Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial

Li, Fēi; Wu, Steven S.; Berseth, Carol Lynn; Harris, Cheryl L.; Richards, J. D.; Wampler, Jennifer L.; Zhuang, Weihong; Cleghorn, Geoffrey J.; Rudolph, Colin D.; Liu, Bryan; Shaddy, D. Jill; Colombo, John

doi:10.1016/j.jpeds.2019.08.030

Cited by 107 publications

(98 citation statements)

References 37 publications

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“…The latest papers that have an in-depth study and large number of subjects are those from Li, X. et al [9] and Li, F. et al [163]. The first study evaluated the effects on growth and infectious outcomes of IF supplemented with either MFGM or a probiotic (L. paracasei ssp.…”

Section: Mfgm Formula Group Did Notmentioning

confidence: 99%

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Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

et al. 2020

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Research on milk fat globule membrane (MFGM) is gaining traction. The interest is two-fold; on the one hand, it is a unique trilayer structure with specific secretory function. On the other hand, it is the basis for ingredients with the presence of phospho- and sphingolipids and glycoproteins, which are being used as food ingredients with valuable functionality, in particular, for use as a supplement in infant nutrition. This last application is at the center of this Review, which aims to contribute to understanding MFGM’s function in the proper development of immunity, cognition, and intestinal trophism, in addition to other potential effects such as prevention of diseases including cardiovascular disease, impaired bone turnover and inflammation, skin conditions, and infections as well as age-associated cognitive decline and muscle loss. The phospholipid composition of MFGM from bovine milk is quite like human milk and, although there are some differences due to dairy processing, these do not result in a chemical change. The MFGM ingredients, as used to improve the formulation in different clinical studies, have indeed increased the presence of phospholipids, sphingolipids, glycolipids, and glycoproteins with the resulting benefits of different outcomes (especially immune and cognitive outcomes) with no reported adverse effects. Nevertheless, the precise mechanism(s) of action of MFGM remain to be elucidated and further basic investigation is warranted.

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Section: Mfgm Formula Group Did Notmentioning

confidence: 99%

“…A separate study was designed to evaluate the growth, health, and cognitive effects of formula containing both MFGM and lactoferrin (Lf) [163]. Healthy term infants were fed through 12 months with either routine control formula (n = 208) or a formula containing MFGM-10 at 5 g/L + lactoferrin 0.6 g/L (n = 198).…”

Section: Mfgm Formula Group Did Notmentioning

confidence: 99%

Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

et al. 2020

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“…While researchers are still making efforts to understand the functionalities of MFGM, there are already commercialized products supplementing MFGMs from bovine milk cream. The effectiveness of supplementation of MFGM in formula has been demonstrated in several independent cellular and animal studies, and clinical trials [25][26][27][28]. In Bovine milk based infant formulas have attempted to closely mimic the lipid composition of naturally originated breast milk.…”

Section: Breast Milk Fat Globulesmentioning

confidence: 99%

Breast Milk Lipids and Fatty Acids in Regulating Neonatal Intestinal Development and Protecting against Intestinal Injury

et al. 2020

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Human breast milk is the optimal source of nutrition for infant growth and development. Breast milk fats and their downstream derivatives of fatty acids and fatty acid-derived terminal mediators not only provide an energy source but also are important regulators of development, immune function, and metabolism. The composition of the lipids and fatty acids determines the nutritional and physicochemical properties of human milk fat. Essential fatty acids, including long-chain polyunsaturated fatty acids (LCPUFAs) and specialized pro-resolving mediators, are critical for growth, organogenesis, and regulation of inflammation. Combined data including in vitro, in vivo, and human cohort studies support the beneficial effects of human breast milk in intestinal development and in reducing the risk of intestinal injury. Human milk has been shown to reduce the occurrence of necrotizing enterocolitis (NEC), a common gastrointestinal disease in preterm infants. Preterm infants fed human breast milk are less likely to develop NEC compared to preterm infants receiving infant formula. Intestinal development and its physiological functions are highly adaptive to changes in nutritional status influencing the susceptibility towards intestinal injury in response to pathological challenges. In this review, we focus on lipids and fatty acids present in breast milk and their impact on neonatal gut development and the risk of disease.

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“…In addition, MFGM formula-fed infants upregulated their ingested volumes when the energy density of formula was reduced from 66 to 60 kcal/100 mL. In a randomised controlled trial two groups of healthy term infants received bovine milk-based infant formula and the same supplemented with MFGM and lactoferrin, respectively, for 1 year (Li et al 2019a). Intake of supplemented formula accelerated the neurodevelopmental profile of infants and improved their language subcategories.…”

Section: Human Studiesmentioning

confidence: 99%

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

El-Salam

El-Shibiny

2020

Int J of Dairy Tech

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Milk fat globule membrane (MFGM) is a minor milk constituent composed of a large number of polar lipid (PL) classes and proteins organised in a tri-layer structure. The MFGM PLs and proteins have a wide range of nutritional and health benefits. Animal and human studies have shown that consumption of MFGM preparations has beneficial effects on brain development and function and physical performance, particularly in the elderly. MFGM also improves intestinal health and skin condition, combats hypercholesterolaemia, obesity and inflammation. The present article updates the information about MFGM; particularly its nutritional and health benefits.

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Improved Neurodevelopmental Outcomes Associated with Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula: A Randomized, Controlled Trial

Cited by 107 publications

References 37 publications

Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

Sources, Production, and Clinical Treatments of Milk Fat Globule Membrane for Infant Nutrition and Well-Being

Breast Milk Lipids and Fatty Acids in Regulating Neonatal Intestinal Development and Protecting against Intestinal Injury

Milk fat globule membrane: An overview with particular emphasis on its nutritional and health benefits

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