Improved Hemodynamics With Temporary Porto-Caval Shunt in Orthotopic Liver Transplantation

Hesse, Uwe; Berrevoet, Frederik; Troisi, Roberto; Mortier, Éric; Pattyn, Piet; Ongenae, M; Decruyenaere, Johan; Hemptinne, Bernard de

doi:10.1097/00007890-199905150-00397

Cited by 2 publications

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“…Results from the 8 included articles are summarized in Tables 1 and 2, including a total of 2073 patients. 1,3,[8][9][10][11][12][13] The indication for transplantation was given for 647 recipients. The majority of patients had chronic liver disease (95.51%), with the remainder (4.49%) being transplanted for acute liver failure.…”

Section: Resultsmentioning

confidence: 99%

“…The time course of the liver disease was not specified in 1426 patients. 12,13 Operative data were available for 712 patients and are summarized in Table 1. The duration of the operation in patients undergoing TPCS ranged from 330 Ϯ 63 to 465 Ϯ 86 minutes.…”

Section: Resultsmentioning

confidence: 99%

“…10 The intraoperative blood product transfusion requirement was described in 6 articles. 1,3,8,10,13,14 The number of red blood cell units transfused into patients with a TPCS ranged from 1.1 Ϯ 2.3 to 98.4 Ϯ4.3 units. A comparison of patients with a TPCS and patients without one was reported in 3 articles.…”

Section: Resultsmentioning

confidence: 99%

“…10,13,14 Two of 3 studies found that a TPCS was associated with less red blood cell requirement. 13,14 The amount of fresh frozen plasma transfused into patients with a TPCS ranged from 1.4 Ϯ2.7 to 19 Ϯ14.7 units. Two of 3 studies found that TPCS was associated with less fresh frozen plasma transfusion.…”

Section: Resultsmentioning

confidence: 99%

“…Two of 3 studies found that TPCS was associated with less fresh frozen plasma transfusion. 13,14 Platelet transfusion was described in 3 studies and ranged from 5 to 17 units. 8,10,14 One of 2 studies found that TPCS was associated with less platelet transfusion.…”

Section: Resultsmentioning

confidence: 99%

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Temporary portocaval shunt in orthotopic liver transplantation: Need for a standardized approach?

2008

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Maintenance of portal and systemic venous return during the anhepatic phase of liver transplantation (LT) improves hemodynamic stability. With the piggyback technique, caval return is maintained; however, temporary clamping of the portal vein is still necessary. The use of a temporary portocaval shunt (TPCS) has been proposed to minimize the effect of portal venous interruption. The aim of this study was to perform a systematic review of the literature to determine whether there is evidence to support the routine use of a TPCS in LT. An electronic search of the literature from 1963 to 2007 was performed. A total of 4386 articles were identified, of which 8 met all the criteria and were included in the study. Because of the variability in reporting and the small number of studies, statistical comparison was not possible; however, a trend toward a shorter operative time, less blood product transfusion, and maintenance of higher mean arterial pressures during portal vein clamping was seen in patients with a TPCS. In conclusion, the available evidence, albeit scarce, supports the use of a TPCS in patients undergoing LT. A prospective randomized study of patients most likely to benefit from a TPCS is necessary to substantiate these findings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Temporary portocaval shunt in orthotopic liver transplantation: Need for a standardized approach?

2008

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Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation

Tang

Chuang

et al. 2011

Biopolymers

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GSK3β plays an important role in many physiological functions; dysregulated GSK3β is involved in human diseases such as diabetes, cancer, and Alzheimer's disease. This study uses MD simulations to determine the interaction between GSK3β and a peptide derived from GSKIP, a novel GSK3β interacting protein. Results show that GSKIPtide is inlaid in a binding pocket consisting of an α-helix and an extended loop near the carboxy-terminal end. This binding pocket is hydrophobic, and is responsible for the protein-protein interaction of two other GSK3β interacting proteins: FRAT and Axin. The GSKIPtide binding mode is closer to that of AxinGID (in the Axin-GSK3-interacting domain). The single-point mutations of V267G and Y288F in GSK3β differentiate the binding modes between GSK3 and GSKIPtide, AxinGID, and FRATide. The V2677G mutation of GSK3β reduces the GSKIPtide binding affinity by 70% and abolishes the binding affinity with AxinGID, but has no effect on FRATide. However, GSK3β Y288F completely abolishes the FRATide binding without affecting GSKIPtide or AxinGID binding. An analysis of the GSK3β-GSKIPtide complex structure and the X-ray crystal structures of GSK3β-FRATide and GSK3β-AxinGID complexes suggests that the hydroxyl group of Y288 is crucial to maintaining a hydrogen bond network in GSK3β-FRATide. The hydrophobic side chain of V267 maintains the integrity of helix-helix ridge-groove hydrophobic interaction for GSK3β-GSKIPtide and GSK3β-AxinGID. This study simulates these two mutant systems to provide atomic-level evidence of the aforementioned experimental results and validate the wild-type complex structure prediction.

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Improved Hemodynamics With Temporary Porto-Caval Shunt in Orthotopic Liver Transplantation

Cited by 2 publications

References 0 publications

Temporary portocaval shunt in orthotopic liver transplantation: Need for a standardized approach?

Temporary portocaval shunt in orthotopic liver transplantation: Need for a standardized approach?

Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation

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