Improved Overall and Cause-Specific Survival for Melanoma Brain Metastasis Patients Treated with Stereotactic Radiosurgery and Immunotherapy

Intracranial radiotherapy with or without immune checkpoint inhibition for brain metastases: a systematic review and meta-analysis

“…BM, brain metastases; DBF, distant brain failure; ICI, immune checkpoint inhibition; LBF, local brain failure; N, number; RN, radiation necrosis. Summary of main baseline characteristics and efficacy outcomes RT From RT 9.9 vs. 3.29 0.23 (0.05-0.99) vs. 9.8 0.31 (0.16-0.59) RT From RT 18.3 vs. 5.3 0.43 (0.24-0.78) defined from the date of diagnosis of BMs (n=5)(17)(18)(19)(20)(21) or the date of intracranial RT (n=15 studies)(12,18,(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). As statistical heterogeneity among the study outcomes was not high (I 2 =0%; I 2 =29%, respectively), the FE model was applied.…”