Improved and Safe Transcorneal Delivery of Flurbiprofen by NLC and NLC-Based Hydrogels

González‐Mira, Elisabet; Nikolic, Sasha; Calpena, Ana Cristina; Egea, M.A.; Souto, Eliana B.; García, María L.

doi:10.1002/jps.22784

Cited by 65 publications

(22 citation statements)

References 47 publications

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“…This phenomenon could also be observed in cryoSEM images (Figure 2). Similar results were described by Gonzalez-Mira et al 36 …”

Section: Texture Analysissupporting

confidence: 92%

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Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

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Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration).

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“…This phenomenon could also be observed in cryoSEM images (Figure 2). Similar results were described by Gonzalez-Mira et al 36 …”

Section: Texture Analysissupporting

confidence: 92%

“…Similar results have been described elsewhere. 22,36 In contrast, a high variation in ZP values was observed, which could have been related to the negative charge of the carboxylic groups present on the gelling agent (PFC). Nonetheless, the values remain acceptable, since they are, in absolute value or modulus, higher than 30 mV.…”

mentioning

confidence: 97%

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

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show abstract

“…The medium was stirred at 100 rpm and maintained at 37°C ± 0.5°C. At 2,4,8,10,12,18,24,36, and 48 hours; a 1 mL dispersion sample was withdrawn and replaced with the same volume of fresh medium so that a constant volume submit your manuscript | www.dovepress.com…”

Section: In Vitro Drug-release Assaymentioning

confidence: 99%

“…11 NLCs loaded with poorly water-soluble drugs (eg, etoposide) can improve their oral bioavailability 12 and reduce the side effects of these drugs. 13 Previously, we showed that NLCs can improve the dissolution properties of tripterine and promote its intestinal absorption.…”

Section: Introductionmentioning

confidence: 99%

“…The delayed release process might be attributed to the drug lipophilicity, high hydrophobicity of the lipid matrix, and/or prevention of drug diffusion from the NLCs by the lipid matrix. 12 The slightly slower release of tripterine from the CT-NLCs than from the T-NLCs may be due to particle size; in particular, the increased size of the CT-NLC particles may have been associated with a smaller specific surface area of nanoparticles, which may have led to a decreased release rate. 33 The results of the MTT assay indicated that cytotoxicity was dose dependent over a range of drug concentrations.…”

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confidence: 99%

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Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Chen

Yuan²,

Zhou³

et al. 2012

IJN

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Purpose: To develop nanostructured-lipid carriers (NLCs) coated with cell-penetrating peptides (CPP) for improving the oral bioavailability of tripterine. Methods: We prepared CPP-coated tripterine-loaded NLCs (CT-NLCs) by using a solvent evaporation method, and determined their physical properties. In vitro drug release was determined by using a dialysis bag diffusion technique, and intestinal toxicity was evaluated by performing MTT assay using Caco-2 cells. In vivo absorption was studied in an in situ rat intestinal perfusion model, and oral bioavailability was examined in beagles. Results: The average particle size, zeta potential, and encapsulation efficiency of the optimized CT-NLCs were 126.7 ± 9.2 nm, 28.7 ± 3.4 mV, and 72.64% ± 1.37%, respectively. The CT-NLCs showed a controlled release profile in vitro and had significantly lower intestinal cytotoxicity than the tripterine solution (P , 0.05). The absorption levels of tripterine from the CT-NLCs in the rat duodenum and jejunum were markedly higher than with tripterine-loaded NLCs without the CPP coating (T-NLCs), and with tripterine solution. Pharmacokinetic study showed that the maximum concentration of the CT-NLCs was greater than that of the T-NLCs and tripterine suspension, and that the time to maximum concentration of the CT-NLCs as well as the T-NLCs, was longer than that of the tripterine suspension. The relative oral bioavailability of the CT-NLCs compared to that of tripterine suspension and T-NLCs were 484.75% and 149.91% respectively. Conclusion: The oral bioavailability of tripterine is dramatically increased by CT-NLCs. Therefore, CT-NLCs seem to be a promising carrier for oral delivery of tripterine.

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Nanoparticle Products for the Eye: Preformulation, Formulation, and Manufacturing Considerations

Souto

Espina

Cano

et al. 2021

Ophthalmic Product Development

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Improved and Safe Transcorneal Delivery of Flurbiprofen by NLC and NLC-Based Hydrogels

Cited by 65 publications

References 47 publications

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine

Nanoparticle Products for the Eye: Preformulation, Formulation, and Manufacturing Considerations

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