Improved Lactose Powder Properties by In-situ Coating with Additives during Spray Drying

Brech, Michael; Pearce, David; Bagga, Payel; Nijdam, J. J.

doi:10.12720/jomb.2.3.207-213

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…However, beyond a certain level of a highly compressible plastic material, a slight decrease in hardness can occur (23). Co-processed excipients like spray dried lactose coated with sodium caseinate or gelatin was shown to have excellent compaction properties (24,25). These coating additives accumulate on the surface of droplets during the spray-drying process and increase the bulk density, flowability and reduce the wetting time of powders.…”

Section: Fillers For Asdsmentioning

confidence: 99%

Downstream processing of amorphous solid dispersions into tablets

Parupathi¹,

Dhoppalapudi²

2023

GSC Biol. Pharm. Sci.

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Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor drug loading associated with poor drug-polymer miscibility is a major challenge in the downstream processing of ASDs. While many downstream techniques are available for converting ASDs into final dosage forms, oral solids remain the most commercially viable. The type of excipients used in the conversion of ASDs into tablets are very similar to the excipients used in conventional tablets. For example, the binders used in conventional tablets are widely used as polymeric carriers in case of ASDs. The physical properties of ASDs manufactured using spray drying or hot melt extrusion pose major challenge in converting ASDs into oral tablets. The current review focuses on various challenges associated with converting ASDs into tablets and provide a comprehensive review on various excipients used in manufacturing tablets using ASDs.

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Section: Fillers For Asdsmentioning

confidence: 99%

Downstream processing of amorphous solid dispersions into tablets

Parupathi¹,

Dhoppalapudi²

2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

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Powdered plant beverages obtained by spray-drying without carrier addition-physicochemical and chemometric studies

Samborska,

Budziak-Wieczorek,

Matwijczuk

et al. 2024

Sci Rep

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Plant-based beverages (PBs) are currently gaining interest among consumers who are seeking alternative sustainable options to traditional dairy drinks. The study aimed to obtain powdered plant beverages without the addition of carriers by spray drying method to implement them in the future as an alternative to the liquid form of dairy drinks. Some of the most well-known commercial beverages sources like soy, almond, rice and oat were analyzed in this work. The effect of different treatments (concentration, addition of oat fiber) and two approaches od spray drying (conventional high temperature spray drying—SD, and dehumidified air spray drying at low temperature—DASD) were presented. Moreover, moisture content, water activity, particle morphology and size of obtained powders were analyzed. It was possible to obtain PBs without the addition of carriers, although the drying yield of four basic beverages was low (16.1–37.4%). The treatments and change in spray drying approach enhanced the drying yield, especially for the concentrated beverage dried using DASD (59.2%). Additionally, Fourier Transform Infrared (FTIR) spectroscopy was applied to evaluate the differences in chemical composition of powdered PBs. FTIR analysis revealed differences in the range of the absorption frequency of amide I, amide II (1700–1500 cm−1) and carbohydrate region (1200–900 cm−1). Principal component analysis (PCA) was carried out to study the relationship between spray dried plant beverages samples based on the fingerprint region of FTIR spectra, as well as the physical characteristics. Additionally, hierarchical cluster analysis (HCA) was employed to explore the clustering of the powders.

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