Improved ocular absorption kinetics of timolol maleate loaded into a bioadhesive niosomal delivery system

Kaur, Indu Pal; Aggarwal, Deepika; Singh, Harinder; Kakkar, Shilpa

doi:10.1007/s00417-010-1383-0

Cited by 72 publications

(23 citation statements)

References 25 publications

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“…The timolol niosomes achieved a significantly higher (1.7 times) timolol concentration in the aqueous humor than that of the drug solution. This was attributed to better improvement of corneal penetration and prolonged precorneal residence time compared with the timolol aqueous solution (Kaur et al, 2010). Niosomes should have certain attributes in relation to their potential use as vehicles for ocular drug delivery.…”

Section: Ophthalmic Deliverymentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

2013

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Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such serve as versatile drug delivery devices of numerous applications. Additionally, niosomes can be considered as more economically, chemically, and occasionally physically stable alternatives to liposomes. Niosomes can be fabricated using simple methods of preparations and from widely used surfactants in pharmaceutical technology. Many reports have discussed niosomes in terms of physicochemical properties and their applications as drug delivery systems. In this report, a brief and simplified summary of different theories of self-assembly will be given. Furthermore manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes (discomes, proniosomes, elastic and polyhedral niosomes), their recent applications as drug delivery systems, limitations and directions for future research will be discussed.

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Section: Ophthalmic Deliverymentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

2013

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“…Although the vesicular formulations did not show as high an IOP‐lowering activity as that of the marketed formulation of pure drug solution, they extended the duration of activity six to eightfold compared to the marketed formulation. Niosomes coated with the mucoadhesive material chitosan, were developed by Kaur et al to investigate its potential as a drug delivery system for timolol maleate (TM), which also lowers IOP in the treatment of glaucoma 81. The chitosan‐coated niosome showed higher and prolonged corneal permeation of TM into the aqueous humor compared to the pure drug solution.…”

Section: Recent Developments Of Nanomaterials In Ophthalmic Formulmentioning

confidence: 99%

Nanomaterials for Ocular Drug Delivery

Liu

Jones

2012

Macromolecular Bioscience

168

125

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Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause adverse effects in the eye. Recently, an increasing number of scientists have turned to nanomaterial-based drug delivery systems to address the challenges faced by conventional methods. This paper highlights recent applications of various nanomaterials, such as polymeric micelles, hydrogels, liposomes, niosomes, dendrimers, and cyclodextrins as ocular drug delivery systems to enhance the bioavailability of ocular therapeutic agents.

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“…Furthermore the Cmax in the aqueous humor was two-folds increased and a significant broadening of peak from 80 to 120 min was also observed. In a similar study, these authors evaluated the use of niosomes coated with bioadhesive polymer such as Carbopol ® and chitosan to increase the bioavailability of timolol maleate and compared them to timolol solution (0.25%) [41,281]. Authors observed that both coatings increased the antihypertensive effect of the drug.…”

Section: Liposomes For Intraocular Administrationmentioning

confidence: 99%

Nano and microtechnologies for ophthalmic administration, an overview

Herrero–Vanrell

Torre

Andrés‐Guerrero

et al. 2013

Journal of Drug Delivery Science and Technology

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Ocular drug delivery is one of the most challenging fields of pharmaceutical research. They are generally employed to overcome the static (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers) and dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution) of the eye. Ophthalmic formulations must be sterile, and the biomaterials used in the preparation of pharmaceutical systems completely compatible and extremely well tolerated by ocular tissues. The location of the target tissue in the eye will determine the route of administration. Ophthalmic administration systems are intended for topical, intraocular and periocular administration. In this review we describe the main pharmaceutical nano-and microsystems currently under study to administrate drugs in the eye, covering microparticles, nanoparticles, liposomes, microemulsions, niosomes and dendrimers. We have performed the corresponding revision of the published scientific literature always emphasizing the technological aspects. The review discusses also the biomaterials used in the preparation of the nano and microsystems of ophthalmic drug delivery, fabrication techniques, therapeutic significances, and future possibilities in the field.

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Improved ocular absorption kinetics of timolol maleate loaded into a bioadhesive niosomal delivery system

Abstract: This study confirms a sustained and controlled effect of the developed formulation.

Cited by 72 publications

References 25 publications

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

Nanomaterials for Ocular Drug Delivery

Nano and microtechnologies for ophthalmic administration, an overview

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