Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants

Raghuvanshi, Rajeev Singh; Katare, Yogesh K.; Lalwani, Komal; Ali, Mushir; Singh, Om; Panda, Amulya K.

doi:10.1016/s0378-5173(02)00342-3

Cited by 125 publications

(60 citation statements)

References 31 publications

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“…Many in vivo studies have been evaluated the antigen release and the amount of induced immunity by PLGA polymers with various molecular weights and L/G ratios. 26,36 For example, humoral response against HBsAg encapsulated in PLGA MSs with different L/G ratios (PLGA 50:50, 75:25, a mixture of PLGA 50:50 and 75:25, as well as PLGA 50:50-COOH) was investigated as a single dose vaccination. 36 It was clearly demonstrated that the HBsAg release from HBsAg-PLGA MSs was related to the surface morphology of the MSs, polymer composition (L/G ratio), and MW of the polymer (viscosity).…”

Section: Polymer Related Factorsmentioning

confidence: 99%

“…The PLGA 50:50-COOH MSs released HBsAg faster than the PLGA 50:50 and PLGA 75:25 MSs, respectively. 26 The glass transition temperature also relies on the composition and MW of the PLGA polymer. It has been shown that a decline in lactide quantity and MW is associated with a decrease in the degree of crystalinity of PLGA polymer.…”

Section: Polymer Related Factorsmentioning

confidence: 99%

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Peptide/protein vaccine delivery system based on PLGA particles

Allahyari

Mohit

2015

Human Vaccines & Immunotherapeutics

184

118

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Due to the excellent safety profile of poly (D,L-lactide-co-glycolide) (PLGA) particles in human, and their biodegradability, many studies have focused on the application of PLGA particles as a controlled-release vaccine delivery system. Antigenic proteins/peptides can be encapsulated into or adsorbed to the surface of PLGA particles. The gradual release of loaded antigens from PLGA particles is necessary for the induction of efficient immunity. Various factors can influence protein release rates from PLGA particles, which can be defined intrinsic features of the polymer, particle characteristics as well as protein and environmental related factors. The use of PLGA particles encapsulating antigens of different diseases such as hepatitis B, tuberculosis, chlamydia, malaria, leishmania, toxoplasma and allergy antigens will be described herein. The co-delivery of antigens and immunostimulants (IS) with PLGA particles can prevent the systemic adverse effects of immunopotentiators and activate both dendritic cells (DCs) and natural killer (NKs) cells, consequently enhancing the therapeutic efficacy of antigen-loaded PLGA particles. We will review co-delivery of different TLR ligands with antigens in various models, highlighting the specific strengths and weaknesses of the system. Strategies to enhance the immunotherapeutic effect of DCbased vaccine using PLGA particles can be designed to target DCs by functionalized PLGA particle encapsulating siRNAs of suppressive gene, and disease specific antigens. Finally, specific examples of cellular targeting where decorating the surface of PLGA particles target orally administrated vaccine to Mcells will be highlighted.

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Section: Polymer Related Factorsmentioning

confidence: 99%

Section: Polymer Related Factorsmentioning

confidence: 99%

Peptide/protein vaccine delivery system based on PLGA particles

Allahyari

Mohit

2015

Human Vaccines & Immunotherapeutics

184

118

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“…In solvent evaporation method, both the polymer and drug molecules are dissolved in volatile organic solvent and are sonicated [9]. The salting out method is based upon the principle of separation of water miscible solvents from the aqueous solution by adding salts like magnesium chloride and calcium chloride.…”

Section: Nanoencapsulation: Biodegradable Polymers and Methodsmentioning

confidence: 99%

Nanotechnology: A Spark to the Use of Plant Origin Bioactive Compounds in Therapeutics

Yadav¹

2015

Single Cell Biol

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“…[102] It has been reported that nanoencapsulation of drugs (nano-medicines) increases their efficacy, specificity, tolerability and therapeutic index [122][123][124]. These nano-formulations are reported to be superior to traditional medicine with respect to controlled release, targeted delivery and therapeutic impact.…”

Section: -Phase Inversion Temperaturementioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants

Cited by 125 publications

References 31 publications

Peptide/protein vaccine delivery system based on PLGA particles

Peptide/protein vaccine delivery system based on PLGA particles

Nanotechnology: A Spark to the Use of Plant Origin Bioactive Compounds in Therapeutics

Nanocarrier Systems for Transdermal Drug Delivery

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