Improved Synergetic Therapy Efficiency of Cryoablation and Nanoparticles for MCF-7 Breast Cancer

Yin, Haitao; Gu, Xuelian; Ye, Yuanyuan; Zhao, Qi; Chang, Zhaohua; Han, Baohui; Chen, Xiaoxiang; Liu, Peifeng

doi:10.2217/nnm-2018-0168

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…PLA has captured remarkable attention owing to its biodegradability, flexibility, and thermoplasticity, all vital for the fabrication of functional PLA-based patches. [77] Furthermore, studies reveal that PLA membranes can efficiently lower the adhesion between the caecum and the AW. [48,78] For instance, the use of PLA films (Surgi Wrap) reduced the incidence of severe adhesion in mice from 71.4% to 10.5%.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

A Review of Advanced Abdominal Wall Hernia Patch Materials

Liang,

Ding,

et al. 2023

Adv Healthcare Materials

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Tension‐free abdominal wall hernia patch materials (AWHPMs) play an important role in the repair of abdominal wall defects (AWDs), which have a recurrence rate of <1%. Nevertheless, there are still significant challenges in the development of tailored, biomimetic, and extracellular matrix (ECM)‐like AWHPMs that satisfy the clinical demands of abdominal wall repair (AWR) while effectively handling post‐operative complications associated with abdominal hernias, such as intra‐abdominal visceral adhesion and abnormal healing. This extensive review presents a comprehensive guide to the high‐end fabrication and the precise selection of these advanced AWHPMs. The review begins by briefly introducing the structures, sources, and properties of AWHPMs, and critically evaluates the advantages and disadvantages of different types of AWHPMs for AWR applications. The review subsequently summarizes and elaborates upon state‐of‐the‐art AWHPM fabrication methods and their key characteristics (e.g., mechanical, physicochemical, and biological properties in vitro/vivo). This review uses compelling examples to demonstrate that advanced AWHPMs with multiple functionalities (e.g., anti‐deformation, anti‐inflammation, anti‐adhesion, pro‐healing properties, etc.) can meet the fundamental clinical demands required to successfully repair AWDs. In particular, there have been several developments in the enhancement of biomimetic AWHPMs with multiple properties, and additional breakthroughs are expected in the near future.

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Section: Biodegradable Polymersmentioning

confidence: 99%

A Review of Advanced Abdominal Wall Hernia Patch Materials

Liang,

Ding,

et al. 2023

Adv Healthcare Materials

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“…Another type of polymeric nanoparticle, mPEG-poly(lactic-co-glycolic acid)-poly-L-lysine (mPEG-PLGA-PLL), can be loaded with doxorubicin and conjugated with cyclic RGD, a cell penetrating peptide that is also selective to tumor cells. mPEG-PLGA-PLL-cRGD nanoparticles have achieved selective targeting of tumor cells and improved survival of tumor-bearing mice 223 . Wang et al synthesized thermally responsive nanoparticles that triggered irinotecan (CPT) when subjected to cold temperatures 224 .…”

Section: Nanomaterials In Cryoablation: a New Opportunitymentioning

confidence: 99%

Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation

Kwak¹,

B²,

Lewandowski³

et al. 2022

Theranostics

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With rapid advances in modern imaging, minimally invasive ablative procedures have emerged as popular alternatives to surgical removal of tumors. Tumor ablation modalities currently offered in clinical practice include microwave ablation, radiofrequency ablation, cryoablation, high-intensity focused ultrasound, and irreversible electroporation. Cryoablation, a non-heat-based method of ablation, is increasingly being used for treating various solid tumors. Accumulated comparative data of cryoablation versus heat-based ablation techniques (e.g., radiofrequency and microwave ablation) shows superior tumor response and quicker recovery time. Evolving research has demonstrated that nanocarriers may serves as excellent catalysts for the cryoablation therapy, imaging guidance, and the co-delivery of therapeutics for minimally invasive, precise, and complete treatment of cancer with immune modulation. This review article focuses on the current status of cryoablation in clinical practice, considers opportunities for enhancing therapeutic outcomes from cryoablation, and discusses new research in the field, including theranostic nanoparticles-mediated cryotherapy and combinational cryo-based immunotherapies.

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“…The clinical benefits of a combination of tumor cryoablation with natural killer cells therapy and Herceptin were studied from Liang et al In 48 patients with HER2- overexpressing recurrent breast cancer, the three-therapy combination treatment resulted in reduced levels of circulating tumor cells, reduced tumor markers such as CEA and CA15-3, and signiﬁcant prolongation of progression free survival 48. The synergetic effect of cryoablation and doxorubicin nanoparticles was assessed as effective in MCF-7 model, a widely studied epithelial cancer cell line derived from breast adenocarcinoma 49…”

Section: Immunologic Effects Of Cryoablationmentioning

confidence: 99%

<p>Cryoablation In The Management Of Breast Cancer: Evidence To Date</p>

Pusceddu¹,

Paliogiannis

Nigri

et al. 2019

BCTT

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Cryoablation has been successfully used to treat various type of solid tumors, including breast carcinomas. This ablation method has the advantage of being a minimally invasive procedure useful in various clinical situations, including early breast cancer and metastatic breast cancer, when co-morbidities preclude the use of surgical treatment. However, due to the small sample size of the available studies, reliable and definitive conclusions on the usefulness of cryoablation in patients with breast cancer could not be drawn. In fact, many aspects necessitate to be elucidated, regarding technical issues, indications, efficacy, imaging follow-up, and possible advantages over other percutaneous ablative methods. This review article has the aim to clarify the current evidence supporting cryoablation of breast cancer, and discuss the future perspectives, including those arising from the new studies on immunological effects related to cryoablation.

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Improved Synergetic Therapy Efficiency of Cryoablation and Nanoparticles for MCF-7 Breast Cancer

Abstract: The synergetic therapy of cryoablation and DOX nanoparticles is an effective therapy means for breast cancer. This strategy provides new means for treating breast cancer.

Cited by 6 publications

References 29 publications

A Review of Advanced Abdominal Wall Hernia Patch Materials

A Review of Advanced Abdominal Wall Hernia Patch Materials

Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation

<p>Cryoablation In The Management Of Breast Cancer: Evidence To Date</p>

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