Improved immune responses to a bivalent vaccine of Newcastle disease and avian influenza in chickens by ginseng stem-leaf saponins

Yu, Jingquan; Shi, Fushan; Hu, Songhua

doi:10.1016/j.vetimm.2015.07.017

Cited by 43 publications

(24 citation statements)

References 43 publications

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“…Wang et al (2015) menunjukkan saponin berkhasiat sebagai antioksidan dan hepatoprotektor. Beberapa penelitian lain menunjukkan bahwa saponin berkhasiat juga sebagai antikanker (Man et al, 2015;Yuan et al, 2013), meningkatkan imunitas pada unggas (Yu et al, 2015a), antitumor (Yu et al, 2015b), dan imunomodulator (Nalbantsoy et al, 2012). Metabolit sekunder triterpenoid melalui kajian farmakologi telah diketahui berkhasiat diantaranya sebagai antiaterosklerosis , antikanker (Farimani et al, 2015), hepatoprotektor (Gan et al, 2015), dan antioksidan (Qiao et al, 2015).…”

Section: Hasil Dan Pembahasanunclassified

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Nurcholis

Khumaida²,

Syukur³

et al. 2017

J Agron Indonesia

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ABSTRACT Curcuma aeruginosa Roxb., popularly known as “temu ireng”, is considered as a potential source of medicinal plant for pharmacological activities. However, varieties of C. aeruginosa are still limited in Indonesia so it needs more accessions for improvement and development of new varieties. Rhizome colors, phytochemical contents and extract yield from 20 promising lines of C. aeruginosa were investigated by qualitative method for rhizome colors and phytochemical contents, and maceration method using 70% ethanol for yield extract. Similarity analysis was used for cluster analysis based on rhizome colors, phytochemical contents and yield extract. Blue was the color characterization of rhizome C. aeruginosa. The extract yield for 20 promising lines of C. aeruginosa varied from 7.92 to 19.71%, with KN and BH promising lines having the lowest and highest value, respectively. All promising lines of C. aeruginosa contain saponin and triterpenoid. Based on similarity analysis, all promising lines could be divided into 3 clusters. Cluster I consisted of 14 promising lines i.e. WG, SH, KA, GD, BH, KP, NW, PW, MB, PR, PT, KN, MD, and PK. Cluster II consisted of 4 promising lines i.e. LC, CB, KL, and GK. Cluster III consisted of 2 promising lines i.e. KD and SG. Keywords: promising lines, saponin, triterpenoid

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Section: Hasil Dan Pembahasanunclassified

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Nurcholis

Khumaida²,

Syukur³

et al. 2017

J Agron Indonesia

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“…Over the last few years, outbreaks of pseudorabies have been reported on farms that widely used attenuated live vaccine (Bartha‐K61), indicating that the vaccine does not provide effective protection against PrV infection in various regions of China . Medicinal extracts from various traditional herbs have been extensively used as adjuvants with the aim of improving the protective immunity conferred by vaccines against viral diseases . In the present study, we demonstrated that GSLS and Se (in the form of sodium selenite) have an adjuvant effect and that combined administration of GSLS and Se stimulates significantly enhanced immune responses than does GSLS or Se used alone.…”

Section: Discussionmentioning

confidence: 65%

“…injection of inactivated ND and AI vaccines, and oral administration of attenuated live infectious bursal disease vaccine (IBD) . Yu et al found that oral administration of GSLS significantly improved the immune responses of immune‐suppressed chickens to a bivalent live vaccine of ND and AI . Li et al reported that oral administration of GSLS to mice significantly increased the immune response to sc injection of FMD vaccine .…”

Section: Discussionmentioning

confidence: 99%

“…In mice, immune responses stimulated by foot and mouth disease (FMD) vaccine are reportedly significantly enhanced by oral gavage with GSLS . According to the findings of Yu et al, GSLS given orally to immunosuppressed chickens before immunization restores splenocyte proliferation, increases the number of intestinal immune cells and boosts HI antibody titers to a bivalent vaccine against Newcastle disease (ND) and avian influenza (AI). When supplemented with rapeseed oil, an oil adjuvant or oil‐emulsified FMD vaccine, GSLS reportedly shows a synergistic adjuvant effect .…”

