"Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Comment

Ogweno, Gordon

doi:10.1111/jth.15868

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Many studies of platelet function in trauma have referred to this phenomenon as -'platelet granule exhaustion' [32]' [31] in line with previous findings in other conditions [56][57][58] that share similarities with storage pool disorders [59]. However, this position lacks consistent support and has been refuted [60] since trauma platelets still retain response to P-selectin expression though with differences in agonists [14] indicating differences in signaling mechanisms rather than exhaustion. Moreover, there is overreliance of platelet aggregation studies which have been shown to be unreliable in storage pool disorders [61,62].…”

Section: Platelet Granule Exhaustionmentioning

confidence: 81%

Interplay between Platelet Dysfunction and Vascular Thrombosis in Traumatic Injury

Ogweno¹,

Murungi²

2023

Microcirculation - Updates in the Next Frontier of Vascular Disease

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Platelets halt bleeding accompanying traumatic injury by performing primary hemostasis to repair vascular leakage at injury sites. In trauma individuals, ex vivo platelet function tests often indicate impairment despite normal count. Moreover, incubation of platelets from normal non-traumatized individuals with plasma from trauma victims demonstrates impairment suggesting association with factors in circulation. Notably, not all trauma victims die from hemorrhage. Despite laboratory evidence of dysfunction, thrombotic vascular occlusions are persistent in trauma survivors as corroborated by postmortem findings from victims who die. The time course of platelet reactions post-traumatic injury, that is, the transition from states favoring bleeding to those that facilitate thrombosis is still unclear. Of the several terminologies describing platelet behavior with regards to injury, including hyporeactivity, anergy, exhaustion, and maladaptive states, few have focused on platelet-platelet interactions. It is increasingly becoming clear that platelet interaction with injured endothelium is a probable missing link in the mechanistic explanation of vascular thrombosis post-traumatic injury. This postulate is supported by evidence of increased adhesive protein, von Willebrand factor, and released from injured endothelium. In all, this potentially explains the suboptimal response to anticoagulants or antiplatelets post-trauma. This chapter will review current knowledge on platelet functions in relation to vascular thrombosis post-trauma, the time course, mechanistic hypothesis, and response to therapeutic interventions and clinical outcomes.

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Section: Platelet Granule Exhaustionmentioning

confidence: 81%

Interplay between Platelet Dysfunction and Vascular Thrombosis in Traumatic Injury

Ogweno¹,

Murungi²

2023

Microcirculation - Updates in the Next Frontier of Vascular Disease

View full text Add to dashboard Cite

show abstract

"Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Comment

Abstract: He read and gave useful suggestions and corrections for the manuscript.

Cited by 1 publication

References 15 publications

Interplay between Platelet Dysfunction and Vascular Thrombosis in Traumatic Injury

Interplay between Platelet Dysfunction and Vascular Thrombosis in Traumatic Injury

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