Improved gene transfer efficiency of a DNA-lipid-apatite composite layer by controlling the layer molecular composition

Yazaki, Yushin; Oyane, Ayako; Tsurushima, Hideo; Araki, Hideki; Sogo, Yu; Ito, Atsuo; Yamazaki, Atsushi

doi:10.1016/j.colsurfb.2014.07.001

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…Recent studies have shown that this biomaterial exhibits excellent mechanical properties (Saber‐Samandari & Gross, ) as well as osteogenic potential (Chatterjee, Sun, Chow, Young, & Simon, ). ACP nanostructured compounds have excellent biocompatibility and bioactivity (Yazaki et al, ; Hoffman et al, ), being used as a substrate for bone formation (He et al, ; Syed‐Picard, Jayaraman, Lam, Beniash, & Sfeir, ).…”

Section: Introductionmentioning

confidence: 99%

Amorphous calcium phosphate (ACP) in tissue repair process

Allegrini

Silva

Tsujita

et al. 2018

Microscopy Res & Technique

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Synthetic biomaterials submitted to new structural technologies have become ideal for the recovery of traumatized bone tissues and some bone substitutes such as bioactive glass, β-Tricalcium phosphate (β-TCP) and amorphous calcium phosphate (ACP) are being used in areas of tissue defects. For this study, ACP was produced in the form of fibers and then submitted to cytotoxicity testing. A sample of ACP was inserted into the mandibular region of a patient with a lost implant so after removal and curettage, the remaining bone site was filled with the ACP biomaterial. Preliminary cytotoxicity test was negative. After 15 weeks of healing, a titanium implant was inserted at the site. Clinical and radiographic follow-up was conducted for 12 months and sequential radiographic analyses revealed tissue formation resembling spongy bone. Images under immunohistochemistry demonstrated efficient deposition and osteoconduction of the newly deposited tissue. Residual portion of the CaO:P O outer layers served as a substrate for osteoid matrix deposition, aiding growth, and the results of fiber absorption favored maturation of the new bone tissue.

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