Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart

Abstract

There is no evidence from these results to support the involvement of adenosine to any major extent in preconditioning induced protection of postischaemic contractile function in the isolated rat heart.

Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning

“…Compared with IR group, in IPC group MDA in the liver tissue was decreased and every antioxidant enzyme was increased conspicuously, which reduced the injury to mitochondrial membrane lipid peroxidation by toxic oxygen radicals, protected the integrity of the structure and function of mitochondria, and prevented the apoptosis of liver parenchyma cells. Cave et al [27] reported that, in an isolated perfused heart model, compared with sudden reperfusion (remove artery snare occluder abruptly), controllable and slow reperfusion could decrease the occurrence of ventricular fibrillation. The postconditioning treatment in the present study was essentially comparable in some senses to those controlled and slow reoxygenation.…”

Mechanisms of Cardiac Preconditioning: Ten Years after the Discovery of Ischemic Preconditioning

“…dotoxin, the initial stimulus transmits a message to the cellular machinery that influences the cell's response Adenosine to a subsequent challenge. These stimuli result in the transient phosphorylation and dephosphorylation of inSeveral beneficial effects of adenosine on the ischemic myocardium have been proposed [7,23,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. tracellular enzymes and/or ion channels that are therapeutically accessible.…”

“…In most cells, physiologic re-cluding humans [7,9,12,31,44,57]. However, several investigators [30,43,51,58] have questioned the imsponses persist longer than it takes Ca 2/ concentrations to return to basal levels. Activation of cell surface portance of the adenosine signaling pathway in the protection of rat myocardium, due to the failed initial atreceptors often results in regular oscillations of intracellular Ca 2/ concentration ([Ca 2/ ] i ).…”

“…In fact, we mediated pathway that regulates/induces endogenous adaptive systems. Although these receptors are often [59] and others [43,58] have reported a failure of lowdose adenosine (10, 20, and 50 mM) to induce cardiac associated with their hemodynamic effects, they have also been implicated in the adaptive mechanisms of protection in the rat. Low-dose adenosine (20 mM) has been reported [45] to induce protection when adminis-hypertrophy and metabolic remodeling [30,64].…”

No Protection of the Porcine Kidney by Ischaemic Preconditioning

“…In contrast to rat kidneys, IP did not protect human embryonic kidney cells in vitro, whereas rabbit ventricular myocytes and differentiated CµC12 myotubes were protected by IP (Liu et al 1996). IPrelated mechanistic information obtained in rat hearts was frequently not transferable to other species (Cave et al 1993;Grover et al 1993). Therefore, this study investigated the influence of IP on postischaemic function and morphology in porcine kidneys.…”