Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein

Baláž, Miroslav; Ukropcová, Barbara; Kurdiová, Tímea; Sůrová, Martina; Krumpolec, Patrik; Vaňuga, Peter; Gašperíková, Daniela; Klimeš, I; Payer, Juraj; Wolfrum, Christian; Ukropec, Jozef

doi:10.4161/21623945.2014.973772

Cited by 14 publications

(10 citation statements)

References 48 publications

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“…Zinc alpha-2-glycoprotein (ZAG), which is involved in lipid metabolism, was among the hub genes identified in this study 31 ; it is also reported to be significantly associated with obesity. 32 ZAG levels in serum are negatively correlated to body weight and body fat percentage. Balaž et al 32 discovered that the expression level of ZAG in adipose tissue is positively associated with insulin sensitivity of the whole body and adipose tissue but negatively correlated with the morphological size of adipocytes.…”

Section: Discussionmentioning

confidence: 98%

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Adults and Children With Diabetes and Dry Eye

Zou

Wang

Zhang

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose Diabetics are more prone to suffer from dry eye (DE). The ages of diabetes are decreasing, so ocular surface status in younger generations is worthy of attention. We used tandem mass tag (TMT)–labeled proteomics and weighted correlation network analysis (WGCNA) to identify differentially expressed proteins in the tear proteome of adults and children with diabetic DE. Methods Study subjects were divided into six groups of 10, including three groups each for adults and children. The adult groups included diabetics with DE (A), diabetics without DE (B), and normal controls (C); the corresponding groups of children were identified as (D), (E), and (F). DE tests were performed on all subjects. We extracted total proteins and labeled them with TMTs for analysis. WGCNA was used to recognize hub genes. Results Tear film function was poorer in patients with diabetic DE. In adults, 1922 proteins were identified, and WGCNA analysis revealed three hub genes related to diabetic DE. For children, 2709 proteins were identified, and WGCNA analysis identified one hub gene related to diabetic DE. Kyoto Encyclopedia of Genes and Genomes analysis found similarities among metabolic pathways involved in differential expression of proteins in adult and child tear samples. Conclusions The pathogenesis of diabetic DE was highly similar in adults and children. The differentially expressed tear proteins in type 2 diabetes of adults and children was associated with inflammation, immune factors, and lipid metabolism. Translational Relevance Our findings found high similarities in the pathogenesis of diabetic DE in adults and children.

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Section: Discussionmentioning

confidence: 98%

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Adults and Children With Diabetes and Dry Eye

Zou

Wang

Zhang

et al. 2020

Trans. Vis. Sci. Tech.

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“…The inverse associations of BMI at age 7 with glucose and glycoprotein, both of which are greater with higher BMI at age 60-64, may indicate that they were particularly responsive to greater gains in BMI between childhood and adulthood. These metabolites have been associated with adverse metabolic pathways including insulin resistance and advanced glycated end (AGE) products which are often activated in obesity (38,40).…”

Section: Discussionmentioning

confidence: 99%

Metabolomic correlates of central adiposity and earlier-life body mass index

Wulaningsih

Proitsi

Wong

et al. 2019

Journal of Lipid Research

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BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from early life. We investigated associations between different adiposity measures, BMI from childhood through adulthood, and metabolites quantified from serum using 1H NMR spectroscopy in 900 British men and women aged 60–64. We assessed BMI, waist-to-hip ratio (WHR), android-to-gynoid fat ratio (AGR), and BMI from childhood through adulthood. Linear regression with Bonferroni adjustment was performed to assess adiposity and metabolites. Of 233 metabolites, 168; 126; and 133 were associated with BMI, WHR, and AGR at age 60–64, respectively. Associations were strongest for HDL, particularly HDL particle size—e.g., there was 0.08 SD decrease in HDL diameter (95% CI: 0.07–0.10) with each unit increase in BMI. BMI-adjusted AGR or WHR were associated with 31 metabolites where there was no metabolome-wide association with BMI. We identified inverse associations between BMI at age 7 and glucose or glycoprotein at age 60–64 and relatively large LDL cholesteryl ester with postadolescent BMI gains. In summary, we identified metabolomic correlates of central adiposity and earlier-life BMI. These findings support opportunities to leverage metabolomics in early prevention of cardiovascular risk attributable to body fatness.

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“…A number of studies have shown that such an increase has no clinical significance [14, 15]. IGF-1 significantly increased but always remained within the normal range of concentrations.…”

Section: Discussionmentioning

confidence: 99%

Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device

Loche

Salerno

Garofalo

et al. 2016

J Endocrinol Invest

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PurposePoor adherence to recombinant human growth hormone (r-hGH) therapy is associated with reduced growth velocity in children with growth hormone deficiency (GHD). This twelve-month observational study was to assess adherence in r-hGH patients treated with the easypod™, an electronic, fully automated injection device designed to track the time, date and dose administered.MethodsNinety-seven prepubertal patients receiving r-hGH therapy were included in the study from ten Italian clinical sites and 88 completed the study. To avoid possible confounding effects, only GHD patients (79/88; 89.7 % of the overall study population) were considered in the final analysis. The primary endpoint—adherence to treatment—was calculated as the proportion of injections correctly administered during the observational period out of the expected total number of injections. The relevant information, tracked by the easypod™, was collected at months 6 (V1) and 12 (V2) after baseline (V0). At study termination, adherence data were partially available from 16 patients and fully available from 53 patients. As secondary endpoints, serum IGF-1 levels, fasting serum glucose and insulin levels and key anthropometric characteristics (height, waist circumference and BMI) were also determined. ResultsThe easypod™ data showed that 56.7 % of the patients were considered to be fully (≥92 %) adherent to their treatment throughout the period V0–V2. Treatment improved stature, significantly increased IGF-1 and produced a non-significant increase in blood glucose and insulin levels.ConclusionsThe injection-recording system and other characteristics of easypod™ could enhance the ability of physicians to monitor adherence to r-hGH treatment.

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Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein

Cited by 14 publications

References 48 publications

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Adults and Children With Diabetes and Dry Eye

Quantitative Proteomics and Weighted Correlation Network Analysis of Tear Samples in Adults and Children With Diabetes and Dry Eye

Metabolomic correlates of central adiposity and earlier-life body mass index

Adherence in children with growth hormone deficiency treated with r-hGH and the easypod™ device

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