Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction

Muhoza, Bertrand; Zhang, Yating; Xia, Shuqin; Cai, Jing; Zhang, Xiaoming; Su, Jiakun

doi:10.1016/j.jff.2018.03.035

Cited by 53 publications

(16 citation statements)

References 36 publications

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“…The XRD patterns of free lutein, PVA/SA nanofibers, and lutein-loaded PVA/SA nanofibers are shown in Figure 1d. Free lutein exhibited two strong crystal diffraction peaks between 10° and 25° (2 θ = 20.54° and 14.06°), which were attributed to the crystallinity of lutein and consistent with the literature [40,41]. As shown in Figure 1d, the crystallization peaks were not observed in the XRD pattern of PVA/SA nanofibers, which might be due to the sensitivity of the measurement being too low to detect the crystalline drug.…”

Section: Resultssupporting

confidence: 87%

Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

et al. 2019

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This investigation aims to study the characteristics and release properties of lutein-loaded polyvinyl alcohol/sodium alginate (PVA/SA) nanofibers prepared by electrospinning. In order to increase PVA/SA nanofibers’ water-resistant ability for potential biomedical applications, the electrospun PVA/SA nanofibers were cross-linked with a mixture of glutaraldehyde and saturated boric acid solution at room temperature. The nanofibers were characterized using scanning electron microscopy (SEM) and X-ray diffractometer (XRD). Disintegration time and contact angle measurements testified the hydrophilicity change of the nanofibers before and after cross-linking. The lutein release from the nanofibers after cross-linking was measured by an ultraviolet absorption spectrophotometer, which showed sustained release up to 48 h and followed anomalous (non-Fickian) release mechanism as indicated by diffusion exponent value obtained from the Korsmeyer–Peppas equation. The results indicated that the prepared lutein-loaded PVA/SA nanofibers have great potential as a controlled release system.

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Section: Resultssupporting

confidence: 87%

Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

et al. 2019

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“…The higher bioaccessibility of encapsulated 7,8-DHF may be due to the following points. First, the amorphous form of 7,8-DHF is known to have a higher bioaccessibility and solubility than its crystalline form ( 53 ). Second, the partial digestion of glycosylated LF may lead to water-soluble peptides generation that can solubilize and bind to 7,8-DHF.…”

Section: Resultsmentioning

confidence: 99%

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

et al. 2022

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In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles and encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three zein/glycosylated LF nanoparticles (79.27–87.24 nm) with low turbidity (<0.220) and polydispersity index (PDI) (<0.230) were successfully established by hydrophobic interactions and hydrogen bonding. Compared with zein/LF nanoparticles, zein/glycosylated LF nanoparticles further increased stability to ionic strength (0–500 mM NaCl) at low pH conditions. Zein/glycosylated LF nanoparticles had nanoscale spherical shape and glycosylated LF changed surface morphology of zein nanoparticles. Besides, encapsulated 7,8-DHF exhibited an amorphous state inside zein/glycosylated LF nanoparticles. Most importantly, zein/glycosylated LF nanoparticles had good water redispersibility, high encapsulation efficiency (above 98.50%), favorable storage stability, and bioaccessibility for 7,8-DHF, particularly LF 40K. Collectively, the above research provides a theoretical reference for the application of zein-based delivery systems.

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“…This phenomenon aligns with the trends observed by Muhoza et al . (2018). The decrease in ζ‐potential could be attributed to the screening effect caused by KGM, which increased the distance between surface charges and the aqueous continuous phase.…”

Section: Resultsmentioning

confidence: 99%

Improved stability and transshipment of enzymatic hydrolysate with ACE inhibitory activity‐loaded nanogels based on glycosylated soybean protein isolate via the Maillard reaction

Cui

Jia

Shi

et al. 2021

Int J of Food Sci Tech

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Summary In this study, soybean protein isolate (SPI)‐konjac glucomannan (KGM) conjugates were fabricated via the Maillard reaction and their potential to improve enzymatic hydrolysate with ACE inhibitory activity stability was assessed. Briefly, we loaded the enzymatic hydrolysate into SPI‐KGM conjugates using a pH‐driven method. Thereafter, the transport pathway of enzymatic hydrolysate with angiotensin‐converting enzyme (ACE) inhibitory activity SPI‐KGM (ACE‐SPI‐KGM) core–shell nanogels was investigated using CaCo‐2 cell monolayer. The results of microstructure, encapsulation efficiency, ACE inhibition ratio and IC50 value verified that the nanogels displayed a spherical structure and excellent physicochemical properties. The ζ‐potential, Z‐average diameter and polydispersity index demonstrated that the stability of the core–shell nanogels was significantly superior to that of the enzymatic hydrolysate. In addition, the transport of the enzymatic hydrolysate in nanogels onto the CaCo‐2 cell monolayer revealed a higher transport capacity and was dominated by cell bypass transport. In summary, the SPI‐KGM conjugates could serve as potential as delivery systems for enzymatic hydrolysate with ACE inhibitory activity to fortify functional foods and medicines.

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Improved stability and controlled release of lutein-loaded micelles based on glycosylated casein via Maillard reaction

Cited by 53 publications

References 36 publications

Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

Preparation of Lutein-Loaded PVA/Sodium Alginate Nanofibers and Investigation of Its Release Behavior

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone

Improved stability and transshipment of enzymatic hydrolysate with ACE inhibitory activity‐loaded nanogels based on glycosylated soybean protein isolate via the Maillard reaction

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