Important structural features of antimicrobial peptides towards specific activity: Trends in the development of efficient therapeutics

Fathi, Fariba; Alizadeh, Bahareh; Tabarzad, Mohammad Vahid; Tabarzad, Maryam

doi:10.1016/j.bioorg.2024.107524

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2024.107524

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Important structural features of antimicrobial peptides towards specific activity: Trends in the development of efficient therapeutics

Fariba Fathi,

Bahareh Alizadeh,

Mohammad Vahid Tabarzad

et al.

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2024

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Cited by 3 publications

References 59 publications

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Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides

Guo,

Farhan,

Gan

et al. 2024

Biotech & Bioengineering

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Antibacterial resistance has emerged as a significant global concern, necessitating the urgent development of new antibacterial drugs. Antimicrobial peptides (AMPs) are naturally occurring peptides found in various organisms. Coupled with a wide range of antibacterial activity, AMPs are less likely to develop drug resistance and can act as potential agents for treating bacterial infections. However, their characteristics, such as low activity, instability, and toxicity, hinder their clinical application. Consequently, researchers are inclined towards artificial design and optimization based on natural AMPs. This review discusses the research advancements in the field of artificial designing and optimization of various AMPs. Moreover, it highlights various strategies for designing such peptides, aiming to provide valuable insights for developing novel AMPs.

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Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides

Guo,

Farhan,

Gan

et al. 2024

Biotech & Bioengineering

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Propolis extract and Hermetia illucens larval proteins synergistically inhibit the growth of Aspergillus niger

Ding,

Zheng,

Zhu

et al. 2024

Food Bioscience

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Effects of the Tobacco Defensin NaD1 Against Susceptible and Resistant Strains of Candida albicans

Shevchenko,

Voropaev,

Bogdanov

et al. 2024

Pathogens

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Today, Сandida albicans is still the most common cause of both local and life-threatening systemic candidiasis. The spread of resistant fungal strains has resulted in an urgent need to search for new promising antimycotics. Here, we investigated the antifungal action of the tobacco defensin NaD1 against susceptible and resistant to azoles and echinocandins strains of C. albicans. We demonstrated that NaD1 was equally effective and fungicidal against all tested strains. The MIC and MFC values were 6.25 and 12.5 µM, respectively. We showed for the first time that NaD1 could act synergistically not only with caspofungin but also with human host defense antimicrobial peptides cathelicidin LL-37 and β-defensin-2 (HBD2) against susceptible and resistant fungal strains. Using flow cytometry, we demonstrated that NaD1 in combinations with LL-37 or HBD2 can reinforce each other by enhancing membrane disruption. Using the Caco-2 cell monolayer model, we demonstrated that NaD1 impaired the adhesion of С. albicans cells to the human epithelium. Moreover, NaD1 inhibited the formation of fungal biofilms in Sabouraud broth and less markedly in nutrient-rich RPMI-1640 medium, and enhanced the antibiofilm activity of caspofungin. Thus, we hypothesized that NaD1 might affect the development of candidiasis in vivo, including that caused by resistant fungal strains.

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Important structural features of antimicrobial peptides towards specific activity: Trends in the development of efficient therapeutics

Cited by 3 publications

References 59 publications

Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides

Advances in Artificially Designed Antibacterial Active Antimicrobial Peptides

Propolis extract and Hermetia illucens larval proteins synergistically inhibit the growth of Aspergillus niger

Effects of the Tobacco Defensin NaD1 Against Susceptible and Resistant Strains of Candida albicans

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