Improvement in Conduction Velocity after Optic Neuritis Measured with the Multifocal VEP

Yang, E.B.; Hood, Donald C.; Rodarte, C.; Zhang, Xian; Odel, Jeffrey G.; Behrens, Myles M.

doi:10.1167/iovs.06-0475

Cited by 40 publications

(36 citation statements)

References 25 publications

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“…The monocular probability plot for latency was estimated with cross-correlation function in MAT-LAB [29,30] and comparison with the normative database. The monocular latency probability plots were also color coded with saturated color circle and desaturated color circle for deviation from control with P value \ 0.01 and P value \ 0.05, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

et al. 2010

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To investigate the effect of pituitary adenoma compressing the optic chiasm on multifocal visual evoked potential (mfVEP) responses and to compare these responses with visual field defects seen on static automated perimetry (SAP). Eight eyes of four subjects (median age, 41.50 years; interquartile range, 33-51 years) who were diagnosed with pituitary adenoma on magnetic resonance imaging (MRI) and seen to have a bitemporal visual field defect on standard automated perimetry (SAP), and twelve age-matched normal subjects (median age, 47.00 years; interquartile range, 34.75-51.75 years) were subjected to multifocal visual evoked potential (mfVEP) testing. The monocular latencies and monocular amplitudes of each sector of cases were compared with the responses of normative database. The topography of the mfVEP response was compared with corresponding field defect as seen in total deviation threshold on SAP to allow a comparison with conventional subjective perimetry. The mfVEP amplitudes were reduced in the areas with visual field defect on SAP. In 6 out of 8 eyes, locations with preserved amplitudes and no visual defects showed prolonged latency. A prolonged median latency of 9.17 ms (interquartile range, 3.44-17.69 ms) in cases was seen when compared to the median latency of 1.67 ms (interquartile range, 0.94-4.17 ms) in age-matched controls with P value of 0.054. Chiasmal compression due to pituitary adenoma causes the reduction of amplitudes and prolongation of latencies of the mfVEP response. The mfVEP can be used to assess objectively the topography of the visual field in compressive optic neuropathy secondary to pituitary adenomas. It can be used in assessing the subjects whose visual field report is unreliable and prolonged median latency can be an early sign of the disease.

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Section: Discussionmentioning

confidence: 99%

“…The monocular latency probability plots were also color coded with saturated color circle and desaturated color circle for deviation from control with P value \ 0.01 and P value \ 0.05, respectively. Blue and red color was used for right eye and left eye, respectively [29,30]. The black circle indicates no significant difference.…”

Section: Discussionmentioning

confidence: 99%

Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

et al. 2010

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“…Electrophysiological evidence of demyelinization may improve, worsen or remain the same (e.g. [2,3]). Thus, without electrophysiological testing a diagnosis of non-acute ON rests on an expensive MRI test.…”

Section: Introductionmentioning

confidence: 99%

A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis

et al. 2008

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Purpose-To compare conventional visual evoked potential (cVEP) and multifocal visual evoked potential (mfVEP) methods in patients with optic neuritis/multiple sclerosis (ON/MS).Methods-mfVEPs and cVEPs were obtained from eyes of the 19 patients with multiple sclerosis confirmed on MRI scans, and from eyes of 40 normal controls. For the mfVEP, the display was a pattern-reversal dartboard array, 48° in diameter, which contained 60 sectors. Monocular cVEPs were obtained using a checkerboard stimulus with check sizes of 15′ and 60′. For the cVEP, the latency of P100 for both check sizes were measured, while for the mfVEP, the mean latency, percent of locations with abnormal latency, and clusters of contiguous abnormal locations were obtained.Results-For a specificity of 95%, the mfVEP(interocular cluster criterion) showed the highest sensitivity (89.5%) of the 5 monocular or interocular tests. Similarly, when a combined monocular/ © Springer-Verlag 2008Correspondence to: Donald C. Hood, dch3@columbia.edu. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript interocular criterion was employed, the mfVEP(cluster criterion) had the highest sensitivity (94.7%)/ specificity (90%), missing only one patient. The combined monocular/interocular cVEP(60′) test had a sensitivity (84.2%)/specificity (90%), missing 3 patients, 2 more than did the monocular/interocular mfVEP(cluster) test. NIH Public AccessConclusion-As the cVEP is more readily available and currently a shorter test, it should be used to screen patients for ON/MS with mfVEP testing added when the cVEP test is negative and the damage is local.

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“…After the recording, additional mfVEP responses were calculated by subtraction (with channels 1, 2, and 3 corresponding to the mfVEP results derived from the left, middle, and right recording electrodes): Oblique channel 4 = channel 1 -channel 2; oblique channel 5 = channel 1 -channel 3; and horizontal channel 6 = channel 2 -channel 3. We used this method as a reference because it is established and well described in the literature [6][7][8][9][10]. Written consent was obtained from all participants.…”

Section: Methodsmentioning

confidence: 99%

Improving the quality of multifocal visual evoked potential results by calculating multiple virtual channels

et al. 2011

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Improvement in Conduction Velocity after Optic Neuritis Measured with the Multifocal VEP

Abstract: A substantial percentage of ON/MS patients show a long-term improvement in conduction velocity. Because this improvement can be local, the mfVEP should allow these improvements to be monitored in patients with ON/MS.

Cited by 40 publications

References 25 publications

Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma

A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis

Improving the quality of multifocal visual evoked potential results by calculating multiple virtual channels

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