Biosensors are micro‐analytical devices usually coupled to a bio‐integrated transducer that emits signal to measure specific molecules as an analyte, either qualitatively or quantitatively for various downstream applications. Improved detection methods at quantum level in nanoscale became a reality due to the invention of integrated circuits involving nanoparticle devices and biolabels. Next level of discoveries leads to the identification of novel particulates to improve the specificity and sensitivity for single analyte detection. Although different kinds of biosensors show promise for multifaceted applications in science and technology, certain limitations do exist in terms of portability, selectivity and sensitivity as well as in multi‐analyte detection. Recent methodical advancements involving nanomaterials or nanoparticles/metals in combination with biomarkers or biolabels as sensors provide new insights to solve these limitations to prepare flawless detecting devices. These technical advances are evident in modern‐day sensors including hand‐held, smartphone‐based, wearable and flexible sensors developed for multifaceted applications. This concise review article describes the new technological trends in the development of biosensors integrated to nanoparticle devices and/or biolabels involving hi‐tech network system for better efficiency. Future perspectives on new technological developments for effective combination of several nanomaterials and biolabels with strategic engineering methodology were highlighted.