defined their position relative to the right and left kidneys. The right suprarenal gland was with normal attenuation. The left suprarenal gland was located at a distance from the left kidney. The US features of the glands demonstrated variability in darkness and contrast, revealing specific histological features. The MRI peculiarities of the glands defined them as well visible findings

Some macrometric anatomical parameters of the adrenal glands in the New Zealand white rabbit

“…In our investigation, we used the published data (5,6) for the anatomical peculiarities and topography of the studied organs in the rabbit for better orientation. This study is a continuation of the previous study for the rabbit glands (6) and deepens the knowledge for these glands, because it is focused on the macrometric parameters.…”

“…The left gland is oval and situated laterally to the abdominal aorta. The right gland is closer to the right kidney, while the left gland is in a distance to the left kidney (5,6). The adrenal glands in the cat are situated cranially to the right and respectively the left kidney.…”

Effect of Nephrectomy on Some Haemato-Biochemical Parameters in Adult White Male New Zealand Rabbits Strain

“…The development of new surgical technologies and their translation from research to the clinical setting require appropriate experimental models [7]. In modern human medicine, the New Zealand white rabbit is an appropriate animal model for anatomical and histological studies because it is calm and tolerant of disorders better than other species [8]. Besides this, nephrectomy is most commonly performed on healthy rabbits for research purposes because it serves as a model for human renal damage and kidney transplantation [9], so a rabbit kidney was used for this study because several important parameters can be evaluated, where tissue morphology and composition can be studied qualitatively and quantitatively [10].…”

The role of resveratrol in hepatotoxicity caused by methotrexate

“…Rsv has been studied for a several decades in different therapeutic research areas and epidemiological studies have observed the relationship between consumption of Rsv and healthy (16,17). Laboratory animals are used in many experimental studies (18)(19)(20)(21). In numerous experimental studies reported that resveratrol possesses many bioactivities and has beneficial for healthy like antioxidant, anti-inflammatory, improving diseases and also has a hepatoprotective effect (22,23).…”