Improved hemostatic effects by Fe3+ modified biomimetic PLLA cotton-like mat via sodium alginate grafted with dopamine

Abstract

The development of an excellent, bioabsorbable hemostatic material for deep wound remains a challenge. In this work, a biodegradable cotton-like biomimetic fibrous mat of poly ( l -lactic acid) (PLLA) was made by melt spinning. Subsequently, SD composite was prepared by cross-linking sodium alginate (SA) with dopamine (DA). It was immobilized on the fibre surface, which inspired by mussel byssus. Finally, Fe 3+ was loaded onto the 0.5SD/PLLA composite by chelation with the carboxyl of alginate and phenolic hydroxy of dopamine. The haemostasis experiment found that the hemostatic time 47 s in vitro. However, the bleeding volume was 0.097 g and hemostatic time was 23 s when 20Fe 3+ -0.5SD/PLLA was applied in the haemostasis of the rat liver. As a result of its robust hydrophilicity and bouffant cotton-like structure, it could absorb a large water from blood, which could concentrate the component of blood and reduce the clotting time. Furthermore, the addition of Fe 3+ in the 0.5SD/PLLA had a significant effect on improve hemostatic property. It also displayed excellent antibacterial property for Escherichia coli and Staphylococcus aureus . Notably, it possesses superior hemocompatibility, cytocompatibility and histocompatibility. Hence, 20Fe 3+ -0.5SD/PLLA has high potential application in haemostasis for clinical settings due to its outstanding properties.

Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction

“…First, the P-CS demonstrated a sharp increase in hydrophilicity, which is an essential factor that contributes to the hemostatic property of a biomaterial. Previous studies improved the hydrophilicity of a material by introducing hydrophilic groups onto the material [ 33 ]. The phosphate group is a hydrophilic group [ 34 ].…”

Application of Alginate-Based Hydrogels in Hemostasis

“…It is a biomaterial suitable for treating large-scale and irregular wounds. Furthermore, sodium alginate can also be used as a hydrophilic coating to enhance the hemostatic ability of composite materials [ 97 ].…”

Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive

“…Besides, it is rather expensive and may lead to a risk of blood-borne disease or virus infections ( Du et al, 2020 ; Gao et al, 2020 ). In comparison with fibrin glue, cyanoacrylates have much stronger adhesion capacity, but the excessive heat and the cytotoxic byproducts produced in the fast polymerization process during bonding are a major concern ( Lv et al, 2021 ). Additionally, their poor elasticity cannot accommodate the movement of soft tissues under a highly dynamic physiological environment ( Li et al, 2020 ; Zhao et al, 2021 ).…”