Section: Introductionmentioning

confidence: 99%

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Ginseng stem‐leaf saponins in combination with selenium enhance immune responses to an attenuated pseudorabies virus vaccine

Maqbool

Wang

Cui

et al. 2019

Microbiology and Immunology

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Pseudorabies, a herpesvirus infection, is mainly controlled by using attenuated live vaccines. In this study, the effect of ginseng stem and leaf saponins (GSLS) in combination with selenium (Se; in the form of sodium selenite) on vaccination against attenuated pseudorabies virus (aPrV) was evaluated. It was found that GSLS and Se have an adjuvant effect and that a combination of GSLS and Se stimulates significantly enhanced immune responses than does GSLS or Se alone. Following oral administration of GSLS, mice immunized with an attenuated PrV vaccine diluted in Se‐containing physiological saline solution (PSS) provoked a significantly stronger gB‐specific serum antibodies response (IgG, IgG1 and IgG2a), enhanced lymphocyte proliferation and cytolytic activity of NK cells, along with higher production of cytokines (IFN‐γ, IL‐12, IL‐5 and IL‐10) by splenocytes. Notably, the combination of GSLS and Se conferred a much higher resistance to fPrV challenge after immunization of the mice with aPrV vaccine. This study offers convincing experimental evidence that an injection of Se with oral GSLS is a promising adjuvant combination that improves the efficacy of vaccination against PrV and deserves further study regarding improvement of responses to other animal vaccines.

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“…Results also indicated that the CVCVA5 adjuvant is capable of increasing the efficacy of the vaccine with four antigens. The previous studies (Gough et al, 1977;Li et al, 2012;Yu et al, 2015) also showed the adjuvants can improve the efficacy of multivalent vaccines.…”

Section: Discussionmentioning

confidence: 95%

Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickens

Feng

et al. 2017

Front. Microbiol.

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We previously described that immunopotentiators, CVCVA5, increased the efficacy of H5 and H9 subtype avian influenza vaccines in chickens, ducks, and geese. In this study, we further investigated the effects of the CVCVA5 for improving the efficacy of other univalent or multivalent inactivated vaccines. The immune response administrated with half-dose of monovalent vaccine plus CVCVA5 were higher than those of one dose of monovalent vaccine without immunopotentiators as measured by levels of antibodies from serum, tears and bronchoalveolar lavage fluids, and cytokines of IFNγ and IL-4 from serum. Vaccines included the univalent vaccine of Newcastle Disease virus (ND), Egg Drop Syndrome virus (EDS), Infectious Bronchitis virus (IB), and Infectious Bursal Disease virus (IBD). The CVCVA5 also improved the immune response of both ND and IBD vaccines with less dosage. The sterile protective immunity was monitored with one- or a half-dose of adjuvanted ND vaccine or one dose of adjuvanted IBD vaccine, respectively. The improved immune efficacy was observed in a half-dose of adjuvanted bivalent vaccines compared to one dose of vaccines without CVCVA5 as measured by the antibody levels, including bivalent vaccine of ND-H9, ND-IB, and ND-IBD. The CVCVA5 also boosted the immune efficacy of the tetravalent vaccine (ND-IB-EDS-H9). A half-dose of adjuvanted commercial vaccine or 75% antigen-sparing adjuvanted vaccine elicited similar antibody levels to those of one dose non-adjuvanted commercial vaccines. The CVCVA5 improved the effect of a booster vaccination as measured by the antibody levels against H5 or H9 virus antigens, in which chickens primed with the adjuvanted ND-IB vaccines given a booster with H5–H9 bivalent vaccines without CVCVA5 using 5-day intervals. The inflammatory response may contribute to these additional effects by increasing the levels of IFNγ and IL-4 after the injection of the adjuvanted ND-IB vaccines. Results indicated that the CVCVA5 improved the serum and mucosal antibody levels, cytokine levels of the chickens given the univalent vaccine, and also improved serum antibody titers in bivalent and tetravalent vaccines. This has a potential as an improve vaccine.

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Improved immune responses to a bivalent vaccine of Newcastle disease and avian influenza in chickens by ginseng stem-leaf saponins

Cited by 43 publications

References 43 publications

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Ginseng stem‐leaf saponins in combination with selenium enhance immune responses to an attenuated pseudorabies virus vaccine

Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickens

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