Improved method for cannula fixation for long-term intracerebral brain infusion

Sike, Ádám; Wengenroth, Jonas; Upīte, Jolanta; Brüning, Thomas; Eiriz, Ivan; Sántha, Petra; Biverstål, Henrik; Jansone, Baiba; Haugen, Håvard Jostein; Krohn, Markus; Pahnke, Jens

doi:10.1016/j.jneumeth.2017.07.026

Cited by 10 publications

(13 citation statements)

References 14 publications

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“…Similarly, the fixation of cannulas which must remain in place for longer time periods, e.g. in intracerebral brain infusion in which the curved skull shape makes it difficult to fix cannulas properly (Sike et al ., 2017) might be possible.…”

Section: Potential Applications Of Tick Cementmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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The majority of ticks in the family Ixodidae secrete a substance anchoring their mouthparts to the host skin. This substance is termed cement. It has adhesive properties and seals the lesion during feeding. The particular chemical composition and the curing process of the cement are unclear. This review summarizes the literature, starting with a historical overview, briefly introducing the different hypotheses on the origin of the adhesive and how the tick salivary glands have been identified as its source. Details on the sequence of cement deposition, the curing process and detachment are provided. Other possible functions of the cement, such as protection from the host immune system and antimicrobial properties, are presented. Histochemical and ultrastructural data of the intracellular granules in the salivary gland cells, as well as the secreted cement, suggest that proteins constitute the main material, with biochemical data revealing glycine to be the dominant amino acid. Applied methods and their restrictions are discussed. Tick cement is compared with adhesives of other animals such as barnacles, mussels and sea urchins. Finally, we address the potential of tick cement for the field of biomaterial research and in particular for medical applications in future.

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Section: Potential Applications Of Tick Cementmentioning

confidence: 99%

Tick attachment cement – reviewing the mysteries of a biological skin plug system

et al. 2017

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“…Sutures, staples, screws, and plates could often be replaced by the use of adhesives [74], sutures through small incisions are challenging in minimally invasive procedures (laparoscopic, endoscopic, robotic) [75,76], and gluing intravenous catheters to the skin could prevent phlebitis-inducing slippage and/or bacterial invasion [77,78]. Fixation of longer-duration intracerebral cannulae to the curved skull could also be improved in this manner [79].…”

Section: Long-term Attachment In the Skinmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

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Summary Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick‐derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick‐host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.

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“…Nähte, Klammern, Schrauben und Platten könnten oft durch Kleber ersetzt werden [74], bei minimalinvasiven Eingriffen (laparoskopisch, endoskopisch, robotergestützt) sind Nähte durch kleine Schnitte schwierig [75,76] und das Verkleben intravenöser Katheter auf der Haut könnte Phlebitis-induzierendes Rutschen und/oder Bakterieninvasion verhindern [77,78]. Auch die Fixierung länger verweilender intrazerebraler Kanülen am gewölbten Schädel könnte auf diese Weise verbessert werden [79].…”

Section: Langfristige Verankerung In Der Hautunclassified

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

Schön

2022

J Deutsche Derma Gesell

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Abbildung 1 Lebenszyklus des Gemeinen Holzbocks (Ixodes ricinus). Vollgesogenes Weibchen von dorsal (a). Vollgesogenes Weibchen von ventral (b). Reifer Samen des Wunderbaumes (Ricinus communis) zum Vergleich (c). Das vollgesogene Weibchen lässt sich von seinem letzten Wirt abfallen und legt in der Streuschicht am Boden zwischen 1000 und 2000 Eier, aus denen circa 0,5 mm große Larven schlüpfen (d). Diese lauern in niedriger Vegetation auf den ersten Wirt, meist kleinere Tiere. Die Larven häuten sich zu achtbeinigen, etwa 1 mm langen Nymphen, die den zweiten Wirt befallen. Nach dem Saugakt erfolgt die zweite Häutung zur erwachsenen Zecke ebenfalls in der Streuschicht am Boden. Weibchen und Männchen kopulieren schon in der Vegetation oder auf dem letzten Wirt.

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Improved method for cannula fixation for long-term intracerebral brain infusion

Cited by 10 publications

References 14 publications

Tick attachment cement – reviewing the mysteries of a biological skin plug system

Tick attachment cement – reviewing the mysteries of a biological skin plug system

The tick and I: Parasite‐host interactions between ticks and humans

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

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